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UL49

Gene
UL49
Protein
Uncharacterized protein UL49
Organism
Human cytomegalovirus (strain AD169)
Length
570 amino acids
Similarity
Belongs to the herpesviridae UL49 family.
Mass
63.851 kDa
Sequence
MASRRLRHAPHTATDEFHQALRRLFAPLCVHEDHFHVQLVIGRGALQPEEAAVETSQPPAQFAAQTSAVLQQQLVHHVPRSCVLHLFVTDKRFLNRELGDRLYQRFLREWLVCRQAEREAVTALFQRMVMTKPYFVFLAYVYSMDCLHTVAVRTMAFLRFERYDTDYLLRRLRLYPPERLHALLDGVTASLLGDLHRFLFGVDLRLPVLHPTSSPCLALLRAKRFDARADLAVYHRNQWCHQRQPRSPQLRGLIAALRRYAGKVPCGNPLYVLARQAVQTFCDTCPRYLVPLRALGLHDETRGGGSTAAAAAVGHAGAGQQARHVEPTKIVLFALSAALRGGLIGSVIDLPLWCLCRLKCERHLDARSLVAVVCRQCGHCLNLGKEKLHCQQNFPLNSMFYYRDRQEKSVIFNTHAELVHCSLCGSQRVVRQRVYELVSETLFGQRCVRVGWKAVLGLNAACAVYDHRLAFDVILPCAARTCDSTVVVRDVTVPRLLRLTSHGHGLLCARCQTGEYRDSCLESEDGAPLCRGCALVKQTACHVGGHIVQQARGGLAAASSSSSPHGLPHV

Gene
UL49
Protein
Protein UL49
Organism
Human cytomegalovirus (strain Merlin)
Length
570 amino acids
Similarity
Belongs to the herpesviridae UL49 family.
Mass
63.833 kDa
Sequence
MANRRLRHAPHTATDEFHQALRRLFAPLCVHEDHFHVQLVIGRGALQPEEAAVETSQPPAQFAAQTSAVLQQQLVHHVPRSCVLHLFVTDKRFLNRELGDRLYQRFLREWLVCRQAEREAVTALFQRMVMTKPYFVFLAYVYSMDCLHTVAVRTMAFLRFERYDTDYLLRRLRLYPPERLHALLDGVTVSLLGDLHRFLFGVDLRLPVLHPTSSPCLALLRAKRFDARADLAVYHRNQWCHQRQPRSPQLRGLIAALRRHAGKVPCGNPLYVLARQAVQTFCDTCPRYLVPLRALGLHDETRGGGSTAAAAAVGHAGAGQQAHHVEPTKIVLFALSAALRGGLIGSVIDLPLWCLCRLKCERHLDARSLVAVVCRQCGHCLNLGKEKLHCQQNFPLNSMFYYRDRQEKSVIFNTHAELVHCSLCGSQRVVRQRVYELVSETLFGQRCVRVGWKAVLGLNAACAVYDHRLAFDVILPCAARTCDSTVVVRGVTVPRLLRLTSHGHGLLCARCQTGEYRDSCLESEDGAPLCRGCALVKQTACHVGGHIVQQARGGLAATSSSSSPHGLPHV

Gene
UL49
Protein
Tegument protein VP22
Organism
Human herpesvirus 1 (strain 17)
Length
301 amino acids
Function
Tegument protein that plays different roles during the time course of infection. Participates in both the accumulation of viral mRNAs and viral protein translation at late time of infection. Modulates the RNase activity of the virion host shutoff protein UL41 probably to ensure necessary levels of key cellular mRNAs and proteins. Plays a role in microtubule reorganization that occurs after viral infection by stabilizing microtubule network. Finally, may prevent nucleosomal deposition onto the viral genome by interacting with and inhibiting host SET.
Similarity
Belongs to the alphaherpesvirinae VP22 tegument protein family.
Mass
32.254 kDa
Sequence
MTSRRSVKSGPREVPRDEYEDLYYTPSSGMASPDSPPDTSRRGALQTRSRQRGEVRFVQYDESDYALYGGSSSEDDEHPEVPRTRRPVSGAVLSGPGPARAPPPPAGSGGAGRTPTTAPRAPRTQRVATKAPAAPAAETTRGRKSAQPESAALPDAPASTAPTRSKTPAQGLARKLHFSTAPPNPDAPWTPRVAGFNKRVFCAAVGRLAAMHARMAAVQLWDMSRPRTDEDLNELLGITTIRVTVCEGKNLLQRANELVNPDVVQDVDAATATRGRSAASRPTERPRAPARSASRPRRPVE

Gene
UL49
Protein
Tegument protein VP22
Organism
Human herpesvirus 2 (strain HG52)
Length
300 amino acids
Function
Tegument protein that plays different roles during the time course of infection. Participates in both the accumulation of viral mRNAs and viral protein translation at late time of infection. Modulates the RNase activity of the virion host shutoff protein UL41 probably to ensure necessary levels of key cellular mRNAs and proteins. Plays a role in microtubule reorganization that occurs after viral infection by stabilizing microtubule network.
Similarity
Belongs to the alphaherpesvirinae VP22 tegument protein family.
Mass
31.791 kDa
Sequence
MTSRRSVKSCPREAPRGTHEELYYGPVSPADPESPRDDFRRGAGPMRARPRGEVRFLHYDEAGYALYRDSSSDDDESRDTARPRRSASVAGSHGPGPARAPPPPGGPVGAGGRSHAPPARTPKMTRGAPKASATPATDPARGRRPAQADSAVLLDAPAPTASGRTKTPAQGLAKKLHFSTAPPSPTAPWTPRVAGFNKRVFCAAVGRLAATHARLAAVQLWDMSRPHTDEDLNELLDLTTIRVTVCEGKNLLQRANELVNPDAAQDVDATAAARGRPAGRAAATARAPARSASRPRRPLE

Gene
UL49
Protein
Tegument protein VP22
Organism
Psittacid herpesvirus 1 (isolate Amazon parrot/-/97-0001/1997)
Length
284 amino acids
Function
Tegument protein that plays different roles during the time course of infection. Participates in both the accumulation of viral mRNAs and viral protein translation at late time of infection. Modulates the RNase activity of the virion host shutoff protein UL41 probably to ensure necessary levels of key cellular mRNAs and proteins. Plays a role in microtubule reorganization that occurs after viral infection by stabilizing microtubule network.
Similarity
Belongs to the alphaherpesvirinae VP22 tegument protein family.
Mass
31.208 kDa
Sequence
MSYYTNEQSGGEKKTRKSSSSKRSDRKDSASSSPPPPGAVRGRVMYPPGYDGDAWLSRRERRESSGSSDSSSSSRDDDDRRQPEQQPKAQSTRERRKSQTTVTTRRKTDRGDGGKSSNSNGPWSIDNQCANLVKRLSLAKGFGPSATPASDSDRWRTTTNPANRSAFVQAVSVTAMAQGELAARAAWEKYKPRNNEDLEKLVETLEIKITVNPGRGLWDVASNIASAIRNGQPITHDLLYASSPAGDGARTSRRQSCRSKSMPRGDEEDERDAGSPRPPSSRRR

Gene
UL49
Protein
Tegument protein VP22
Organism
Bovine herpesvirus 1.1 (strain Cooper)
Length
258 amino acids
Function
Tegument protein that plays different roles during the time course of infection. Participates in both the accumulation of viral mRNAs and viral protein translation at late time of infection. Modulates the RNase activity of the virion host shutoff protein UL41 probably to ensure necessary levels of key cellular mRNAs and proteins. Plays a role in microtubule reorganization that occurs after viral infection by stabilizing microtubule network.
Similarity
Belongs to the alphaherpesvirinae VP22 tegument protein family.
Mass
26.865 kDa
Sequence
MARFHRPSEDEDDYEYSDLWVRENSLYDYESGSDDHVYEELRAATSGPEPSGRRASVRACASAAAVQPAARGRDRAAAAGTTVAAPAAAPARRSSSRASSRPPRAAADPPVLRPATRGSSGGAGAVAVGPPRPRAPPGANAVASGRPLAFSAAPKTPKAPWCGPTHAYNRTIFCEAVALVAAEYARQAAASVWDSDPPKSNERLDRMLKSAAIRILVCEGSGLLAAANDILAARAQRPAARGSTSGGESRLRGERARP