Function
UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme has glucuronidating capacity with androgens, such as testosterone, dihydrotestosterone (DHT) and 3-alpha-diol. It is also active on catecholoestrogens including 1,3,5,10-oestratriene-3,4-diol-17-one.
Sequence
MSLKWTSVFLLLQLSCYFSSGSCGKVLVWPTEYSHWINMKTILEELVRRRHEVTVLTSSASTFVNDSKSSAIKFEVYPTSLTKNDMEDSLMKLLDIWTYSISNSTFLSYFSKLQELCWEYYYYSEKLCKDAVLNKKLMTKLKETKFDVILADALNPCGELLAELFNIPFVYSLRFTVGYTFEKNGGGFLFPPSYVPVVMSELSDQMTFTERIKNMIHKLYFDFWFQIHDIKKWDQFYSEVLGRPTTLFETMRKAEMWLIRTYWDFEFPRPFLPNVDFVGGLHCKPAKPLPKEMEEFVQSSGENGVVVFSLGSMISNMSEERANMIASALAQIPQKVLWKFDGKKPNTLGSNTRLYKWLPQNDLLGHPKTKAFITHGGTNGIYEAIYHGIPMVGIPLFADQHDNIVHMKVKGAALSVDIRTMSSRDLLNALKSVINEPIYKENAMKLSRIHHDQPMKPLDRAVFWIEFVMRHKGAKHLRVAAHNLTWIQYHSLDVIAFLLACVAAVIFIITKCCLFCFRKLAKTGKKKKWD