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UCN

Gene
UCN
Protein
Urocortin
Organism
Homo sapiens
Length
124 amino acids
Function
Acts in vitro to stimulate the secretion of adrenocorticotropic hormone (ACTH) (PubMed:8612563). Binds with high affinity to CRF receptor types 1, 2-alpha, and 2-beta (PubMed:8612563). Plays a role in the establishment of normal hearing thresholds (By similarity). Reduces food intake and regulates ghrelin levels in gastric body and plasma (By similarity).
Similarity
Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.
Mass
13.458 kDa
Sequence
MRQAGRAALLAALLLLVQLCPGSSQRSPEAAGVQDPSLRWSPGARNQGGGARALLLLLAERFPRRAGPGRLGLGTAGERPRRDNPSLSIDLTFHLLRTLLELARTQSQRERAEQNRIIFDSVGK

Gene
Ucn
Protein
Urocortin
Organism
Mus musculus
Length
122 amino acids
Function
Acts in vitro to stimulate the secretion of adrenocorticotropic hormone (ACTH) (By similarity). Binds with high affinity to CRF receptor types 1, 2-alpha, and 2-beta (By similarity). Plays a role in the establishment of normal hearing thresholds (PubMed:12091910). Reduces food intake and regulates ghrelin levels in gastric body and plasma (By similarity).
Similarity
Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.
Mass
13.558 kDa
Sequence
MIQRGRATLLVALLLLAQLRPESSQWSPAAAAATGVQDPNLRWSPGVRNQGGGVRALLLLLAERFPRRAGSEPAGERQRRDDPPLSIDLTFHLLRTLLELARTQSQRERAEQNRIIFDSVGK

Gene
Ucn
Protein
Urocortin
Organism
Rattus norvegicus
Length
122 amino acids
Function
Acts in vitro to stimulate the secretion of adrenocorticotropic hormone (ACTH) (PubMed:7477349). Binds with high affinity to CRF receptor types 1, 2-alpha, and 2-beta (By similarity). Plays a role in the establishment of normal hearing thresholds (By similarity). Reduces food intake and regulates ghrelin levels in gastric body and plasma (PubMed:21540451).
Similarity
Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.
Mass
13.711 kDa
Sequence
MRQRGRATLLVALLLLVQLRPESSQWSPAAAAANVVQDPNLRWNPGVRNQGGGVRALLLLLAERFPRRAGSEPAGERQRRDDPPLSIDLTFHLLRTLLELARTQSQRERAEQNRIIFDSVGK