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UCH2

Gene
uch2
Protein
Ubiquitin carboxyl-terminal hydrolase isozyme L5
Organism
Dictyostelium discoideum
Length
343 amino acids
Function
Protease that specifically cleaves 'Lys-48'-linked polyubiquitin chains. Deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome (By similarity).
Similarity
Belongs to the peptidase C12 family.
Mass
39.325 kDa
Sequence
MSENEGWCTIESDPGVFTELITKIGVKDIQVEELYTLDSSEYDRLKPVLGLIFLFKWEKEEENRTISDNENIFFANQVIQNACATQAILSVLLNSEGIELGEELSNFKSFVGDFPPMMKGEAIGNSELIKETHNSFTVQDPFIFSKKKNRKPSDAFHFISFIPFQGKVYELDGLKKGPYCLGDCTPDNWLEIATPFIQKRMEKYSQGEIRFNLMAVIKNRQTTLQEKILTLEKKKNDLEIKLSELNSGSGGDNKEESGGATPTTKEDLNFMINVVNNDIEEANNEILMEQEKFRNWKDENIRRKHNFTPLILNLIKGLAEKDNLQPLIQKAKDQISQKQQQHK

Gene
UCH2
Protein
Ubiquitin carboxyl-terminal hydrolase 2
Organism
Arabidopsis thaliana
Length
330 amino acids
Function
Ubiquitin-protein hydrolase involved in the release of ubiquitin attached via both peptide and isopeptide linkages. Able to cleave 'Lys-48'-linked polyubiquitin chains. Involved in the direct or indirect regulation of AUX/IAA proteins stability (PubMed:17559514). Acts as a linker between the TREX-2 complex and 26S proteasome (PubMed:22951400).
Similarity
Belongs to the peptidase C12 family.
Mass
37.499 kDa
Sequence
MSWCTIESDPGVFTELIQQMQVKGVQVEELYSLDSDSLNNLRPVYGLIFLFKWQAGEKDERPTIQDQVSNLFFANQVINNACATQAILAILLNSPEVDIGPELSALKEFTKNFPSDLKGLAINNSDSIRAAHNSFARPEPFVPEEQKAATKDDDVYHFISYIPVDGVLYELDGLKEGPISLGPCPGDQTGIEWLQMVQPVIQERIERYSQSEIRFNLLAVIKNRKDIYTAELKELQRQREQLLQQANTCVDKSEAEAVNALIAEVGSGIEAASDKIVMEEEKFMKWRTENIRRKHNYIPFLFNFLKLLAEKKQLKPLIEKAKKQKTESST

Gene
uch2
Protein
Ubiquitin carboxyl-terminal hydrolase 2
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Length
300 amino acids
Function
Ubiquitin-protein hydrolase is involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin.
Similarity
Belongs to the peptidase C12 family.
Mass
34.196 kDa
Sequence
MSWTTIESDAGVFTDLIENLGVKDVEVDELYSLDVDSLRQFPDIYGIIFLFKWNSKVDKPDGTMDYDSMDNIFFAKQVINNACATQALLSVLLNHSDEIDLGTTLSEFKDFSKTLPPELKGEALGNSEHIRCCHNSFARSDPFISEEVRAATDEDEVYHFIAYTNINNVFYELDGLQAAPINHGSCTKEEFAEKAVSVIQARIANYDPAEIRFNLMVICKDKKASLLTREDLTDEEKAASIAVEDEKRLRWKRENQLRRHNFVGLFVELSKLLVKDRIDKNTWNSTLETAKAKYASQKRP