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UBXN2B

Gene
UBXN2B
Protein
UBX domain-containing protein 2B
Organism
Gallus gallus
Length
365 amino acids
Function
Adapter protein required for Golgi and endoplasmic reticulum biogenesis. Involved in Golgi and endoplasmic reticulum maintenance during interphase and in their reassembly at the end of mitosis. Regulates the centrosomal levels of kinase AURKA/Aurora A during mitotic progression by promoting AURKA removal from centrosomes in prophase. Also, regulates spindle orientation during mitosis.
Similarity
Belongs to the NSFL1C family.
Mass
40.844 kDa
Sequence
MADGGASPAQQEGEMSAAGPGLRRERQHRGSGRPPSARDLQLALAELYEDEAKRQSLRSDKPTTTKMSNSKGLKIDSFRSLRKPERSMSDDKENQRFYSGDSEYRGLQIWGASNNPSKIVAELFKEAKEHGAVPLDEASRTSGDFSKAKSFSGGGYRLGDSSQKHSEYIYGENQDVQILLKLWRNGFSLDDGELRSYSDPINAQFLESVKRGEIPVDLQRLVHGGQVNLDMEDHQEQEYVKPRLRFKAFSGEGQKLGSLTPEIVSTPSSPEEEDKSILNAPVLIDDSVPATKIQIRLADGSRLIQRFNQTHRIKDIRDFIIQSRPAFATTDFVLVTTFPNKELTDESLTLREADILNTVILQQLK

Gene
ubxn2b
Protein
UBX domain-containing protein 2B
Organism
Xenopus laevis
Length
350 amino acids
Function
Adapter protein required for Golgi and endoplasmic reticulum biogenesis. Involved in Golgi and endoplasmic reticulum maintenance during interphase and in their reassembly at the end of mitosis. Regulates the centrosomal levels of kinase aurka-a/Aurora A during mitotic progression by promoting aurka-a removal from centrosomes in prophase. Also, regulates spindle orientation during mitosis.
Similarity
Belongs to the NSFL1C family.
Mass
39.549 kDa
Sequence
MEERENSEEGDDGAGEEEEEDQGSGEDGGEVGAEREQEAELKDSLRPSVLDLQLALARLCEDEYQDQPSKMPVLGLQIKDHQFERSFSGNGKVPSPGKIVNELFKEAKEHGAIPIDDTSKSSGAFYRARTFTGRGYKLGDSSKREFEYMQGEDPFEQGQEIQILLKLWSNGFSLDDGELRSYSDPINAEFLESVKKGEIPVELQRLVHGGQVNLDMEDHQDQEYIKPRLKFKAFSGEGKKLGSVTPEIISTPSSPEEEHKRFLNAEVDLDEHVPTTKIQIRLADGTRLIQRFNLSHRIMDVRQFIIHARSDFAQCDFALLTTFPNVELTDETQTLEEADILNTVILQRLK

Gene
UBXN2B
Protein
UBX domain-containing protein 2B
Organism
Homo sapiens
Length
331 amino acids
Function
Adapter protein required for Golgi and endoplasmic reticulum biogenesis (PubMed:17141156). Involved in Golgi and endoplasmic reticulum maintenance during interphase and in their reassembly at the end of mitosis (PubMed:17141156). The complex formed with VCP has membrane fusion activity; membrane fusion activity requires USO1-GOLGA2 tethering and BET1L (PubMed:17141156). VCPIP1 is also required, but not its deubiquitinating activity (PubMed:17141156). Together with NSFL1C/p47, regulates the centrosomal levels of kinase AURKA/Aurora A during mitotic progression by promoting AURKA removal from centrosomes in prophase (PubMed:23649807). Also, regulates spindle orientation during mitosis (PubMed:23649807).
Similarity
Belongs to the NSFL1C family.
Mass
37.077 kDa
Sequence
MAEGGGPEPGEQERRSSGPRPPSARDLQLALAELYEDEVKCKSSKSNRPKATVFKSPRTPPQRFYSSEHEYSGLNIVRPSTGKIVNELFKEAREHGAVPLNEATRASGDDKSKSFTGGGYRLGSSFCKRSEYIYGENQLQDVQILLKLWSNGFSLDDGELRPYNEPTNAQFLESVKRGEIPLELQRLVHGGQVNLDMEDHQDQEYIKPRLRFKAFSGEGQKLGSLTPEIVSTPSSPEEEDKSILNAVVLIDDSVPTTKIQIRLADGSRLIQRFNSTHRILDVRNFIVQSRPEFAALDFILVTSFPNKELTDESLTLLEADILNTVLLQQLK

Gene
Ubxn2b
Protein
UBX domain-containing protein 2B
Organism
Mus musculus
Length
331 amino acids
Function
Adapter protein required for Golgi and endoplasmic reticulum biogenesis. Involved in Golgi and endoplasmic reticulum maintenance during interphase and in their reassembly at the end of mitosis. The complex formed with VCP has membrane fusion activity; membrane fusion activity requires USO1-GOLGA2 tethering and BET1L. VCPIP1 is also required, but not its deubiquitinating activity. Together with NSFL1C/p47, regulates the centrosomal levels of kinase AURKA/Aurora A during mitotic progression by promoting AURKA removal from centrosomes in prophase. Also, regulates spindle orientation during mitosis.
Similarity
Belongs to the NSFL1C family.
Mass
37.444 kDa
Sequence
MAEGGRAEPEEQERGSSRPRPPSARDLQLALAELYEDEMKCKSSKPDRSTPATCRSPRTPPHRLYSGDHKYDGLHIVQPPTGKIVNELFKEAREHGAVPLNEATRSSREDKTKSFTGGGYRLGNSFYKRSEYIYGENQLQDVQVLLKLWRNGFSLDDGELRPYSDPTNAQFLESVKRGETPLELQRLVHGAQVNLDMEDHQDQEYIKPRLRFKAFSGEGQKLGSLTPEIVSTPSSPEEEDKSILNAAVLIDDSMPTTKIQIRLADGSRLVQRFNSTHRILDVRDFIVRSRPEFATTDFILVTSFPSKELTDETVTLQEADILNTVILQQLK

Gene
Ubxn2b
Protein
UBX domain-containing protein 2B
Organism
Rattus norvegicus
Length
331 amino acids
Function
Adapter protein required for Golgi and endoplasmic reticulum biogenesis. Involved in Golgi and endoplasmic reticulum maintenance during interphase and in their reassembly at the end of mitosis. The complex formed with VCP has membrane fusion activity; membrane fusion activity requires USO1-GOLGA2 tethering and BET1L. VCPIP1 is also required, but not its deubiquitinating activity. Together with NSFL1C/p47, regulates the centrosomal levels of kinase AURKA/Aurora A during mitotic progression by promoting AURKA removal from centrosomes in prophase. Also, regulates spindle orientation during mitosis.
Similarity
Belongs to the NSFL1C family.
Mass
37.075 kDa
Sequence
MAEGGGAEPEEQERRSSRPRPPSARDLQLALAELYEDEMKCKSSKPDRSTATAFKSPRTPPLRLYSGDQEYGGLHIAQPPTGKIVNELFKEAREHGAVPLNEATRSSSDDKAKSFTGGGYRLGSSFYKRSEYIYGENQLQDVQILLRLWSNGFSLDDGELRPYSDPTNAQFLESVKRGEIPLELQRLVHGSQVSLDMEDHQDQEYIKPRLRFKAFSGEGQKLGSLTPEIVSTPSSPEEEDKSILNAAVLIDDSVPTTKIQIRLADGSRLIQRFNSTHRILDVRDFIVQSRPEFATTDFILVTSFPSKELTDESVTLQDADILNTVILQQLK