uba5

NEDD8-activating enzyme E1 regulatory subunit

517 amino acids

Regulatory subunit of the dimeric uba3-ula1 E1 enzyme. E1 activates NEDD8/ubl1 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of ubc12 (By similarity).

Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.

59.569 kDa

MGTSAKMQKYDRQVRLWKAEGQNAIEKSHVCLLYANTVGCEALKNLILPGIGSFAVVDDTSVDFSMDGMNFFIQYDQEGKSRARCTASLLQQLNPNVEMEYLEMSPEALIDKNIEYFSKFSVVLSSNLKEKPLFRLEEYLRSHKIPLLHFNSVGFAGILRISTHEYTTTQSQPELPQDLRLKNPWPELINYVKSMDLDNMDSSSLSEIPYIVLIIHVLLKVSPAHAQNSQEADDCAMFRKIMEEYKGKCDSENIEEASSNSWKAFKEYKLPSNVYEVLHDTRCVKIQEDSESFWIMAHCLKMFYDETEFLPLSGLLPDMNCSTQQYVKLQVIYKEKSENDILKFKKYVQQTLKRLNRSVEEITDLEIKHFSRNCLNIKVMDFKTMKEEYQPTSNSVLESSSIDSNSLLPWYLAFRIYDTILEKHGKNYKEAFSDTTKTISVAQSFLSQIGLEKFFDVVYTAIQELERADGHELHSISSFIGGIVAQETIKLLAQQYLPLNNTFVFDGVHSRTETFKL

UBA5

Ubiquitin-like modifier-activating enzyme 5

404 amino acids

E1-like enzyme which activates UFM1 and SUMO2.

Belongs to the ubiquitin-activating E1 family. UBA5 subfamily.

44.697 kDa

MAESVERLQQRVEELERELAQERSRRALGSGDGGGGRARIEKMSSEVVDSNPYSRLMALKRMGIVSDYEKIRTFTVAIVGVGGVGSVTAEMLTRCGIGKLLLFDYDKVELANMNRLFFQPHQAGLSKVQAAEHTLRNINPDVLFEVHNYNITTVENFEHFMNRISNGGLEEGKPVDLVLSCVDNFEARMTINTACNELGQTWMESGVSENAVSGHIQLIIPGESACFACAPPLVVAANIDEKTLKREGVCAASLPTTMGVVAGILVQNVLKFLLNFGTVSFYLGYNAMQDFFPTMSMKPNPQCDDRNCRKQQKEYKKKVAALPKQEVIQEEGEIIHEDNEWGIELVSEISEEELKKSSGPIPDLPEGIIVAYTVPQKQEDSVPEVTVEDSGESLEDLMAKMKNI

Uba5

Ubiquitin-like modifier-activating enzyme 5

404 amino acids

E1-like enzyme which activates UFM1.

Belongs to the ubiquitin-activating E1 family. UBA5 subfamily.

44.167 kDa

MSHAIDELQAIIADLKTELETEPKSSGGVASNSRLARDRIDRMSAEVVDSNPYSRLMALQRMNIVKDYERIRYKAVAIVGVGGVGSVTADMLTRCGIGKLILFDYDKVELANMNRLFFTPDQAGLSKVAAAAATLSFINPDVEIETHNYNITTVENFDRFLDTISQGGRIAGQPVDLVLSCVDNFEARMAINAACNERNLNWFESGVSENAVSGHIQFIRPGDTACFACAPPLVVAENIDEKTLKREGVCAASLPTTMGITAGFLVQNALKYLLNFGEVSDYLGYNALSDFFPKMTLKPNPQCDDRNCLVRQKEFQARPKPVLIEEKAVSEEPLHATNEWGIELVAEDAPESNTTPAETPVMGEGLRLAYEAPEKSSETSEETVSAATADETSLEDLMAQMKSM

UBA5

Ubiquitin-like modifier-activating enzyme 5

404 amino acids

E1-like enzyme which activates UFM1 and SUMO2.

Belongs to the ubiquitin-activating E1 family. UBA5 subfamily.

44.863 kDa

MAESVERLQQRVQELERELAQERSLQVPRSGDGGGGRVRIEKMSSEVVDSNPYSRLMALKRMGIVSDYEKIRTFAVAIVGVGGVGSVTAEMLTRCGIGKLLLFDYDKVELANMNRLFFQPHQAGLSKVQAAEHTLRNINPDVLFEVHNYNITTVENFQHFMDRISNGGLEEGKPVDLVLSCVDNFEARMTINTACNELGQTWMESGVSENAVSGHIQLIIPGESACFACAPPLVVAANIDEKTLKREGVCAASLPTTMGVVAGILVQNVLKFLLNFGTVSFYLGYNAMQDFFPTMSMKPNPQCDDRNCRKQQEEYKKKVAALPKQEVIQEEEEIIHEDNEWGIELVSEVSEEELKNFSGPVPDLPEGITVAYTIPKKQEDSVTELTVEDSGESLEDLMAKMKNM

UBA5

Ubiquitin-like modifier-activating enzyme 5

404 amino acids

E1-like enzyme which activates UFM1 and SUMO2.

Belongs to the ubiquitin-activating E1 family. UBA5 subfamily.

44.774 kDa

MAESVERLQQRVQELERELAQERSLQVPRSGDGGGGRVRIEKMSSEVVDSNPYSRLMALKRMGIVSDYEKIRTFAVAIVGVGGVGSVTAEMLTRCGIGKLLLFDYDKVELANMNRLFFQPHQAGLSKVQAAEHTLRNINPDVLFEVHNYNITTVENFQHFMDRISNGGLEEGKPVDLVLSCVDNFEARMTINTACNELGQTWMESGVSENAVSGHIQLIIPGESACFACAPPLVVAANIDEKSLKREGVCAASLPTTMGVVAGILVQNVLKFLLNFGTVSFYLGYNAMQDFFPTMSMKPNPQCDDRNCRKQQEEYKKKVAALPKQEVIQEKEEIIHEDNEWGIELVSEVSEEELKNSSGPVPDLPEGITVAYTIPKKQEDSVTEVTVEDSGESLEDLMAKMKNM

Uba5

Ubiquitin-like modifier-activating enzyme 5

403 amino acids

E1-like enzyme which activates UFM1 and SUMO2.

Belongs to the ubiquitin-activating E1 family. UBA5 subfamily.

44.79 kDa

MADSVERLRQRVEELEQELARERTRRSGGDGHCGRTRIQEMSDEVLDSNPYSRLMALKRMGIVSDYKKIRTYAVAIVGVGGVGSVTAEMLTRCGIGKLLLFDYDKVELANMNRLFFQPYQAGLSKVHAAEHTLRNINPDVLFEVHNYNITTVEHFEHFMNRISNGGLEEGQPVDLVLSCVDNFEARMAINTACNELGQTWMESGVSENAVSGHIQLMIPGESACFACAPPLVVASNIDEKTLKREGVCAASLPTTMGVVAGILVQNVLKFLLKFGTVSFYLGYNAMQDFFPTMFMKPNPQCDDKNCRKQQEEYKKRAAALPTQEAEPQEEAEVVHEDNEWGIELVSEVSEEELKNSSGPVPTLPEGITVAYTVPKKTEDSASEVTVEDSGESLEDLMARMKNM

Uba5

Ubiquitin-like modifier-activating enzyme 5

403 amino acids

E1-like enzyme which activates UFM1 and SUMO2.

Belongs to the ubiquitin-activating E1 family. UBA5 subfamily.

44.895 kDa

MAESVERLLQRVEELEQELARERSRRIAGDGHCGRTRIQKMSDEVVDSNPYSRLMALKRMGVVSDYEKIRTYAVAIVGVGGVGSVTAEMLTRCGIGKLLLFDYDKVELANMNRLFFQPYQAGMSKVQAAEHTLRSINPDVLFEVHNYNITTVEHFEHFMNRISNGGLEEGQPVDLVLSCVDNFEARMAINTACNELGQTWMESGVSENAVSGHIQLMVPGESACFACAPPLVVASNIDEKTLKREGVCAASLPTTMGVVAGILVQNVLKFLLKFGTVSFYLGYNAMQDFFPTMFMKPNPQCDDKNCRKQQEEYKKRAPAQPTQETAPQEEEEVVHEDNEWGIELVSEVSEEELKNSSGPVPTLPEGITVAYTVPKKREDSVSEVTVEDSGESLEDLMARMKKM

uba5

Ubiquitin-like modifier-activating enzyme 5

399 amino acids

E1-like enzyme which activates UFM1 and SUMO2.

Belongs to the ubiquitin-activating E1 family. UBA5 subfamily.

44.463 kDa

MEKLIEELRSRVSELEEELHRVRNGEQVHEGHRAKINTMSAEVVDSNPYSRLMALKRMGIVEDYEKIRTFTVAVVGVGGVGSVTAEMLTRCGIGKLLLFDYDKVEMANMNRLFFQPHQAGLSKVEAAEHTLRNINPDVQFEVHNYNITTLDNFQHFMDRISKGGLKEGTPVDLVLSCVDNFEARMAINTACNELVQIWMESGVSENAVSGHIQLIKPGETACFACAPPLVVAANIDEKTLKREGVCAASLPTTMGVVAGMLVQNVLKYLLNFGTVSFYLGYNAMQDFFPTMAMKPNPQCGDKYCRKQQEEFKLKEAARPKQEPIVVKEEEIVHEDNDWGIELVSEVSEEELKAASGPVPELPEGIKVAYTVPITEPTSGFIVEDSEQSLDELMAQMKNL

uba5

Ubiquitin-like modifier-activating enzyme 5

398 amino acids

E1-like enzyme which activates ufm1 and sumo2.

44.234 kDa

MATVEELKLRIRELENELIKSKQKQSDAEHNIRPKIEQMSAEVVDSNPYSRLMALKRMGIVQDYEKIRSFAVAVVGVGGVGSVTAEMLTRCGIGKLLLFDYDKVELANMNRLFFQPHQAGLSKVEAAQHTLRNINPDVAFETHNYNITTMDNFTHFMDRVSHGGLEEGKPVDLILSCVDNFEARMAINTACNELGQIWMESGVSENAVSGHIQLIIPGETACFACAPPLVVAANIDEKTLKRDGVCAASLPTTMGVVAGLLVQNVLKYLLGFGTVSYYLGYNAMQDFFPSMAMKANPQCDDRHCRRQQDEYKKKEAERPKQEVVQEEEEVVHEDNEWGIELVSEVTEAELQDASGPIPDLPEGITVAYTIPEKDGGSGETVEETEQSLEELMAQMKKI

UBA5

Ubiquitin-like modifier-activating enzyme 5

397 amino acids

E1-like enzyme which activates UFM1 and SUMO2.

Belongs to the ubiquitin-activating E1 family. UBA5 subfamily.

44.178 kDa

MAERVELLERRVRELERELELARGGRASARARIETMSPEVTDSNPYSRLMALKRMGIVKDYEKIRTFTVAIVGVGGVGSVTAEMLTRCGIGKLLLFDYDKVELANMNRLFFQPHQAGLSKVQAAEHTLRNINPDVQFEVHNYNITTLDNFEHFMDRISNGALEEGKPVDLVLSCVDNFEARMAINTACNELGQIWMESGVSENAVSGHIQLIIPGESACFACAPPLVVAANIDEKTLKREGVCAASLPTTMGVVAGILVQNVLKYLLNFGTVSYYLGYNAMQDFFPTMAMKPNPQCSDQNCRKQQENYKIKEAAQPKQEEIHQEEEIVHEDNDWGIELVSETTEDELKAASGPVPDLPVGITVAYTIPNKEENLTAEETVAESEESLEDLMAKMRNL

uba5

Ubiquitin-like modifier-activating enzyme 5

397 amino acids

E1-like enzyme which activates ufm1 and sumo2.

Belongs to the ubiquitin-activating E1 family. UBA5 subfamily.

44.169 kDa

MEGLIEELRSRVRELEEELDRVRNGQHEGHRTKIEKMSAEVVDSNPYSRLMALKRMGIVENYEKIRTFTVAVVGVGGVGSVTAEMLTRCGIGKLLLFDYDKVELANMNRLFFQPHQAGLSKVEAAEHTLRNINPDVQFEVHNYNITTLDNFQHFMDRISKGGLKEGSPVDLVLSCVDNFEARMAINTACNELGQVWMESGVSENAVSGHIQLIKPGETACFACAPPLVVAANIDEKTLKREGVCAASLPTTMGVVAGILVQNVLKYLLNFGTVSFYLGYNAMQDFFPTMAMKPNPQCDDKYCRKQQEEFKLKEAAKPKQETVVVEEEEVVHEDNDWGIELVSEVSEEELKAASGPVPDLPEGIKVAYTIPITKPTSGFTVEDSEQSLDELMAQMKNL

uba5

Ubiquitin-like modifier-activating enzyme 5

381 amino acids

E1-like enzyme which activates ufm1.

Belongs to the ubiquitin-activating E1 family. UBA5 subfamily.

42.617 kDa

MATPYREKIEKMSSEVIDSNPYSRLMALKKMGIVNNYENIRNLSVIIVGLGGIGSVAAEMLTRCGIGKLLLFDYDTVEIANMNRLFFRPEQSGKSKTMAAQETLSSINPDVQFESHNYNITTIDNFEHFKGRIEKGGLVEGEPVDLVLGCVDNFEARTAINQACLELGKSWMESGVSENAISGHIQLIIPGESACFQCVPPLIVASGIDERTLKREGVCAASLPTTMGIVAGMLVQNTLKYLLKFGEVSSLLGYNALLDYFPKDNMKPNPECSNSFCIIHQQKYKEFLKNNPKENLIQNNNNNNINNNEKKSTYENEWGIELIETSEDFNNNNNNNNKPSNNSFEFSYDKKPTVELNEQSTVKVNSSSNLEDLMNQLKNMK