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U74

Gene
U74
Protein
DNA helicase/primase complex-associated protein
Organism
Human herpesvirus 6A (strain Uganda-1102)
Length
662 amino acids
Function
Component of the helicase/primase complex. Unwinds the DNA at the replication forks and generates single-stranded DNA for both leading and lagging strand synthesis. The primase synthesizes short RNA primers on the lagging strand that the polymerase presumably elongates using dNTPs. The primase-associated factor has no known catalytic activity in the complex and may serve to facilitate the formation of the replisome by directly interacting with the origin-binding protein and the polymerase.
Similarity
Belongs to the herpesviridae HEPA family.
Mass
76.316 kDa
Sequence
MHLRGCACHLSLYCVYNDWENKIYRVPIFQCLFLEAETRSLKTFLIRGQSLDQESLNEIEVTRKETMLWDLQEQSNMMDKKIAAISNLIMNNGELVRTLSKFFVPLTVVLGDDGLEILEAYVCGEELMLPLDTVPVILRCIGDYAALDTKHLLSNECTQASKKIRFGYSVMDFHFSLTVSDVKICFSHTDTGEAVCEKMKQIFSFSVCAFGGEQVLLVTPKNAYALLFDDDLCLLLLQSVFAFLHEKIFGVYKQVLVQLCEYIGPDLWPFGNERSVSFIGYPNLWLLSVSDLERRVPDTTYICREILSFCGLAPILGPRGRHAVPVVRELSIEMPGSETSLQRFRFNSQYVSSESLCFQTGPEDTHLFFSDSDMYVVTLPDCLRLLLKSTVPKAFLPCFDENATEIDLLLKFMSRLQHRSYALFDAVIFMLDAFVSAFQRACTLMGMRWLLVRDLHMFYLTCDGKDTHVVMPLLQTAVENCWEKTTEIKQRPTFQCAEISRCGFIVYARFFLSSGLSQSKEAHWTVTASKYLSACIRTNKTGLCFASITVYFQDMMCVFIANRYNVSYWIEEFDPNDYCLEYHEGLLDCSRYTAVMSEDGQLVRQARGIALTDKINFSYYILVTLRVLRRWVESKFEDVEQTQFIRWENRMLCEHIHLLHLN

Gene
U74
Protein
DNA helicase/primase complex-associated protein
Organism
Human herpesvirus 6B (strain Z29)
Length
662 amino acids
Function
Component of the helicase/primase complex. Unwinds the DNA at the replication forks and generates single-stranded DNA for both leading and lagging strand synthesis. The primase synthesizes short RNA primers on the lagging strand that the polymerase presumably elongates using dNTPs. The primase-associated factor has no known catalytic activity in the complex and may serve to facilitate the formation of the replisome by directly interacting with the origin-binding protein and the polymerase.
Similarity
Belongs to the herpesviridae HEPA family.
Mass
76.55 kDa
Sequence
MHLRGCACHLSLYCVYNDWENKIYRVPIFQCLFLEAETRSLKTFLIRGQSLDQESLNEIEVTRKETMLWDLQEQSNMMDKKIAAISSLIMNNGELLRKLSKFFVPLTVVLGDDGLEILEAYVCGEEPMLPLDTVPVILRCVGDYAALDTKHLLSNECTQASKKLRFGYSVMDFHFSLTVSDVKICFSHTDTGEAVCEKMKQIFYFSVCAFGGEQVLLVTPKNAYALLFDDDLCLLLLQSVFAFLHEKIFAVYKQVLVQLCEYIGPDLWPFGNERSVSFIGYPNLWLLSVSDLERRVPDTTYICREILSFCGLAPILGPRGRHAIPVIRELSVEMPGSETSLQRFRFNSQYVSSESLCFQTGPEDTHLFFSDSDMYVVTLPDCLRLLLKSTVPRAFLPCFDENATEIELLLKFMSRLQHRSYALFDAVIFMLDAFVSAFQRACTLMEMRWLLVRDLHVFYLTCDGKDSHVVMPLLQTAVENCWEKITEIKQRPAFQCMEISRCGFVFYARFFLSSGLSQSKEAHWTVTASKYLSACIRANKTGLCFASITVYFQDMMCVFIANRYNVSYWIEEFDPNDYCLEYHEGLLDCSRYTAVMSEDGQLVRQARGIALTDKINFSYYILVTLRVLRRWVESKFEDVEQAEFIRWENRMLYEHIHLLHLN

Gene
U74
Protein
DNA helicase/primase complex-associated protein
Organism
Human herpesvirus 7 (strain JI)
Length
659 amino acids
Function
Component of the helicase/primase complex. Unwinds the DNA at the replication forks and generates single-stranded DNA for both leading and lagging strand synthesis. The primase synthesizes short RNA primers on the lagging strand that the polymerase presumably elongates using dNTPs. The primase-associated factor has no known catalytic activity in the complex and may serve to facilitate the formation of the replisome by directly interacting with the origin-binding protein and the polymerase.
Similarity
Belongs to the herpesviridae HEPA family.
Mass
77.028 kDa
Sequence
MQMRGCVCHLGVYCVHNDWKNKQYRVPIYQCLFFNAETHSLHTFLVIGNEISENLLDKISISKEKIFMWDLNEQIMSITQKTESICELMFGNKQIIQKLSRTFIFLTIILNSNMYEIIDVCIDSNAVLYMPDLRPMIIRCVGNYSKISSELLSDSDCTQATKKMRFDYHVTNFCFSLNVNGKKVLFSSTESSESILEKLLEFFTIQTYKLAEEQFLMVTPKNFFTVLFDEDMCLLLLQTVVSFLYDNLFRNKLVVKQVHDYIGPDLWPQGHERAVYFVGFPNMWFLSIYDLDNKIPCIKNICNRILLYCGLPDSLGPDGCQSVPSTQCVDEFEDLPNLGALQYLKYNSLVVTMETVENSENVYYFFGEQDLFIVKLVDIIQSLLELYVPKSFLPDFSDAYIKSEILLKFISRLHKKSNNIFCKIVKKITEFLRCFLNACRLMDLNWMFIRNMHIVYFIGPKKDPSVVLPLLKTSVESCWKKILNSSRTPVVNINYIPGYNFLHSSCSFLTSGDINSEDSHWTITASKCLYNCLGASQITVDFKNIYTNFQQMVSVFLSHRYENKYWIEYFEPNNYFLETHEGLLDCNRYTAVWTTENKLIRQSVGYPLTDKIDFIHYIQVVIEIFKKWLLTKYSQQEYAETVRLGSKIISDHLHLFNVN