U19

Gene

U19

Protein

Apoptosis inhibitor U19

Organism

Human herpesvirus 6A (strain Uganda-1102)

Length

389 amino acids

Function

Plays a role in the inhibition of host apoptosis to facilitate efficient viral replication. Promotes stabilization and inactivation of host TP53 through interaction with host MDM2.

Similarity

Belongs to the beta-herpesvirinae UL38 protein family.

Mass

43.316 kDa

Sequence

MAFTGDELARMLQFKDKMISSAGLALKFEKVVQEAMASGIVLQHITCIKVRICDNSDILSDRQLRSLLINGLYPFEGRMSMFGVTEEWEGASAAPERQVVFLLSSTGQVLGYEDGVVFYLSPTFSDFWTTAMEFSCQNAILSNFIAQKSRDEYIDQFQKYFTRMRHTPIFLTGVLPRRFQKVESSACVEEDARASMRPIQCDSFGVKDTFCRPTEELLQPSANKDVGGKVCMSLSCREDNSARHCTIYGLTETRGIKIMFSRHTQTDRSEVMCNAATQTGDVVDNSSETLFLGKNLVHQSILETEVKTTAKNTFDVSNPRIDSVYDTTVFGAMATDDVGCENVQGGASLAQEKPLKGYCITATPSECKPNIHWLKSPEKTVQESAAVLR

Protein

Apoptosis inhibitor U19: U19

Gene

U19

Protein

Apoptosis inhibitor U19

Organism

Human herpesvirus 6B (strain Z29)

Length

389 amino acids

Function

Plays a role in the inhibition of host apoptosis to facilitate efficient viral replication. Promotes stabilization and inactivation of host TP53 through interaction with host MDM2.

Similarity

Belongs to the beta-herpesvirinae UL38 protein family.

Mass

42.901 kDa

Sequence

MAFTGDELARMLQFKDKMISSAGSALRFEKVVQEAMASGIVLQHITCIKVRICDNSDILSDRQLRCLLINGLYPFEGRMSMFGVTEEWEGASAAPERQVVFLLSSTGQVLGYEDGVIFYLSPTFSDFWTTAMEFSCQNAILSNFIAQKSRDEYSDQFQKYFTRMRHTPISLTGVLPRRFQKVESGACVEEDARASMRPIQSDSFGAKGPFCWPTEELLQPSAKKDVGGTVCMALSCQEDNSARHCTIYGLTKTPGIKIMLSRHTQTDRSEAMCDAATQTEDVVDNSSETLFLGGNLVHQSILETEVQATAKNTFDVSDPRIDSVYDTTVVGAMATDDVGCKHVQGGASLAQEKPLKGYCIIATPSECKPNIHWLKSPENAVHESAAVLR

Protein

Apoptosis inhibitor U19: U19