Function
Toll-related receptor which binds to the neurotrophin spz5 (PubMed:10973475, PubMed:23892553). Functions in olfactory circuit assembly by promoting synaptic partner matching between olfactory receptor neurons (ORN) axons and projection neurons (PN) dendrites partners in the antennal lobe (PubMed:25741726). Involved in the targeting of specific classes of PN dendrites (Va1d, Va1v, DC3 and DA1) (PubMed:25741726). Functions with Toll-7 to regulate motor axon targeting and neuronal survival in the central nervous system (CNS) (PubMed:23892553). Possibly functions with 18w and Toll-8 during convergent extension, to help direct proper planar cell polarity, cell intercalation and axis elongation (PubMed:25363762). Promotes heterophilic cell adhesion with 18w in vitro (PubMed:25363762). May be an upstream component of the NF-kappa-B (rel) regulatory cascade (PubMed:23892553).
Sequence
MIYYMLLILPVVLAQDQQHTTESLSTKHHQQQQLSHSNAIMGEAGVSNSQLMQPSTPARTLRPLTAGAGGDPSLYDAPDDCHFMPAAGLDQPEIALTCNLRTVNSEFDTTNFSVIPAEHTIALHILCNDEIMAKSRLEAQSFAHLVRLQQLSIQYCKLGRLGRQVLDGLEQLRNLTLRTHNILWPALNFEIEADAFSVTRRLERLDLSSNNIWSLPDNIFCTLSELSALNMSENRLQDVNELGFRDRSKEPTNGSTESTSTTESAKKSSSSSTSCSLDLEYLDVSHNDFVVLPANGFGTLRRLRVLSVNNNGISMIADKALSGLKNLQILNLSSNKIVALPTELFAEQAKIIQEVYLQNNSISVLNPQLFSNLDQLQALDLSMNQITSTWIDKNTFVGLIRLVLLNLSHNKLTKLEPEIFSDLYTLQILNLRHNQLENIAADTFAPMNNLHTLLLSHNKLKYLDAYALNGLYVLSLLSLDNNALIGVHPDAFRNCSALQDLNLNGNQLKTVPLALRNMRHLRTVDLGENMITVMEDSAFKGLGNLYGLRLIGNYLENITMHTFRDLPNLQILNLARNRIAVVEPGAFEMTSSIQAVRLDGNELNDINGLFSNMPSLLWLNISDNRLESFDYGHVPSTLQWLDLHKNRLSSLSNRFGLDSELKLQTLDVSFNQLQRIGPSSIPNSIELLFLNDNLITTVDPDTFMHKTNLTRVDLYANQITTLDIKSLRILPVWEHRALPEFYIGGNPFTCDCNIDWLQKINHITSRQYPRIMDLETIYCKLLNNRERAYIPLIEAEPKHFLCTYKTHCFAVCHCCEFDACDCEMTCPTNCTCFHDQTWSTNIVECSGAAYSEMPRRVPMDTSELYIDGNNFVELAGHSFLGRKNLAVLYANNSNVAHIYNTTFSGLKRLLILHLEDNHIISLEGNEFHNLENLRELYLQSNKIASIANGSFQMLRKLEVLRLDGNRLMHFEVWQLSANPYLVEISLADNQWSCECGYLARFRNYLGQSSEKIIDASRVSCIYNNATSVLREKNGTKCTLRDGVAHYMHTNEIEGLLPLLLVATCAFVAFFGLIFGLFCYRHELKIWAHSTNCLMNFCYKSPRFVDQLDKERPNDAYFAYSLQDEHFVNQILAQTLENDIGYRLCLHYRDVNINAYITDALIEAAESAKQFVLVLSKNFLYNEWSRFEYKSALHELVKRRKRVVFILYGDLPQRDIDMDMRHYLRTSTCIEWDDKKFWQKLRLALPLPNGRGNNNKRVVSGCLSGRTPSVNMYATSHEYQAGNGGVIPPPSARYADCGSNNYATINECAAAGGGRGYKPIPTSASAAAAACKFNTMNQLSKKQQRDLSVAGMAKTLEHQHHHNHQANRRSQHEYAVPSYLPSAAPAYDSVDYAKQQIRNNANCECVNLGTAKRAAGKNPASGLPSSFSSNFVPPGGASYNCKKSCSCIGDDELLCSCGGGGGIGVNLLESGTQSSVTMSSSSNNSRQPELTHYESNLSLNDDEDEDHDQQKNLWA