About Products Protein Database Contact

Ta0325

Gene
Ta0325
Protein
dITP/XTP pyrophosphatase
Organism
Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
Length
187 amino acids
Function
Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.
Similarity
Belongs to the HAM1 NTPase family.
Mass
21.339 kDa
Sequence
MYRFVTSNRHKFEEVSEMAALYGIEIEWVRMKYEEIQDDSTERISYDSCNKLSRIVEAPYFVDDSGLFINALRGFPGPYSNYVSSTIGNEGILKIMDDVDDRTAYFLTVVSMNEGHSITQFIGKVMGKIARSIRGSNGFGYDPIFIPEGSDRTFAEMDIKAKNAISHRSIAFRGLFEYIKMNQTAKK