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TYW3

Gene
TYW3
Protein
tRNA wybutosine-synthesizing protein 3
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Length
273 amino acids
Function
S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72.
Similarity
Belongs to the TYW3 family.
Mass
30.806 kDa
Sequence
MAAQNAFEQKKRAILNEIDSTQPDLSPKGTIDELCLPIIDLINASADMVTTSSCSGRVSVFLEGTKSYNGEVKIGGKGQGGKWLYVTHDREKVIGWLDELKSKSEFSFELSGKEIPTEKVTGSIRYILYKYEPFILHVKCRDFQAASKLYNTAMSCGFRESGIGSNNLVAIRINIKLDVPLGYLDETSGTLKFFVTPEYVSVLDSLSLSKFDENTRKMQALYDRIEKELINCAPDVNSKVNITPIETKEERRERKKREGMERQRQLKSPQNVL

Gene
TYW3
Protein
tRNA wybutosine-synthesizing protein 3 homolog
Organism
Homo sapiens
Length
259 amino acids
Function
Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA (By similarity).
Similarity
Belongs to the TYW3 family.
Mass
29.794 kDa
Sequence
MDRSAEFRKWKAQCLSKADLSRKGSVDEDVVELVQFLNMRDQFFTTSSCAGRILLLDRGINGFEVQKQNCCWLLVTHKLCVKDDVIVALKKANGDATLKFEPFVLHVQCRQLQDAQILHSMAIDSGFRNSGITVGKRGKTMLAVRSTHGLEVPLSHKGKLMVTEEYIDFLLNVANQKMEENKKRIERFYNCLQHALERETMTNLHPKIKEKNNSSYIHKKKRNPEKTRAQCITKESDEELENDDDDDLGINVTIFPEDY

Gene
TYW3
Protein
tRNA wybutosine-synthesizing protein 3 homolog
Organism
Sus scrofa
Length
259 amino acids
Function
Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA (By similarity).
Similarity
Belongs to the TYW3 family.
Mass
29.48 kDa
Sequence
MDRRAEFKRWKAQCLSKADFSRKGCVDEDVVEIVQLLNGREQFFTTSSCAGRIILLEQGMDSLEVQKQNCCWLLVSHKPCVKDDVIVALKKANGDAILKFEPLVLHVQCRQLQDAQILHSVAIDSGFRNSGITVGKRGKTMLAVRSTHGLEVPLSHKGKLMVTEEYIDFLLKIANHKMEENKKRIERFYNCLQLALEKETTTTNSHPKEKIKEKNNSYKKKSNPGKAHDKCVTEENDKVLENDDDDDPGISVTIFPEDY

Gene
TYW3
Protein
tRNA wybutosine-synthesizing protein 3 homolog
Organism
Bos taurus
Length
258 amino acids
Function
Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA (By similarity).
Similarity
Belongs to the TYW3 family.
Mass
29.303 kDa
Sequence
MDLSAEFKRWKAQCLSKADLSRKGSVDEDVLEIVQLLNGQEQFFTTSSCAGRIILLDRSVNGSEVQKQNCCWLLVTHKACVKDDVIVALQKAKGDAILKFEPLVLHVQCRQLQDAQILHSVAIDSGFRNSGITVGKRGKTMLAVRSTHGLEVPLSHQGKLMVTEEYINFLLKIANQKMEENKKRIERFYHCLQHALEKETVSTTSQPKEKVNTSYIRKKKRNPGKARGKRVNEEHDKELENNDHDDPGISDTIFPEDY

Gene
TYW3
Protein
tRNA wybutosine-synthesizing protein 3 homolog
Organism
Pongo abelii
Length
258 amino acids
Function
Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA (By similarity).
Similarity
Belongs to the TYW3 family.
Mass
29.422 kDa
Sequence
MDRSAEFRKWKAQCLSKADLSRKGSVDEDVVELVQFLNMRDQFFTTSSCAGRILLLDGGINGFEVQKQNCCWLLVTHKLCVKDDVIVALKKANGDATLKFEPFVLHVQCRQLQDAQILHSVAIDAGFRNSGITVGKRGKTMLAVRSTHGLEVPLSHKGKLMVTEEYIDFLLNVANQKMEENKKRIERFYNCLQHALERETMTNLHPKIKEKNNSSYTHKKKNPEKACAQCITKENDKELENDDDDDLGINVTIFPEDY

Gene
Tyw3
Protein
tRNA wybutosine-synthesizing protein 3 homolog
Organism
Mus musculus
Length
257 amino acids
Function
Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA (By similarity).
Similarity
Belongs to the TYW3 family.
Mass
28.575 kDa
Sequence
MDRSAEFGRWKAQSLSKADLSRKGSVDEDAVEVVELLNSREEFFTTSSCAGRILLLDGSTEGSGVQKQHCCWLLVTHKPCARDDVMAALKGATSEAVLKFEPFILHVQCRTLQDAQTLHSVAIDSGFRNSGITVGKRGKTMLAVRGTHGLEVPLTHKGKLMVTEEYIEFLLTIANQKMEENKRRIGRFYNYLQHALKRETISNSHSKIKERNNPLCTHKNRRSQGKAQGPSTTEDNGRELEDGDGLEISAALFLGDD

Gene
tyw3
Protein
tRNA wybutosine-synthesizing protein 3 homolog
Organism
Danio rerio
Length
251 amino acids
Function
Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA (By similarity).
Similarity
Belongs to the TYW3 family.
Mass
28.798 kDa
Sequence
MDGDSFQQWKNQCLNKCDFSKKGSVDEDISHVVSFINSQDRYFTTSSCSGRIILFDAVSDCPDVQKQNCSWLFVTHQKCQMEDVVRGLEKSVGDATFKFEPFVLHVQCKQLEDAQLLHTVAINSGFRNSGITVGKKGKIIMAVRSTHCLEVPLSHRSHVLVTHQYLDFLVGVANQKMEENLKRIQRFSECLQAALQPQEEKCSFKEADNKTVYRRRRKRTQDVSVTDSSQNTQEHHENTEEEIDCDLLFLL

Gene
tyw3
Protein
tRNA wybutosine-synthesizing protein 3 homolog
Organism
Xenopus laevis
Length
251 amino acids
Function
Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA (By similarity).
Similarity
Belongs to the TYW3 family.
Mass
28.693 kDa
Sequence
MEKQEAFSHWKQQSARKTDVSKKGSVDEDIEETVRLINQQERYFTTSSCSGRVIIINETLDNSTIQKQNCSWLFVTHKLCKPDDVFAALQNATGDVVLKFEPFVLHVQCRALEDAQLLHSVAINAGFRNSGITVGKKGKIIMAVRSTHGLEVPLTQNGKCLVSHEYIEFLVHTANKKMEENKRRITRFHSCLHKALQKEDCVHDKTSKEQASSCVYVRRRKRKDRSRKSNCSSSEEEHTDSEPELTLFNDP

Gene
tyw3
Protein
tRNA wybutosine-synthesizing protein 3
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Length
237 amino acids
Function
S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72 (By similarity).
Similarity
Belongs to the TYW3 family.
Mass
26.997 kDa
Sequence
MNIKGIDVSFDAQKKEILEGLKSSVPDASPKGHPDSPIFPLLDVINSHPDWVTTSSCSGRISVYVQGANSRKGGGYWLFVSHQAHEELPPVLEDEKVEYGKVPSSPVEGNREIQYAFEPMILHVQTRSLANAQHLQRVAASCGFRETGIQGSEQKFIVAIRTSLRMDIPIGCLTASEKLQFYITREYMCFLFKRSVEYFTENGNRMARLKEQLERQVEKRMKPRRKLRNMDDYLVQS