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TYRO3

Gene
TYRO3
Protein
Tyrosine-protein kinase receptor TYRO3
Organism
Homo sapiens
Length
890 amino acids
Function
(Microbial infection) Acts as a receptor for Ebolavirus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope.
Similarity
Belongs to the protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily.
Mass
96.905 kDa
Sequence
MALRRSMGRPGLPPLPLPPPPRLGLLLAALASLLLPESAAAGLKLMGAPVKLTVSQGQPVKLNCSVEGMEEPDIQWVKDGAVVQNLDQLYIPVSEQHWIGFLSLKSVERSDAGRYWCQVEDGGETEISQPVWLTVEGVPFFTVEPKDLAVPPNAPFQLSCEAVGPPEPVTIVWWRGTTKIGGPAPSPSVLNVTGVTQSTMFSCEAHNLKGLASSRTATVHLQALPAAPFNITVTKLSSSNASVAWMPGADGRALLQSCTVQVTQAPGGWEVLAVVVPVPPFTCLLRDLVPATNYSLRVRCANALGPSPYADWVPFQTKGLAPASAPQNLHAIRTDSGLILEWEEVIPEAPLEGPLGPYKLSWVQDNGTQDELTVEGTRANLTGWDPQKDLIVRVCVSNAVGCGPWSQPLVVSSHDRAGQQGPPHSRTSWVPVVLGVLTALVTAAALALILLRKRRKETRFGQAFDSVMARGEPAVHFRAARSFNRERPERIEATLDSLGISDELKEKLEDVLIPEQQFTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACMKEFDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQTLIRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLPVKWLALESLADNLYTVQSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQPPECMEDVYDLMYQCWSADPKQRPSFTCLRMELENILGQLSVLSASQDPLYINIERAEEPTAGGSLELPGRDQPYSGAGDGSGMGAVGGTPSDCRYILTPGGLAEQPGQAEHQPESPLNETQRLLLLQQGLLPHSSC

Gene
tyro3
Protein
Tyrosine-protein kinase receptor TYRO3
Organism
Xenopus tropicalis
Length
881 amino acids
Function
May be involved in cell adhesion processes, particularly in the central nervous system.
Similarity
Belongs to the protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily.
Mass
98.019 kDa
Sequence
MVNPGPPGLIAGLLLAALSLSSVDGTKALGFVGHGYNMTVSQGHEAKLNCSLQGMEEPEIQWLKDGVPVQSADQMYIPVDEDHWISFLSLKNVERPDAGRYWCEAEHSGRKSVSDAIWVMVEGVPYFTLEPKDLSVTPNSPFNMTCAAVGPPEPLVIFWWVGDSPLGKSESSPSVLQIPGIRERTAFSCEAHNAKGVSSSRTAIVEVKGLPYPPFNVTISKVTGSTATVTWSPGFNSFSLIKSCTIQVQSLHGNREMYSRLTSVPPFAVVLDDLQPLTNHSVRVQCTNEMGASPFSEWITFNTKEKVPQLIPQNVHMTKTDSCLLLDWEDVDPDKEGYNILGFKVQWEQENTTQGELFVQENQANLTKWNPEKDLTIRICIANAAGCGPWSEFLLAGSKEEAGKQRHPHTRMSWVPMVLGILTALVTVVAMTLIFLRKGRKETRFGNMLGSMLGRGGPVIQFTAARSFNRRGPEVMEATLDSIGISDELKSKLKDVLIQQQQFTLGRTLGKGEFGSVREAQLKMEDDTMQKVAVKMLKAEIFCSSDIEEFLREAAFMKEFDHPNVCKLIGVSLRSRTKGRLPVPMVILPFMKHGDLHTFLLMSRIGEEPIALPIQTLVRFMIDICSGMEYLSSKNFIHRDLATRNCMLNEDMTVCVADFGLSKKIYSGDYYRQGCASKLPVKWLALESLADNVYTVHSDVWAFGVTLWEIVTRGQTPYAGVENSEIYSYLTAGNRLKQPPDCLDELYEMMCQCWITEPKRRPSFVDLKRRLEAIWGRLSILSASHDQLYVNLGETCGAAAAVSGLHSAFCKEEDYCAGPSQTCGTSAITSDYRYIVNPGCLREGNEWSSSAQNGEARGLLHEEEEEEEEEEMQEEQVVITL

Gene
Tyro3
Protein
Tyrosine-protein kinase receptor TYRO3
Organism
Mus musculus
Length
880 amino acids
Function
Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with PIK3R1 and thereby enhances PI3-kinase activity. Activates the AKT survival pathway, including nuclear translocation of NF-kappa-B and up-regulation of transcription of NF-kappa-B-regulated genes. TYRO3 signaling plays a role in various processes such as neuron protection from excitotoxic injury, platelet aggregation and cytoskeleton reorganization. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.
Similarity
Belongs to the protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily.
Mass
96.208 kDa
Sequence
MALRRSMGWPGLRPLLLAGLASLLLPGSAAAGLKLMGAPVKMTVSQGQPVKLNCSVEGMEDPDIHWMKDGTVVQNASQVSISISEHSWIGLLSLKSVERSDAGLYWCQVKDGEETKISQSVWLTVEGVPFFTVEPKDLAVPPNAPFQLSCEAVGPPEPVTIYWWRGLTKVGGPAPSPSVLNVTGVTQRTEFSCEARNIKGLATSRPAIVRLQAPPAAPFNTTVTTISSYNASVAWVPGADGLALLHSCTVQVAHAPGEWEALAVVVPVPPFTCLLRNLAPATNYSLRVRCANALGPSPYGDWVPFQTKGLAPARAPQNFHAIRTDSGLILEWEEVIPEDPGEGPLGPYKLSWVQENGTQDELMVEGTRANLTDWDPQKDLILRVCASNAIGDGPWSQPLVVSSHDHAGRQGPPHSRTSWVPVVLGVLTALITAAALALILLRKRRKETRFGQAFDSVMARGEPAVHFRAARSFNRERPERIEATLDSLGISDELKEKLEDVLIPEQQFTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACMKEFDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQTLVRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLPVKWLALESLADNLYTVHSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQPPECMEEVYDLMYQCWSADPKQRPSFTCLRMELENILGHLSVLSTSQDPLYINIERAEQPTESGSPEVHCGERSSSEAGDGSGVGAVGGIPSDSRYIFSPGGLSESPGQLEQQPESPLNENQRLLLLQQGLLPHSSC

Gene
Tyro3
Protein
Tyrosine-protein kinase receptor TYRO3
Organism
Rattus norvegicus
Length
880 amino acids
Function
Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with PIK3R1 and thereby enhances PI3-kinase activity. Activates the AKT survival pathway, including nuclear translocation of NF-kappa-B and up-regulation of transcription of NF-kappa-B-regulated genes. TYRO3 signaling plays a role in various processes such as neuron protection from excitotoxic injury, platelet aggregation and cytoskeleton reorganization. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3 (By similarity).
Similarity
Belongs to the protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily.
Mass
95.919 kDa
Sequence
MALRRSMGRPGLRPLLLAGLASLLLPGSAAAGLKLMGAPVKMTVSQGQPVKLNCSVEGMDDPDIHWMKDGAVVQNASQVSISISEQNWIGLLSLKSAERSDAGLYWCQVKDGEETKISQSVWLTVEGVPFFTVEPKDLAVPPNVPFQLSCEAVGPPEPVTIFWWRGPTKVGGPASSPSVLNVTGVTQRTEFSCEAHNIKGLATSRPAIIRLQAPPAAPFNITVTTISSSNASVAWVPGADGLALLHSCTVQVAHAPGEWEALAVVVPVPPFTCLLRNLAPATNYSLRVRCANALGPSPYGDWVPFQTKGLAPARAPQNFHAIRTDSGLILEWEEVIPEDPGEGPLGPYKLSWVQENGTQDELMVEGTTANLTDWDPQKDLVLRVCASNAIGDGPWSQPLVVSSHDHAGRQGPPHSRTSWVPVVLGVLTALITAAALALILLRKRRKETRFGQAFDSVMARGEPAVHFRAARSFNRERPERIEATLDSLGISDELKEKLEDVLIPEQQFTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACMKEFDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQTLVRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLPVKWLALESLADNLYTVHSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLISGNRLKQPPECMEEVYDLMYQCWSADPKQRPSFTCLRMELENILGHLSVLSTSQDPLYINIERAGQPAENGSPELPCGEQSSSEAGDGSGMGAIGGIPSDCRYIFSPGGLAESPGQLEQQPESPLNENQRLLLLQQGLLPHSSC

Gene
tyro3
Protein
Tyrosine-protein kinase receptor TYRO3
Organism
Xenopus laevis
Length
880 amino acids
Function
May be involved in cell adhesion processes, particularly in the central nervous system.
Similarity
Belongs to the protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily.
Mass
97.934 kDa
Sequence
MVYPGPPGLIAGLLLAALSLSCVDGAKALGFVGHGYNLTVSQGHEAKLNCSLQGIEEPEIQWLKDGVPVQSADQMYIPVDEDHWISFLSLKNVERPDAGKYWCEAEHSGRKSVSDAIWIMVEGVPYFTLEPKDLSVTPNSPFNMTCAAVGPPEPLVIIWWVGDSPLGKSESSPSVLQMSGIHERTAFSCEAHNAKGVSSSRTAIVEVKGLPYPPFNVTISKVTGSTATVTWFPGFNSFSLIKSCTIQVQSLHGNREMYSRLISAPPFAVLLDELQPLTNHSVRVQCTNEMGASPFTEWRTFHTKETVPQLLPQNVHMTKTETSLLLDWEEVEPDREGYNILGFKVQWEQENATQGELFVQENQANLTKWNPEKDLTIRICIANAAGCGPWSEFLLAGSKEEAGKQRHPHTRMSWVPMVLGILTALVTVVAMTLIFLRKGRKETRFGNMLGSMLGRGGPVIQFTAARSFNRRGPEMMEATLDSIGISEELKSKLKDVLIQQQQFTLGRTLGKGEFGSVREAQLKMEDDTMQKVAVKMLKAEIFCSSDIEEFLREAAFMKEFDHPNVCKLIGVSLRSRTKGRLPVPMVILPFMKHGDLHTFLLMSRIGEEPITLPVQTLVRFMIDICSGMEYLSSKNFIHRDLATRNCMLNEDMTVCVADFGLSKKIYSGDYYRQGCASKLPVKWLALESLADNVYTVHSDVWAFGVTLWEIATLGQTPYAGVENSEIYSYLIAGNRLKQPLDCLDELYEMMCQCWITEPKRRPSFVDLKQRLEAIWGRLSILSASQDQLYVNLGETCGAAAAVSGLHSAFCSEEDYCAGPSQTCGTSAITSDYRYIVNPGCLREGNEWSSSAQNGEARGLLHEEEEEEEEEMQEEQVVITL

Gene
tyro3
Protein
Tyrosine-protein kinase receptor TYRO3
Organism
Danio rerio
Length
874 amino acids
Function
May be involved in cell adhesion processes, particularly in the central nervous system.
Similarity
Belongs to the protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily.
Mass
97.599 kDa
Sequence
MEVSLCILLFLLHFNEGIHGVRFTQKPFHQTVTQGNMVRLGCAFEGLSEPEIIWMKDGEKLFSTDQMYITLDPYHWETFHSVKSVQQQDAGKYWCEVEYHGAIISSEPAWITVAGVPHFGVEPEDVAAFAGESFNLTCAASGPPEPVEVLWWLGGEQNGDFTPSPSVLFVKGVNESIKFHCEPRNARGISVSRTGTVHIKARPDSLGRTGHHVSDFNITLTWSPGFTGHSQLSTCTIQLSRGPGEVKLPDVVVEVPPFQHVFEGLRSYSNYSVRVRCDNEVGSSPFSPWVDFHTPQAAPSAAPKNFTFDLSEQQLTLSWATLEQEELRGRLQEELRGRLLAYKLQWNQGGESQDPLLFKENVAHLSGAGRFFNATFQVAACTMAGCGPWSQPVLVMPVSAMQAQTQRGHMWVGLLFGLLVATMVGLLLIVLIRNRGKETQFGSAFAAQGAEVPVSFTAARSFNRQFPELPESTLDSLGINSDLKAKLQDVLIFERLLTLGRMLGKGEFGSVREAFLKSENNSGQKVAVKVLKTDINSSSDIEQCLKEAAYMKDFHHPNVIQLIGVSLHRRAQQRLPIPMVILPFMKHGDLHTFLLMSRLGDEPFTVSQQILIQFMLDIARGMEYLSNKNIIHRDLAARNCMLNENMSVCVADFGLSKKIYSGDYYRQGSVSKLPVKWIALESLADNVYTTQSDVWAFGVTMWEIMTRGQTPYPGVENSEIYEYLIKGERLKQPPDCPADIYEIMHSCWSPVPKCRPSFQHLIDQLELLWAKLNPAPVKEPLLYVNLEEEDGEQANSGTRSSEEPSWGVPWQCAGIEEDEKDWLMVSSGAALAIGGDYRYIIGPSVSAIDEESRHSEDGLSEDIREEEEDVIINV

Gene
TYRO3
Protein
Tyrosine-protein kinase receptor TYRO3
Organism
Gallus gallus
Length
873 amino acids
Function
Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, enhances PI3-kinase activity and activates the AKT survival pathway, including nuclear translocation of NF-kappa-B and up-regulation of transcription of NF-kappa-B-regulated genes (By similarity).
Similarity
Belongs to the protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily.
Mass
96.402 kDa
Sequence
MELRRSMALPRLLLLGLWAAALRDGAVAAGMKFTGSPIKLKVSQGQPVKLNCSLEGMEDPEMLWIKDGAVVQSVDQVYIPVDEDHWIGFLSLKSVERTDSGKYWCQVENGGKKEESQQVWLIVEGVPYFTVEPEDVSVSPNAPFHMACAAVGPPEPVTIVWWMGDSRVGLPDISPSILNVSGINQSTMFSCEAHNVKGLSSSRTATVQIKAMPLPPLNVTVSQVTSSNASVVWVPGFDGRAPLHSCTLQVAESPDGQEVSTEVAPVPPFAYGVQGLKHSTNYSVRVQCSNEMGSSPFTERVYFQTLELAPSSTPQNIHVIQRDPGLVLEWEGVAPDVLKENVLGYRLEWIQDNVTQGEMIVQDTKANLTTWNPLKDLIIRVCVLNSAGCGPWSDLFLLEAQEVMGGQRQPPYGTSWVPVALGILTALVTAVALALILLRKRRKETRFGHAFGSVVGRGDPAVHFRAARSFNREGPELIEATLESVGISDELKTKLKDVLIQEQQFTLGRMLGKGEFGSVREALLKLDDGSFQKVAVKMLKADIFTSTDIEEFLREAACMKEFDHPHVTKLIGVSLRSRPKGRLPIPMVILPFMKHGDLHAFLLMSRIGENPFNLPLQTLLKFMIDIASGMEYLSSKNFIHRDLAARNCMLDENMNVSVADFGLSKKIYSGDYYRQGCASKLPVKWLALESLADNLYTTHSDVWAFGVTMWEIVTRGQTPYAGIENAEIYNYLISGNRLKQPPECLEDVYDLMCRCWHPEPKLRPSFGVLRSQLEMIRGRMSTLSLSQDPLYVNIGKDKESSVSDPAVHTSFGNTDGDETIAGAAAAAITSDYRYIMSPLCLGDDVEGERHPEGQEGENKSLLYELETEGEKSC