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TYR

Gene
TYR
Protein
Tyrosinase
Organism
Podospora anserina
Length
574 amino acids
Function
This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds.
Similarity
Belongs to the tyrosinase family.
Mass
64.181 kDa
Sequence
MSTTGNIAITGIPTTAGPDGSFPLRRELRDLQRNYPDHFNLLVLALKDFQALNESVQTSYYQIAGIHGLPYKPWNNVGSNSDWQSTSGFGGYCTHSSILFLTWHRPYLALFEQALYNSIQKIANQFPQGPLRTKYVEAAKTFRMPYFDWASQPPSGSSAFPSAFTAPSLQVVDVDGKTKSTANPIYRFVFHPVNPSPGDFPRQWSRFPTTVRYPNPRTGQSQDNRVAPILANELASLRTNVSLLLLSYTNFDAFSFNRWDPNMTPGEFGSLEDVHNEIHDRTGGGGHMSSLDVSSFDPLFWFHHTNVDRLWAIWQDLNPDNFLTPRPAPYSTFNSTEGESQTKDTPLTPFWDKSATKFWTSEEIKDTTTTFGYAYPETQEWKYRTGSEYQTSIRQAVTTLYGTNVFANFAAANVQARATEHTELIKSLSLAAPPPSAPITAEKPLLITQEMKASPIPEHLQHLAPNNKYPEWVVNIRAQKHGLHGAFRVIVFLGPIDESDPDSWQTEFNTVGRVSVLGRSTQGPTTTKCAKCITDAADELMISGTVPLTSALLQDIVNENTASIACSQRKWCRI

Gene
tyr
Protein
Tyrosinase
Organism
Oryzias latipes
Length
540 amino acids
Function
This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds.
Similarity
Belongs to the tyrosinase family.
Mass
61.254 kDa
Sequence
MKSLFLSAVLLQFFETCWSQFPRPCANSEGLRTKECCPVWSGDGSPCGALSGRGFCADVSVSDEPNGPQYPHSGIDDRERWPLAFFNRTCRCAGNYGGFNCGECRFGYWGSNCAEYRESVRRNIMSMSTTEQQKFISYLNLAKNTINPDYVITTGTRAEMGENGESPMFSDINTYDLFVWIHYYVSRDTFLGGPGNVWRDIDFAHESAAFLPWHRVYLLHWEQEIRKITGDFNFTIPYWDWRDAQSCEVCTDNLMGGRNALNPNLISPASVFSSWKVICTQQEEYNNQEALCNATAEGPLLRNPGNHDPNRVPRIPTTADVEFTISLPEYETGSMDRFANNSFRNVLEGFASPETGMAVQGQSTMHNALHVFMNGSMSSVQGSANDPIFLLHHAFIDSIFERWLRTHQPPRSIYPRTNAPIGHNDGYYMVPFLPLYRNGDYLLSNKALGYEYAYLLDPGQRFVQEFLTPYLQQAQQIWQWLLGAGILGALIATIVAAVIVFARRKRRRNQKRKRAPSFGERQPLLQSSSEEGSSSYQTTL

Gene
Tyr
Protein
Tyrosinase
Organism
Mus musculus
Length
533 amino acids
Function
This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine. In addition to hydroxylating tyrosine to DOPA (3,4-dihydroxyphenylalanine), also catalyzes the oxidation of DOPA to DOPA-quinone, and possibly the oxidation of DHI (5,6-dihydroxyindole) to indole-5,6 quinone (PubMed:2494997, PubMed:2517217, PubMed:1537333).
Similarity
Belongs to the tyrosinase family.
Mass
60.606 kDa
Sequence
MFLAVLYCLLWSFQISDGHFPRACASSKNLLAKECCPPWMGDGSPCGQLSGRGSCQDILLSSAPSGPQFPFKGVDDRESWPSVFYNRTCQCSGNFMGFNCGNCKFGFGGPNCTEKRVLIRRNIFDLSVSEKNKFFSYLTLAKHTISSVYVIPTGTYGQMNNGSTPMFNDINIYDLFVWMHYYVSRDTLLGGSEIWRDIDFAHEAPGFLPWHRLFLLLWEQEIRELTGDENFTVPYWDWRDAENCDICTDEYLGGRHPENPNLLSPASFFSSWQIICSRSEEYNSHQVLCDGTPEGPLLRNPGNHDKAKTPRLPSSADVEFCLSLTQYESGSMDRTANFSFRNTLEGFASPLTGIADPSQSSMHNALHIFMNGTMSQVQGSANDPIFLLHHAFVDSIFEQWLRRHRPLLEVYPEANAPIGHNRDSYMVPFIPLYRNGDFFITSKDLGYDYSYLQESDPGFYRNYIEPYLEQASRIWPWLLGAALVGAVIAAALSGLSSRLCLQKKKKKKQPQEERQPLLMDKDDYHSLLYQSHL

Gene
Tyr
Protein
Tyrosinase
Organism
Pelophylax esculentus
Length
532 amino acids
Function
This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds (By similarity). Catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine. In addition to hydroxylating tyrosine to DOPA (3,4-dihydroxyphenylalanine), also catalyzes the oxidation of DOPA to DOPA-quinone (PubMed:19101648, PubMed:18950728, PubMed:6798971).
Similarity
Belongs to the tyrosinase family.
Mass
60.334 kDa
Sequence
MESTTVLLAASTLLLVLHASYGQFPRACSTAQVLLSKECCPVWPGDNSSCGEVSGRGVCQDVVPSNSPVGAQFPFSGIDDRENWPIVFYNRTCQCQGNFMGYNCGECRFGYTGPNCTVRRNMIRKEIFRMTTAEKDKFIAYLNLAKRTISQDYVISTGTYEQMNNGSNPMFADINVYDLFVWLHYYASRDAFLEDGSVWANIDFAHEAPGFPPWHRFFLLLWEREIQKVAADDNFTIPFWDWRDAQQCDLCTDEFFGGTHPTSNNLLSPASFFSSWQVICSQPEEYNRLRIICNGTNEGPLLRSPGRHDRNRTPRLPTSADVEACLSLTDYETGAMDRFANFSFRNTLEGYAVPASGIANRSQSNMHNSLHVFMNGSMSNVQGSANDPIFVLHHAFVDSLFEQWLRRHQPSLDVYPEANAPVGHNREYNMVPFIPLFTNGEFFVQSRDLGYDYDYLAESGSIEDFLLPYLEQARQIWQWLLGAAVVGGLVTAVIATIISLTCRRKRRTKTSEETRPLLMEAEDYHATYQSNL

Gene
TYR
Protein
Tyrosinase
Organism
Pelophylax nigromaculatus
Length
532 amino acids
Function
This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds (By similarity). Catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine. In addition to hydroxylating tyrosine to DOPA (3,4-dihydroxyphenylalanine), also catalyzes the oxidation of DOPA to DOPA-quinone (By similarity).
Similarity
Belongs to the tyrosinase family.
Mass
60.116 kDa
Sequence
MESTTVLLATSTLLLVLHASYGQFPRACSTAQVLLSKECCPVWPGDNSSCGEVSGRGVCQDVVPSNSPVGAQFPFSGIDDRENWPIVFYNRTCQCQGNFMGYNCGECRFGYTGPNCTVRRNMIRKDIFRMTTAEKDKLIAYLNLAKHTISPDYVIATGTYEQMNNGSNPMFADISAYDLFVWIHYYASRDAFLEDGSVWADIDFAHEAPGFLPWHRFYLLLWEREIQKVTGDDNFTIPFWDWRDAQQCELCTDEFFGGTHPTSNNLLSPASFFSSWQIICSRPEEYNSLRIICNGTNEGPLLRSPGRHDRNRTPRLPTSADVEACLSLTDYETGAMDRSANFSFRNTLEGFAVPTSGIANRSQSSMHNSLHVFLNGSMSSVQGSANDPIFVLHHAFVDSLFEQWLRRHQPSLDVYPEANAPVGHNREYNMVPFIPLFTNGEFFVQSRDLGYDYDYLAESGSIEDFLLPYLEQARQIWQWLLGAAVLGGLITAVIATIISLTCRRKRKTKISEETRPLLMEAEDYQATYQSNL

Gene
TYR
Protein
Tyrosinase
Organism
Canis lupus familiaris
Length
530 amino acids
Function
This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine. In addition to hydroxylating tyrosine to DOPA (3,4-dihydroxyphenylalanine), also catalyzes the oxidation of DOPA to DOPA-quinone, and possibly the oxidation of DHI (5,6-dihydroxyindole) to indole-5,6 quinone.
Similarity
Belongs to the tyrosinase family.
Mass
60.336 kDa
Sequence
MLLAALCCLLWSFRTSTGHFPRACASSKSLMEKECCPPWSGDGSPCGQLSGRGACQDIILSNAPFGPQFPFTGVDDRESWPSVFYNRTCQCFGNFMGFNCGNCKFGFWGQNCTEKRLLVRKNIFDLSVPEKNKFLAYLTLAKHTTSPDYVIPTGTYGQMNNGSTPMFNDINIYDLFVWMHYYVSRDTLLGGSEIWKDIDFAHEAPGFLPWHRLFLLLWEQEIQKLTGDENFTIPYWDWRDAKSCDICTDEYMGGRNPANPNLLSPASFFSSWQIVCTRLEEYNSRQALCDGTPEGPLLRNPGNHDKARTPRLPSSADVEFCLSLTQYESDSMDKAANFSFRNTLEGFASPLTGIADASQSSMHNALHIYMNGTMSQVPGSANDPIFLLHHAFVDSIFEQWLRRHHPLREVYPEANAPIGHNRESYMVPFIPLYRNGDLFISSRDLGYDYSNLQESERDIFQDYIKPYLEQASRIWPWLIGAAVVGCVVTAVLGGLTSLLCRRNRKQLHEEKQPLLMEKEDYHSLLYQTHL

Gene
TYR
Protein
Tyrosinase
Organism
Bos taurus
Length
530 amino acids
Function
This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine. In addition to hydroxylating tyrosine to DOPA (3,4-dihydroxyphenylalanine), also catalyzes the oxidation of DOPA to DOPA-quinone, and possibly the oxidation of DHI (5,6-dihydroxyindole) to indole-5,6 quinone.
Similarity
Belongs to the tyrosinase family.
Mass
60.304 kDa
Sequence
MLLAALYCLLWSFRTSAGHFPRACASSKSLTEKECCPPWAGDGSPCGRLSGRGSCQDVILSTAPLGPQFPFTGVDDRESWPSIFYNRTCQCFSNFMGFNCGSCKFGFRGPRCTERRLLVRRNIFDLSVPEKNKFLAYLTLAKHTTSPDYVIPTGTYGQMNHGTTPLFNDVSVYDLFVWMHYYVSRDTLLGDSEVWRDIDFAHEAPGFLPWHRLFLLLWEQEIQKLTGDENFTIPYWDWRDAENCDVCTDEYMGGRNPANPNLLSPASFFSSWQIVCSRLEEYNSRQALCNGTSEGPLLRNPGNHDKARTPRLPSSADVEFCLSLTQYESGSMDKAANFSFRNTLEGFADPVTGIADASQSSMHNALHIYMNGTMSQVPGSANDPIFLLHHAFVDSIFEQWLRKYHPLQDVYPEANAPIGHNRESYMVPFIPLYRNGDFFISSKDXGYDYSYLQDSEPDIFQDYIKPYLEQAQRIWPWLIGAAVVGSVLTAVLGGLTSLLCRRKRNQLPEEKQPLLMEKEDYHNLMYQSHL

Gene
TYR
Protein
Tyrosinase
Organism
Gallus gallus
Length
529 amino acids
Function
This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine. In addition to hydroxylating tyrosine to DOPA (3,4-dihydroxyphenylalanine), also catalyzes the oxidation of DOPA to DOPA-quinone, and possibly the oxidation of DHI (5,6-dihydroxyindole) to indole-5,6 quinone.
Similarity
Belongs to the tyrosinase family.
Mass
60.357 kDa
Sequence
MFLFAMGLLLVILQPSTGQFPRVCANTQSLLRKECCPPWDGDGTPCGERSNRGTCQRILLSQAPLGPQFPFSGVDDREDWPSVFYNRTCRCRGNFMGFNCGECKFGFSGQNCTERRLRTRRNIFQLTISEKDKFLAYLNLAKNIPSKDYVIATGTYAQMNNGSNPMFRNINVYDLFVWMHYYASRDTLLGGSNVWRDIDFAHEAPGFLPWHRAFLLLWEREIQKITGDENFTIPYWDWRDAEDCVICTDEYMGGQHPTNPNLLSPASFFSSWQVICTQSEEYNSQQALCNATSEGPILRNPGNNDKSRTPRLPSSSEVEFCLTLTQYESGSMDKMANYSFRNTLEGFADPHTAISNISQSGLHNALHIYMNGSMSQVQGSANDPIFILHHAFVDSIFERWLRRHRPMLEVYPAANAPIGHNRENYMVPFIPLYRNGEFFISSRELGYDYEYLQEPALGSFQDFLIPYLKQAHQIWPWLVGAAVIGGIITAVLSGLILACRKKRKGTSPEIQPLLTESEDYNNVSYQSHF

Gene
TYR
Protein
Tyrosinase
Organism
Gorilla gorilla gorilla
Length
529 amino acids
Function
This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine. In addition to hydroxylating tyrosine to DOPA (3,4-dihydroxyphenylalanine), also catalyzes the oxidation of DOPA to DOPA-quinone, and possibly the oxidation of DHI (5,6-dihydroxyindole) to indole-5,6 quinone.
Similarity
Belongs to the tyrosinase family.
Mass
60.365 kDa
Sequence
MLLAVLYCLLWSFQTSAGHFPRACVSSKNLMEKECCPPWSGDRSPCGQLSGRGSCQNILLSNAPLGPQFPFTGVDDRESWPSVFYNRTCQCSGNFMGFNCGNCKFGFWGPNCTERRLLVRRNIFDLSAPEKDKFFAYLTLAKHTISSDYVIPIGTYGQMKNGSTPMFNDINIYDLFVWMHYYVSMDALLGGSEIWRDIDFAHEAPAFLPWHRLFLLRWEQEIQKLTGDENFTIPYWDWRDAEKCDICTDEYMGGQHPTNPNLLSPASFFSSWQIVCSRLEEYNSHQSLCNGTPEGPLQRNPGNHDKSRTPRLPSSADVEFCLSLTQYESGSMDKAANFSFRNTLEGFASPLTGIADASQSSMHNALHIYMNGTMSQVQGSANDPIFLLHHAFVDSIFEQWLRRHRPLQEVYPEANAPIGHNRESYMVPFIPLYRNGDFFISSKDLGYDYSYLQDSDPDSFQDYIKSYLEQASRIWSWLLGAAMVGAVLTALLAGLVSLLCRHKRKQLPEEKQPLLMEKEDYHSLYQSHL

Gene
TYR
Protein
Tyrosinase
Organism
Homo sapiens
Length
529 amino acids
Function
This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine. In addition to hydroxylating tyrosine to DOPA (3,4-dihydroxyphenylalanine), also catalyzes the oxidation of DOPA to DOPA-quinone, and possibly the oxidation of DHI (5,6-dihydroxyindole) to indole-5,6 quinone.
Similarity
Belongs to the tyrosinase family.
Mass
60.393 kDa
Sequence
MLLAVLYCLLWSFQTSAGHFPRACVSSKNLMEKECCPPWSGDRSPCGQLSGRGSCQNILLSNAPLGPQFPFTGVDDRESWPSVFYNRTCQCSGNFMGFNCGNCKFGFWGPNCTERRLLVRRNIFDLSAPEKDKFFAYLTLAKHTISSDYVIPIGTYGQMKNGSTPMFNDINIYDLFVWMHYYVSMDALLGGSEIWRDIDFAHEAPAFLPWHRLFLLRWEQEIQKLTGDENFTIPYWDWRDAEKCDICTDEYMGGQHPTNPNLLSPASFFSSWQIVCSRLEEYNSHQSLCNGTPEGPLRRNPGNHDKSRTPRLPSSADVEFCLSLTQYESGSMDKAANFSFRNTLEGFASPLTGIADASQSSMHNALHIYMNGTMSQVQGSANDPIFLLHHAFVDSIFEQWLRRHRPLQEVYPEANAPIGHNRESYMVPFIPLYRNGDFFISSKDLGYDYSYLQDSDPDSFQDYIKSYLEQASRIWSWLLGAAMVGAVLTALLAGLVSLLCRHKRKQLPEEKQPLLMEKEDYHSLYQSHL

Gene
TYR
Protein
Tyrosinase
Organism
Coturnix japonica
Length
273 amino acids
Function
This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine. In addition to hydroxylating tyrosine to DOPA (3,4-dihydroxyphenylalanine), also catalyzes the oxidation of DOPA to DOPA-quinone, and possibly the oxidation of DHI (5,6-dihydroxyindole) to indole-5,6 quinone.
Similarity
Belongs to the tyrosinase family.
Mass
31.5 kDa
Fragment
single
Sequence
MLLFTMGLLLAILQPSTGQFPRVCANTQSLLRKECCPPWEGDGSPCGERSNRGTCQRILLSQAPLGPQFPFSGVDDREDWPSVFYNRTCRCRGNFMGFNCGECKFGFSGQNCTERRLRTRRNIFQLTIREKDKFLAYLNLAKNIPSKDYVIATGTYAQMNNGSNPMFRNINVYDLFVWMHYYASRDTLLGGSNVWRDIDFAHEAPGFLPWHRAFLLLWEREIQKITGDENFTIPYWDWRDAEDCVICTDEYMGGQHPTNPNLLSPASFFSSWQ

Gene
TYR
Protein
Tyrosinase
Organism
Pelodiscus sinensis
Length
273 amino acids
Function
This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds.
Similarity
Belongs to the tyrosinase family.
Mass
31.136 kDa
Fragment
single
Sequence
MCLLALGFLLGILQPASGQFPRACASSESLLRKECCPLWAGDGSPCGELSGRGSCQEILLSRAPLGPQFPFTGVDDREDWPAVFYNRTCQCNSNFMGFNCGECRFGFSGPNCAERRMRMRRSIFQLSTREKNKFLAYLNLAKHTPSQDYVIATGTYAQMNNGLTPMFRNISVYDLFVWMHYYVSRDTLLGDASVWRDIDFAHEAPGFLPWHRLFLVLWEHEIQKITGDENFTIPYWDWRDAEGCDVCTDELMGDRHPTNPQLLSPASFFSSWQ

Gene
TYR
Protein
Tyrosinase
Organism
Felis catus
Length
80 amino acids
Function
This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine. In addition to hydroxylating tyrosine to DOPA (3,4-dihydroxyphenylalanine), also catalyzes the oxidation of DOPA to DOPA-quinone, and possibly the oxidation of DHI (5,6-dihydroxyindole) to indole-5,6 quinone.
Similarity
Belongs to the tyrosinase family.
Mass
8.694 kDa
Fragment
single
Sequence
LEEYNSRQALCDGTPEGPLLRNPGNHDKARTPRLPSSADVEFCLSLTQYESDSMDKAANFSFRNTLEGFASPLTGIADAS