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TWNK

Gene
Twnk
Protein
Twinkle protein, mitochondrial
Organism
Mus musculus
Length
685 amino acids
Function
Involved in mitochondrial DNA (mtDNA) metabolism. Could function as an adenine nucleotide-dependent DNA helicase. Function infered to be critical for lifetime maintenance of mtDNA integrity. May be a key regulator of mtDNA copy number in mammals.
Mass
76.993 kDa
Sequence
MWLLLRRAYPLRILLPLRGEWVGRRGLPRSLAPGPPRRRYRKEALPALEMPVSPVTTTEIRQYLRAHGIPFQDGHSCLRAPSPFVVSSDIKNEKKDAPTSFCLFIDKTTGHFLCMTSLAEGSWEDLQASVEGRGDGAKEGVLLREGPEAEVREEVLRIWNRAIPLWELPDPEEAQLARVMFGLTKVTDDTLRRFSVRYLRSARSLVFPWFTPGSSGLRGLKLLGAEGQENGVQYVETTIPRPGVYHNLFGLPLISRRDTEVVVTSRELDSLALSQSTGLPTLSLPRGTVCLPPALLPYLEQFRRIVFWLGDDLRSWEAAKLFARKLNPKRCSLVRPGNQQPRPLEALNQGLSLPRILRTALPAWHKSIVSFRQLREEVLGELSNVEQAAGVRWSRFPDLNRLLKGHRKGELTVFTGPTGSGKTTFISEYALDLCTQGVNTLWGSFEISNVRLARVMLTQFAVTRLEEQLDKYEEWADRFEDLPLYFMTFHGQQSIRSVIDTMQHAVYVYDVCHVVIDNLQFMMGHEQLSSDRIAAQDYIVGAFRKFATDNSCHVTLVIHPRKEDDDKELQTASIFGSAKASQEADNVLILQDRKLVTGPGKRYLQVSKNRFDGDVGVFPLEFNKNSLTFSIPPKSKARLKKIKDDNGLVAKKSSSGKKGAAHQNPEICLGQDPSPAQPDTSKSSG

Gene
TWNK
Protein
Twinkle protein, mitochondrial
Organism
Homo sapiens
Length
684 amino acids
Function
Involved in mitochondrial DNA (mtDNA) metabolism. Could function as an adenine nucleotide-dependent DNA helicase. Function inferred to be critical for lifetime maintenance of mtDNA integrity. In vitro, forms in combination with POLG, a processive replication machinery, which can use double-stranded DNA (dsDNA) as template to synthesize single-stranded DNA (ssDNA) molecules. May be a key regulator of mtDNA copy number in mammals.
Mass
77.154 kDa
Sequence
MWVLLRSGYPLRILLPLRGEWMGRRGLPRNLAPGPPRRRYRKETLQALDMPVLPVTATEIRQYLRGHGIPFQDGHSCLRALSPFAESSQLKGQTGVTTSFSLFIDKTTGHFLCMTSLAEGSWEDFQASVEGRGDGAREGFLLSKAPEFEDSEEVRRIWNRAIPLWELPDQEEVQLADTMFGLTKVTDDTLKRFSVRYLRPARSLVFPWFSPGGSGLRGLKLLEAKCQGDGVSYEETTIPRPSAYHNLFGLPLISRRDAEVVLTSRELDSLALNQSTGLPTLTLPRGTTCLPPALLPYLEQFRRIVFWLGDDLRSWEAAKLFARKLNPKRCFLVRPGDQQPRPLEALNGGFNLSRILRTALPAWHKSIVSFRQLREEVLGELSNVEQAAGLRWSRFPDLNRILKGHRKGELTVFTGPTGSGKTTFISEYALDLCSQGVNTLWGSFEISNVRLARVMLTQFAEGRLEDQLDKYDHWADRFEDLPLYFMTFHGQQSIRTVIDTMQHAVYVYDICHVIIDNLQFMMGHEQLSTDRIAAQDYIIGVFRKFATDNNCHVTLVIHPRKEDDDKELQTASIFGSAKASQEADNVLILQDRKLVTGPGKRYLQVSKNRFDGDVGVFPLEFNKNSLTFSIPPKNKARLKKIKDDTGPVAKKPSSGKKGATTQNSEICSGQAPTPDQPDTSKRSK

Gene
TWNK
Protein
Twinkle protein, mitochondrial
Organism
Gallus gallus
Length
669 amino acids
Function
Involved in mitochondrial DNA (mtDNA) metabolism. Could function as an adenine nucleotide-dependent DNA helicase. Function inferred to be critical for lifetime maintenance of mtDNA integrity (By similarity).
Mass
73.995 kDa
Sequence
MAAVPLRPCRASGRFLPLLRGGARSRGASPWAAGPGRVAQRRYKKDVLPEPGGAAPAVSVTEIRRYLRAQGIPFQDGYSCLHAPSLFGPELPPAAGPPFTLFIDKTTGSFLCTATLAEGGWQDLQAAVELRHRGVPAPGPDEGEREEEEEAEARRAREDARRIWERALPLGELLDEEETRATKAAFGIAPLADGTLKRFGVRYLRAAKALVFPWFAPRDAALRGLKLLVAEQRGDAVSYTEETLPRFDAYRNLFGLPLIGRRDAEVVLTGSELDALALHQATGVPCLALPRGATILPPALLPYLEQFRRVTLWLGDDLRSWEASKLFARKLNPKRCSLVQPGDLQPRPLEALNRGLNLTKILRAALPAGHKAIVSFRQLREEVFGELANSEQVAGVKWARFPELNKLLKGHRRGELTVFTGPTGSGKTTFISEYALDLCTQGVCTLWGSFEINNIRLAKIMLTQFATRRLEDQLELYDEWADRFEDLPLYFMTFHGQQNIKTVLDTMQHAVYMYDITHVVVDNLQFMMGHEQLSADRLAAQDFIVGAFRKFATDNTCHITLVIHPRKEDDEKELQTASIFGSAKASQEADNVLILQDRKLTTGPGKRYLQVSKNRFDGDVGVFPLEFSKASLTFSSYGKSKAKLKKVKEEKGPSPKKGPSGGVGGSSKP