Protein
N(1)-aminopropylagmatine ureohydrolase
Organism
Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
Function
Involved in the biosynthesis of polyamines which are thought to support the growth of thermophilic microorganisms under high-temperature conditions. It seems that long-chain and branched-chain of polyamines effectively stabilize DNA and RNA, respectively. Catalyzes the decarboxylation of N1-(3-aminopropyl)agmatine to yield spermidine and urea. Does not act on agmatine.
Similarity
Belongs to the arginase family.
Sequence
MRLVFGEKDAPYEEARVVVLPVPYDLSLSFLPGARRGPEAILLASRELEPFLLELGAAPEEVGIHAAEPVPWVAGMAEESHRLIREEALKHLRAGKWLVALGGDHSVTHPLVQAHREALGEFSLLHVDAHADLYPEWQGSVYSHASPFYRLLTEGFPLVQVGIRAMDRDSLRLARKRGVALFPAHRIHREGLPLDEILEALGKRVYISLDFDALDPSLMPSVGTPLPGGLSYRQVVDLLEAVFREKEVVGMDFVELSPNGQFHAEMTAAQLVYHAIGLKGLQAGWLSREVDHI