TTLL3A

Tubulin glycylase 3A

992 amino acids

Polylycylase which modifies alpha- and beta-tubulin, generating side chains of glycine on the gamma-carboxyl groups of specific glutamate residues within the C-terminal tail of alpha- and beta-tubulin. Involved both in the side-chain initiation and elongation steps of the polyglycylation reaction by adding a single glycine chain to generate monoglycine side chains and by elongating monoglycine side chains to polyglycine side chains.

112.256 kDa

MQTRPSSEPHRSRDQVTDGDRNRDQPQKCASATLAKKPVTPPAAPPPTPSNRVVAPLTVPVIQLTPAQSDSPVKLARPATPKETAISVPDHSNKENQPARTPPPSKSCPLGAPTNYVARRTWITTERMNELRRKAQEAAKQNKIFTIRGCFNSVRNALLMRGWVEKLDVHRKVMPAGQMTYEDLTQRLPKRKAGETRRQYVQKCERNIMSRFLEHMPVDFLWTNRKEKCDYIDQAKNPGMTINKFHRAPFTSKEGLCSQLRDFHWFFEEGTAEMYFPRCYNVWSPEELGEFIENFKLTACVAFLRAMLCKYHKQGSDAVFSCSGKIPYSAIDFAYKRLVEYIDSCQHNDIDFEDPPKIWEHDWDAFLFQHQQLVNEDGRIQHDGGQRLEPMVKSCLSLVDKMKVHWPQYSLDGYQNMWIVKPANKCRGRGIILMDNLKKILGVVNLSIASKSRYVVQKYIERPLILFQTKFDIRQWFLITNTQPLVVWFYRESYLRFSSQEYSLSNHHESVHLTNYAIQKKYTNGKRDKRLPSENMWDCYSFQAYLRQIGKYNMWLERIFPGMRKAIVGCMLASQENMDRRPNTFELFGADFMICENFYPWLIEINSSPDLGATTSVTARMCPQCLEDVVKVVIDRRTDPKAELGNFELAYRQVVPPTPAYMGLNLFVKGKQVLQKANHGGGHGHYYYQQQRKERSLATSSVYRQRSAIIHPATSISRIHRAMPTFNATEYMEKYMVEPLSSSRSSLCSQLPQKSPSAAPALTATPSGATSSYILKQAGRSITQLLSATHKRNTGGSLSGEQVQSTALPPKRQRSCGPRLSSTNPVESTEKKFKILIKNYSSNGNENMQDARPEVANSATATAISERKWRSLRNIAATAGGSSNLAARSKGPPLIAPPSLPTRRLTRTKSEIDSTGMHAIGRTFGRKSNGPRLPISISVQALHRGEPIVAALKQATSELQLSQAQMMSPRTALANKLNGSTLMVPASALPVG

TTLL3A

Tubulin glycylase 3A

875 amino acids

Monoglycylase which modifies alpha- and beta-tubulin, generating side chains of glycine on the gamma-carboxyl groups of specific glutamate residues within the C-terminal tail of alpha- and beta-tubulin. Involved in the side-chain initiation step of the glycylation reaction by adding a single glycine chain to generate monoglycine side chains. Not involved in elongation step of the polyglycylation reaction.

103.066 kDa

MFQQNQQSQNQQAQNLMHIQLNGNTQLGLGALQTINVKPIKLQSRAQSLNPNLRISERNKQTTQTSSNRQNISNKSPNNLQTSKSGGLQTQNANQKLSSSSAPKKISGNFSSRVIYRAKTKNEDEIIKKQSSQTSISTNGQEKKGEIIRFATESQINNENSTPNSKIQLPPIQEKNSYKFYINSQSSNNQVSQDQSPPLQGLQAFNINKNKENQFTKKRHFDFLERTKVKNQSEETDLLKMHRYFRCKVSNLITGSGKKQYYLQYLKDMKDLMTKVKQYERVAKQNLFINDVMNKLKKIVATRAKYKYKEKIDFTRSIIMRTLGYESRQIIQQLKENMALEEQEYEDLEDDADREYEELKKKQEQQALDKNQKKELISSEIIANWKKMRGYQPNQKVFICIGQYTDLKNYLKEQGWIENPNPESLVFDLKWVTKKKDVDKDLLLDQQITNHFQKNHNLTSKNGIALNLRNLIWYDSVDIDTFYPRCFDLSDVQEFEDFIEEFKFTQAESILKQYVENKLVIDQKAKQYEKYLRLKILLACVALKRRTFSIEKKISLISVNTLPIISPEEWSVLNRQDNNYLFLEQNPDVYHRLSQIITREMDSEESNAVDLSKLAQKYLEASKEYDPQYDLNEKNLWIVKPAGLSRGRGIRAFDQLEPLLNYIMGKDVMWVAQKYMENPLTIHKKKFDIRQWVLVTEWNPLTIYFYDTCYIRICFDEYDPSDLQNKFAHLANNCISKHADNFEEKVNDTMMYLEDFVEYIKKIEGKDMFYSKIQKEMMNIAINSIKSCKDSIEPRRNSLELYGYDFMVDQNYNTWLLEINSSPSMEYSTPVTTKLVKMGLEDTAKVIHHHFVEGEKRFNKNIEYGLWKNIYREQK