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TTI1

Gene
tti1
Protein
TEL2-interacting protein 1
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Length
1098 amino acids
Function
Component of the TORC1 and TORC2 complexes required for the regulation of the cellular respons to changes in available nutrients.
Similarity
Belongs to the tti1 family.
Mass
124.765 kDa
Sequence
MSHIQSIFAQIRDPFRKLSFYSLPLSSETSSVDSNGLKNSLKDAYFGLEKALTNTDADLPLNLCDYIFFPIVPVLKSWYRVPSTGVEYAIQCVNLLYKHGWREAHNEMLTMQLLLMLLNIADGWKSPSETVEQDFRVREITFETLENVITDFKPNFHDKRQYLLFARALSSALDIIPNKNSSRRLQFASLCCVQKLICPKQYRLPTEFLTTFLPGIVSGLTKGLAPNGTCQYFKNVCISLNILGDTVVKAISDDNTKDLPDEKDASSNSHFFGPTKRTKSWKRATCQQLSNAVKAILHLRSSQNLHVQDALFDFCFILFRDCLDSLKDCRIHLLESMLKLINKKENPKLRDYGMNKLVSLIESFNNITMESVLTECLNDWSTTWSSVSTFASEDNKLEELNRLKSLLSISSHLPKTLQLMEPLLDGILSQLVPKSSGIDSNSQKLLTSSTSNEYIHGEFFGGNEMERTTQEIVTSFAKAPNVKYVMQSLLSKATSATNENSVRAFWAFMVLLKSDVETVDSLEMYIDSLEQYSFEVLQQLSQLNVFTKASLEDKQKKEKYNLLCVRSCIAIDSISWISSLQGVKFRSKLMAYFYPLLEHLAFASPYVSSFAEACIQAIATNCNYSTPAELLRENIDYVVNSVALKLNTLDVSPQLPIVMAYVIKNDDGGCIRYIGDVVDAIFGILDAYHGYARLTEGLLGILYAIIKQESINGEEKKLIVGVEEDAMNEDKNKPCKKIREFVQLLLENPNYPLPKDDHELEDMIHDEQQETKSGHEQFREHAMKEKEKKGKENENMGETTVDHENINSNVMDEQGEKQKDDVVDMVRKITEKAQLFLSHEQITIRVEMLKLLSYGSNVLAKEPNTFYPAINTFWPLVVIQLDTDNELLVECALETIYQVCALADDFMTSRIRQDLLPRLETLCQRWHLFNVARTYSSEHRLQRAMLKVTSACVANKLSIVVYLKLMGITAPIIRAITHMSQKYAGDESLVEETWNAFSKQNPDAVYYEREVRGSQMIDTFSTELLIPGKQRVQRTYRRTHEVLEPVGAKTSETVFNDLLGQQGSGKTETQEEPLPSLDNLLHLNQPKKGAKKPLISII

Gene
TTI1
Protein
TELO2-interacting protein 1 homolog
Organism
Homo sapiens
Length
1089 amino acids
Function
Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals.
Similarity
Belongs to the tti1 family.
Mass
122.069 kDa
Sequence
MAVFDTPEEAFGVLRPVCVQLTKTQTVENVEHLQTRLQAVSDSALQELQQYILFPLRFTLKTPGPKRERLIQSVVECLTFVLSSTCVKEQELLQELFSELSACLYSPSSQKPAAVSEELKLAVIQGLSTLMHSAYGDIILTFYEPSILPRLGFAVSLLLGLAEQEKSKQIKIAALKCLQVLLLQCDCQDHPRSLDELEQKQLGDLFASFLPGISTALTRLITGDFKQGHSIVVSSLKIFYKTVSFIMADEQLKRISKVQAKPAVEHRVAELMVYREADWVKKTGDKLTILIKKIIECVSVHPHWKVRLELVELVEDLLLKCSQSLVECAGPLLKALVGLVNDESPEIQAQCNKVLRHFADQKVVVGNKALADILSESLHSLATSLPRLMNSQDDQGKFSTLSLLLGYLKLLGPKINFVLNSVAHLQRLSKALIQVLELDVADIKIVEERRWNSDDLNASPKTSATQPWNRIQRRYFRFFTDERIFMLLRQVCQLLGYYGNLYLLVDHFMELYHQSVVYRKQAAMILNELVTGAAGLEVEDLHEKHIKTNPEELREIVTSILEEYTSQENWYLVTCLETEEMGEELMMEHPGLQAITSGEHTCQVTSFLAFSKPSPTICSMNSNIWQICIQLEGIGQFAYALGKDFCLLLMSALYPVLEKAGDQTLLISQVATSTMMDVCRACGYDSLQHLINQNSDYLVNGISLNLRHLALHPHTPKVLEVMLRNSDANLLPLVADVVQDVLATLDQFYDKRAASFVSVLHALMAALAQWFPDTGNLGHLQEQSLGEEGSHLNQRPAALEKSTTTAEDIEQFLLNYLKEKDVADGNVSDFDNEEEEQSVPPKVDENDTRPDVEPPLPLQIQIAMDVMERCIHLLSDKNLQIRLKVLDVLDLCVVVLQSHKNQLLPLAHQAWPSLVHRLTRDAPLAVLRAFKVLRTLGSKCGDFLRSRFCKDVLPKLAGSLVTQAPISARAGPVYSHTLAFKLQLAVLQGLGPLCERLDLGEGDLNKVADACLIYLSVKQPVKLQEAARSVFLHLMKVDPDSTWFLLNELYCPVQFTPPHPSLHPVQLHGASGQQNPYTTNVLQLLKELQ

Gene
Tti1
Protein
TELO2-interacting protein 1 homolog
Organism
Mus musculus
Length
1085 amino acids
Function
Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals (By similarity).
Similarity
Belongs to the tti1 family.
Mass
120.814 kDa
Sequence
MAVFDTPEEAFGVLRPVCVQLTKTQTVENVEHLQTQLQAISDTALQELQQYILFPLRFALKTPGPKRERLVQSVVECLTFVLSSTCVREQELLQELFSELSACLYSPSSQKPAALSEELKLAVIQGLSTLMHSAYRDIILTFYEPSILPRLGFAVSLLLGLAEQEKSKQIKIAALQCLQVLLLQCDCQDHPRPLDELEQQQLGDLLASFLPGISTALTRIITGDFKQGHSIVVSSLKVFYKTVGFIMADEQLTRIPKAQAKPVVEHRVAALMIHREADWVKSTGDKLAIFIKKIIDCVSVHPHWKVRLELVEFVEILLLKCTQSLVESTGPLLKVLVGLVNDESPEVQARCSTVLRRLADQKVVVGSRALADILSESLHSLATSLPRLMNTQDDQGKFSTLSLLLGYLKLLGPKVHVILNSVAHVQRLSRALIQVLELEVTDVKMVEERRWNSDNLSASAEVSAARPWSRVQRRYFRCFTDERVFLLLRKICQLLGYYGDLYLLVDHFMELYHTSVVYRKQAAMILNELVVGAAGLDVEDIHNKCPSMGPEELREIVKSILEEYTSQENWYLITCFEAEEGEEVMMKQQGFQAVTSGVHTCQVVSFPALSKPSPTICSMNSNIWQICIQLEGIGQFAYALGKDFRLLLMSALYPILEKAGDPTLLISQVATSTMVDICHACGYNSVQHLINQNSDYLVNGISLNLRHLALHPHAPKVLEAMLRNADASLLPLVADVVQDVLATLDQFYDKRAASFVSVLHALLAALAHWFPDSGSTGQLQQRSLEEEGRQLPAAGEASTTAEDIEQFVLSYLQEKDVAEGNVSDLEAEEEVQSAPPKVDENDTLPDVEPPLPTHIQIAKDVMERCIHLSADKNLKIRLKVLDVLGLCVEVLQTHKNQLLPLAHRAWPSLVHRLTSDDPLAVLRAFKVLQTLGSRCGDFLRSRFCKDVLPKLTSSLITQAPISARAGPVYSHTLAFKLQLAVLQGLGPLCENLDLGEGDLNKVADACVIYLSTKQPVKLQEAARSVFLHLMRVDPDSTWLLLHELYCPVQQFTAPHPSLHPVQLQGATQPQNPYATNVCHLLLQLQ

Gene
TTI1
Protein
TEL2-interacting protein 1
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Length
1038 amino acids
Function
Component of the ASTRA complex involved in chromatin remodeling.
Similarity
Belongs to the tti1 family.
Mass
118.889 kDa
Sequence
MNSDTNAFKDIRISCVELSRIAFLPTESFDPNSLTLLACLKKVEEKLSAYEDDSLSPKFADYVFVPIASLLKQPALGESQTEYVLLIIFHLLRTCWSSNGKFSEQLGQQLFPLITFLVSSDKDNQKLITRSDEFKYAGCLVLHQFFKSVRSQRYHKEFFSNSKPNLLPALGHSVTILLKILEQSPQNNELQFKALASLEVLFQDIISDGEMLSFILPGNVSVFAKILTKPGRQIHYKVCVRTLEVLAKLLVLVYDDFSLDIKVNKLTDIRELSDTKLKHEINQSFMFNGPIVLLRTDGKTHRDTSWLTATSGQINIALEAFIPKLLKRNNESIDEALATFVSILLTRCENSLNNCEKVLVSTLVHLERDPMSKLPSHLVKLKEVVNEDLHKLSDIIRFENADRLSSLSFAITILEKNNERDTMINEVVRCLFESLNESIEPPSLINHKERIIEQSSQLTTTVNFENLESTNALIALPRLSEDMSLKLKKFTYHMGSLLLERHILNDVVTELISEQVDSPRTQKIVALWLSTNFIKAMEKQPKEEEVYLQFESDANYSSSMVEEVCLIVLEFCNELSQDISMEIEGKGIKKSDEFAVCTVLFSIETICAVMREEFQPELIDYIYTVVDALASPSEAIRYVSQSCALRIADTLYHGSIPNMILSNVDYLVESISSRLNSGMTERVSQILMVICQLAGYETIENFKDVIETIFKLLDYYHGYSDLCLQFFQLFKIIILEMKKKYINDDEMILKIANQHISQSTFSPWGMTDFQQVLNILDKETQVKDDITDENDVDFLKDDNEPSNFQEYFDSKLREPDSDDDEEEREEEVEGSSKEYTDQWTSPIPSDSYKILLQILGYGERLLTHPSKRLRVQILIVMRLIFPLLSTQHNLLIREVASTWDSIIQCVLCSDYSIVQPACSCVEQMIKYSGDFVAKRFIELWQKLCQDSFILKELRIDPTVHNHEKKSISKHVKFPPVTENALVSMVHMVLEGVKITEYLISEAVLEQIIYCCIQVVPVEKISSMSLIVGDIVWKIRNIN