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TRS1

Gene
TRS1
Protein
Protein HHLF1
Organism
Human cytomegalovirus (strain AD169)
Length
788 amino acids
Function
Inhibits the establishment of the antiviral state in the infected cell. Prevents the phosphorylation of the host eukaryotic translation initiation factor eIF-2alpha/EIF2S1 and thus the shutoff of viral and cellular protein synthesis by directly interacting with EIF2AK2/PKR. Also inhibits host autophagy by interacting with host Beclin-1/BECN1.
Similarity
Belongs to the herpesviridae US22 family.
Mass
83.982 kDa
Sequence
MAQRNGMSPRPPPLGRGRGAGGPSGVGSSPPSSCVPMGAPSTAGTGASAAATTTPGHGVHRVEPRGPPGAPPSSGNNSNFWHGPERLLLSQIPVERQALTELEYQAMGAVWRAAFLANSTGRAMRKWSQRDAGTLLPLGRPYGFYARVTPRSQMNGVGATDLRQLSPRDAWIVLVATVVHEVDPAADPTLGDKAGHPEGLCAQDGLYLALGAGFRVFVYDLANNTLILAARDADEWFRHGAGEVVRLYRCNRLGVGTPRATLLPQPALRQTLLRAEEATALGRELRRRWAGTTVALQTPGRRLQPMVLLGAWQELAQYEPFASAPHPASLLTAVRRHLNQRLCCGWLALGAVLPARWLGCAAGPATGTAAGTTSPPAASGTETEAAGGDAPCAIAGAVGSAVPVPPQPYGAAGGGAICVPNADAHAVVGADAAAAAAPTVMVGSTAMAGPAASGTVPRAMLVVLLDELGAVFGYCPLDGHVYPLAAELSHFLRAGVLGALALGRESAPAAEAARRLLPELDREQWERPRWDALHLHPRAALWAREPHGQLAFLLRPGRGEAEVLTLATKHPAICANVEDYLQDARRRADAQALGLDLATVVMEAGGQMIHKKTKKPKGKEDESLMKGKHSRYTRPTEPPLTPQASLGRALRRDDEDWKPSRLPGEDSWYDLDETFWVLGSNRKNDVYQRRWKKTVLRCGLEIDRPMPTVPKGCRPQTFTHEGIQLMGGATQEPLDTGLYAPSHVTSAFVPSVYMPPTVPYPDPAARLCRDMRRVTFSNIATHYHYNAQ
Protein
Protein HHLF1: TRS1

Gene
TRS1
Protein
Protein TRS1
Organism
Human cytomegalovirus (strain Merlin)
Length
788 amino acids
Function
Inhibits the establishment of the antiviral state in the infected cell. Prevents the phosphorylation of the host eukaryotic translation initiation factor eIF-2alpha/EIF2S1 and thus the shutoff of viral and cellular protein synthesis by directly interacting with EIF2AK2/PKR. Also inhibits host autophagy by interacting with host Beclin-1/BECN1 (By similarity).
Similarity
Belongs to the herpesviridae US22 family.
Mass
83.959 kDa
Sequence
MAQRNGMSPRPPPLGRGRGAGGPSGVGSSPPSSCVPMGATSTAGTGASAAPTATPGHGVHRVEPRGPPGAPPSSGNNSNFWHGPERLLLSQIPVERQALTELEYQAMGAVWRAAFLANSTGRAMRKWSQRDAGTLLPLGRPYGFYARVTPRSQMNGVGATDLRQLSPRDAWIVLVATVVHEVDPAADPTVGDKAGHPEGLCAQDGLYLALGAGFRVFVYDLANNTLILAARDADEWFRHGAGEVVRLYRCNRLGVGTPRATLLPQPALRQTLLRAEEATALGRELRRRWAGTTVALQTPGRRLQPMVLLGAWQELAQYEPFASAPHPASLLTAVRRHLNQRLCCGWLALGAVLPARWLGCAAGPATGTTSPPAASGTETEAAGGDAPCAMAGAVGSAVTIPPQPYGGAGGSAICVPNADAHAVVGADATAAAAAAAAAPTVMVGPTAMAGPAASGTVPRAMLVVVLDELGAVFGYCPLDGHVYPLAAELSHFLRAGVLGALALGRESAPAAEAARRLLPELDREQWERPRWDALHLHPRAALWAREPHGQLAFLLRPGRGEAEVLTLATKHPVICANVEDYLQDARRRADAQALGLDLATVVMEAGGQMIHKKTKKPKGKEDESVMKGKHSRYTRPTEPPLTPQASLGRALRRDDEDWKPSRVPGEDSWYDLDETFWVLGSNRKNDVYQRRWKKTVLRCGLEIDRPMPTVPKGCRPQTFTHEGIQLMGGATQEPLDTGLYAPSHVTSAFVPSVYMPPTVPYPDPAARLCRDMRRVTFSNVATHYHYNA
Protein
Protein TRS1: TRS1