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TRMU

Gene
trmu
Protein
Mitochondrial tRNA-specific 2-thiouridylase 1
Organism
Dictyostelium discoideum
Length
451 amino acids
Function
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2-thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base.
Similarity
Belongs to the MnmA/TRMU family.
Mass
51.498 kDa
Sequence
MINNINRIKKTYNTFLNVNKLRYSTSIISSNILENDNNNIDDFEQVLKSTKVRMPTSALLLPKKPKVCIGMSGGVDSTITAKLLKLQGFDVTGVFIKSWDEVEDTGRCQGERDWKDALEASNFLDIPMYKADFVKDYWNRVFVDFLKDYKNGLTPNPDVWCNREIKFDLFFDFAKENFGVDYIATGHYSNLYYGEENVGDNNNNNLQLHRAIDKNKDQTFFLCMTKGERLKQAIFPIGGFTKENIVSFAKTIPNFSKITSKKSSRGICFIGKRPLPDFLSQYMTLKPGDFFDISTNSFIKGKKHKGSVCYTMGQKANIDSLSERYFIVRSDIERNIVYVCPESQFDQFSLYYEFNTHSFNWINEIPTEVKSEQGFKGRGICRHRGDVVNLTIKDTGKTSPIDGSVIYSVNLDQPLRSVASGQILCLFDRNTDRCFGGGVINSSPLYNPTQF

Gene
Trmu
Protein
Mitochondrial tRNA-specific 2-thiouridylase 1
Organism
Rattus norvegicus
Length
441 amino acids
Function
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2-thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base.
Similarity
Belongs to the MnmA/TRMU family.
Mass
49.724 kDa
Sequence
MSALRHVVCALSGGVDSAVAALLLRRRGYQVTGVFMKNWDSLDEQGICAADKDCEDAYKVCQILDIPFHQVSYVKEYWNDVFSDFLNEYEKGRTPNPDISCNKHIKFSCFHHYAVDNLGADAVATGHYARTSLEDEEVFEQKHTKRPDGLFRNRFEVRNPVKLLQAADSFKDQTFFLSQVSQDALRRTIFPLGELTKDFVKKIAAENRLHHVLQKKESMGICFIGKRNLEHFLLQVSVSDVSGGLLWAGAPVVMKPVFQYLQPRPGKFISIEDNRVLGTHKGWFLYTLGQRAKISGLSEPWYVVEKDGTKGDVLVAPRVDHPALYRDLLRTNRVHWIAEEPPAALVRDKMMECHFRFRHQMALVPCVLTLNQDGTVWVTAVKAVRGLALGQFAVFYKGEECLGSGKILRLGPSAYTLQKGKNRTRVAPEVSSDSPGLHPTS

Gene
TRMU
Protein
Mitochondrial tRNA-specific 2-thiouridylase 1
Organism
Gallus gallus
Length
424 amino acids
Function
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2-thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base.
Similarity
Belongs to the MnmA/TRMU family.
Mass
48.37 kDa
Sequence
MLAAGRRVACAVSGGVDSAVAALLLRRRGYQVTGVFMKNWDPLDEQGACSVDRDCEDAYRVCQKLDIPFHQVSYVKEYWNEVFSDLLKEYELGRTPNPDIVCNKHIKFNHFLHYAMDNLGADAIATGHYARTSLEDEEVFQQKHTKRPRELFRNRFEVRNTVKLLQGADLFKDQTFFLSQISQDALRKTIFPLGDLTKSFVRKIASEHGLHHVLKKKEACTTFPFQSMGVCFIGERNFEKFLLEYLEPQPGNFVSIEDKKVMGTHKGWFLYTIGQRARLAGLQGAWFVVDKDVSTGDIFVAPSTDHPALFRDLLRTNRVHWIAEEPPAELVRDKMMECHFRFRHQMALVPCVLTLNQDGSVWVTLVKPARALTPGQFAVFYKGDECLGSGKILRLGPSVFTMQQGRNREEGTKKEDIDKVEPAT

Gene
TRMU
Protein
Mitochondrial tRNA-specific 2-thiouridylase 1
Organism
Pongo abelii
Length
422 amino acids
Function
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2-thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base.
Similarity
Belongs to the MnmA/TRMU family.
Mass
47.764 kDa
Sequence
MQAVRHVVCALSGGVDSAVAALLLRRRGYQVTGVFMKNWDSLDEHGVCTADKDCEDAYRVCQILDIPFHQVSYVKEYWNDVFSDFLNEYEKGRTPNPDIVCNKHIKFSCFFHYAVDNLGADAIATGHYARTSLEDEEVFEQKHIKKPEGLFRNRFEVRNAVKLLQAADSFKGQTFFLSQVFSQDALRRTIFPLGGLTKEFVKKIAAENRLHHVLQKKESMGMCFIGKRNFEHFLLQYLQPRPGHFISIEDNKVLGTHKGWFLYTLGQRANIGGLREPWYVVEKDSVKGDVFVAPRTDHPALYRDLLRTSRVHWIAEEPPAVLVRDKMMECHFRFRHQMALVPCVLTLNQDGTVWVTAVQAVRALATGQFAVFYKGDECLGSGKILRLGPSAYTLQKGQCGAEVATESPTDSPEDGPGLSPLL

Gene
TRMU
Protein
Mitochondrial tRNA-specific 2-thiouridylase 1
Organism
Homo sapiens
Length
421 amino acids
Function
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2-thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base.
Similarity
Belongs to the MnmA/TRMU family.
Mass
47.745 kDa
Sequence
MQALRHVVCALSGGVDSAVAALLLRRRGYQVTGVFMKNWDSLDEHGVCTADKDCEDAYRVCQILDIPFHQVSYVKEYWNDVFSDFLNEYEKGRTPNPDIVCNKHIKFSCFFHYAVDNLGADAIATGHYARTSLEDEEVFEQKHVKKPEGLFRNRFEVRNAVKLLQAADSFKDQTFFLSQVSQDALRRTIFPLGGLTKEFVKKIAAENRLHHVLQKKESMGMCFIGKRNFEHFLLQYLQPRPGHFISIEDNKVLGTHKGWFLYTLGQRANIGGLREPWYVVEKDSVKGDVFVAPRTDHPALYRDLLRTSRVHWIAEEPPAALVRDKMMECHFRFRHQMALVPCVLTLNQDGTVWVTAVQAVRALATGQFAVFYKGDECLGSGKILRLGPSAYTLQKGQRRAGMATESPSDSPEDGPGLSPLL

Gene
Trmu
Protein
Mitochondrial tRNA-specific 2-thiouridylase 1
Organism
Mus musculus
Length
417 amino acids
Function
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2-thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base.
Similarity
Belongs to the MnmA/TRMU family.
Mass
47.24 kDa
Sequence
MSALRHVVCALSGGVDSAVAALLLRRRGYQVTGVFMKNWDSLDEQGVCAADKDCEDAYKVCQILDIPFHQVSYVKEYWNDVFSDFLNEYEKGRTPNPDINCNKHIKFSCFYHYAVDNLGADAVATGHYARTSLEDEEVFEQKHTKKPDGLFRNRFEVRNPVKLLQAADSFKDQTFFLSQVSQDALRRTIFPLGELTKDFVKKIAAENSLHHVLQKRESMGICFIGKRNLEHFLLQYLQPRPGKFVSIEDNTVLGTHKGWFLYTLGQRAKISGLREPWYVVEKDGTKGDVLVAPRVDHPALYRDLLRTNRVHWIAEEPPAALVRDKMMECHFRFRHQMALVPCVLTLNQDGTVWVTAVKAVRGLALGQFAVFYKGEECLGSGKILRLGPSAYTLQKGKNRTRVAPEASSDSPGLHPTS

Gene
trmu
Protein
Mitochondrial tRNA-specific 2-thiouridylase 1
Organism
Danio rerio
Length
416 amino acids
Function
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2-thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base.
Similarity
Belongs to the MnmA/TRMU family.
Mass
47.564 kDa
Sequence
MGVLRHVVCAMSGGVDSSVSALLLKRMGYHVTGVFMKNWDSQEEKGLCSSDRDCEDAYKVCKMLDIPFHEVSYVKEYWHEVFSNLLWEYERGRTPNPDIICNKHIKFKHFYQYAVNTLGADAMATGHYARTSQEDEEVFQQKLTEAPKSLFRDRFEIRKPVRLYQGADLLKDQTFFLSQISQDALRHTLFPLAGLTKGYVKKIAAEAGFQHVLKKKESMGICFIGKRDFENFILEYLEPRPGNFVSIEDGQIMGKHKGWFTLTLGQRARIGGRADAWFVVDKDVTTADVFVCPSTFHPALFRDTLQTDRFHWIAEEPPAELVHTQMMDCHFCFNNRMPLTPCTVTLNLDGSVWVMVKEPMRGMATGQFAVLYKGHECLGSGKIIRLGPTKFALQKDQSNTNCLHKDTNQQHPEPHS