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TPO1_1

Gene
TPO1_1
Protein
Multidrug transporter TPO1_1
Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)
Length
567 amino acids
Function
Multidrug resistance transporter involved in resistance to azole antifungal drugs such as the imidazoles miconazole, ketoconazole, and tioconazole; as well as the triazoles itraconazole and fluconazole (PubMed:26512119). Plays also a role in the resistance to other antifungal drug families such as the polyene amphotericin B, the pyrimide analog flucytosine, the fungicide mancozeb, and the polyamine spermine (PubMed:26512119). Decreases the intracellular accumulation of clotrimazole by mediating its extrusion from cells (PubMed:26512119, PubMed:27148215). Involved in virulence by confering resistance to the human antimicrobial peptide histatin-5 (PubMed:27780306).
Similarity
Belongs to the major facilitator superfamily. DHA1 family. Polyamines/proton antiporter (TC 2.A.1.2.16) subfamily.
Mass
62.56 kDa
Sequence
MVEEISPKYTNEQAEASSSSSSSVSGEPKDFSGSLENQEDLGELIERTNTMTSGAESKVETNRRMSRILTGTQDDPEKIAIDYSNCPPMGGDRPFPPALPEQSQFEVTFDGPNDPIHPFNWSMKTKTIICIVLCLNCICISMGSSIFASGVPQICKIYHVIPVVAILGVTLYVFGFAASPVIYAPLSEVYGRRGVLVISAFGFAVFQFAVATSKDLQSIMICRFFGGLIGAAPMAVVPAAFADMFDVRVRGKAICLFSLGVFVGPILSPVMGSYIAQRTTWRWLEYVTGCFASALFVAVALTFKETHHPTILVQKAKEMRKSTNNWGIHAAHEHVELSVSEIAKKTITRPIKMLFTEPLLLIITIYNSFVYGILYLMLEAYPIVFVEGYGFEANGELPYIALIIGMLVCTAFLWYFENDYLKRIQKAGKLVPEARLIPMVYAGVIFPIGILWFCWTGYYPHKIHWMCPTVAGSFIGFGLMGIFLPCLNYIIESYLPLAASAVAANTFMRSAFGAVFPLFAGYMFHGMGTGWAGLLLGLFAAALIPVPLFFLKYGERIRKNSKDAYYA