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TOPP4

Gene
TOPP4
Protein
Serine/threonine-protein phosphatase PP1 isozyme 4
Organism
Arabidopsis thaliana
Length
321 amino acids
Function
Serine/threonine-protein phosphatase that possesses phosphatase activity toward para-nitrophenyl phosphate (pNPP) in vitro (PubMed:21222654). Acts as positive regulator in the gibberellin (GA) signaling pathway to regulate plant growth and development. Promotes the GA-induced and proteasomal-dependent degradation of the DELLA proteins RGA and GAI by directly binding and dephosphorylating these proteins (PubMed:25010794). Involved in the regulation of phytochrome B (phyB) signaling pathway that controls photomorphogenesis. Promotes the proteasomal-dependent degradation of PIF5 factor by directly binding and dephosphorylating this protein (PubMed:26704640). Involved in the regulation of pavement cell (PC) interdigitation by modulating the auxin efflux carrier PIN1 polarity and endocytic trafficking. Regulates PIN1 polar targeting through direct binding and dephosphorylation. Acts antagonistically with PID in regulating PC development (PubMed:25560878).
Similarity
Belongs to the PPP phosphatase family. PP-1 subfamily.
Mass
36.372 kDa
Sequence
MATTTTTQGQQTAIDSAVLDDIIRRLTEVRLARPGKQVQLSEAEIKQLCTTARDIFLQQPNLLELEAPIKICGDIHGQYSDLLRLFEYGGFPPSANYLFLGDYVDRGKQSLETICLLLAYKIKYPGNFFLLRGNHECASINRIYGFYDECKRRFNVRVWKVFTDCFNCLPVAALIDDKILCMHGGLSPDLDHLDEIRNLPRPTMIPDTGLLCDLLWSDPGKDVKGWGMNDRGVSYTFGPDKVSEFLTKHDLDLVCRAHQVVEDGYEFFADRQLVTVFSAPNYCGEFDNAGAMMSVDENLMCSFQILKPAEKKTKFMMSTKI