Organism
Thermococcus onnurineus (strain NA1)
Function
Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO.
Similarity
Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.
Sequence
MKAKVRILDMYSGRYSVFINEKEAKKAKLHPDDLVKLETGKKTVYGSVTISNLVKEGEIGISKDVLQLHNFSEGEVVTVLPSGAPESVRYIKKKMNGEKLRKVEIETIVKDIVDRKLRDIEISSFVTALEINGLDMDEIAALTIAMAETGDMLDIDRKPIMDVHSIGGVPGNKTNILVVPIVAAAGLTIPKTSSRAITSAAGTADVVEVFAEVSFSLDEIKRIVEKIGACMVWGGALNLAPADDITIKAERALSIDPVGLMLASIMSKKYAMGSQYVLIDIPTGKGVKVETVDEARALARDFIELGKRLGQYVEVAITYGGQPIGHTVGPALEAREALQALMSGTGPGSLIEKATGLAGILLEMGGVAPSGMGKKMAREILESGKAYQKMREIIEEQGGNPDIKPEEIPIGDKTYTFTAPTSGYITAIDNKAITGIARAAGAPEDKGAGIELYVKVGEKVKEGDPLFTIYAESEARLDQAIVFARRAEPIRIEGMVLQRIGNI