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TOLLIP

Gene
tollip
Protein
Toll-interacting protein
Organism
Danio rerio
Length
276 amino acids
Function
Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates. The TOLLIP-dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates (By similarity).
Similarity
Belongs to the tollip family.
Mass
30.424 kDa
Sequence
MATTISTQRGQVYIGELPQDFLRIMPTQQQQQVQLDAQAARQLQYGGSLGTAGRLSITVVQAKLAKNYGMTRMDPYCRIRLGYAVYETPTAHNGAKNPRWNKVIQCTVPPGVDSFYLEIFDERAFSMDDRIAWTHVTIPENLREGTVVDEWYSLSGRQGDDKEGMINLVMSFATIPAGMMMQPQPVVLMPTVYQQGVGYVPIAGVPGMYNQGVVPMGMPAAAPVASQSAPCSEEDLKALQDMFPNLDKEVIRTVLEAQQGNKDAAINSLLQMAEEL

Gene
tollip
Protein
Toll-interacting protein
Organism
Esox lucius
Length
275 amino acids
Function
Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates. The TOLLIP-dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates (By similarity).
Similarity
Belongs to the tollip family.
Mass
30.319 kDa
Sequence
MATTISTQRGQVYIGELPQDFLRITPTQQQQQVQLDAQAAQQLQYGGSLGTVGRLSITVVQAKLAKNYGMTRMDPYCRVRLGYAVYETPTAHNGAKNPRWNKVIQCTVPPGVGSFYLEIFDERAFSMDDRIAWTHVTIPEGLREGSVVDEWYSLSDRQGDDKEGMINLVMSFANMPAGMHMSPPVVLMPTVYQQGVGYIPIAGVPTAYSPGMVPMGMPAAPTVTPQEAPCSEEDLKALQDMFPNLDREVIRTVIEAQQGNKDAAINSLLQMTEEL

Gene
tollip
Protein
Toll-interacting protein
Organism
Salmo salar
Length
275 amino acids
Function
Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates. The TOLLIP-dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates (By similarity).
Similarity
Belongs to the tollip family.
Mass
30.367 kDa
Sequence
MSTTISTQRGQVYIGELPQDFLRITPTQQQQQVQLDAQAAQQLQYGGSLGTVGRLSITVVQAKLAKNYGMTRMDPYCRVRLGYAVYETPTAHNGAKNPRWNKVIQCTVPPGVDSFYLEIFDERAFSMDDRIAWTHVTIPEGLREGSVVDEWYSLSGRQGDDKEGMINLVMSYANMPAGMHMSPPVVLMPTVYQQGVGYVPIAGVPTVYNQGMVPMGMPAAPTVAAQEAPCSEEDLKALQDMFPNLDREVIRTVIEAQQGNKDAAINSLLQMTEEL

Gene
TOLLIP
Protein
Toll-interacting protein
Organism
Gallus gallus
Length
274 amino acids
Function
Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates. The TOLLIP-dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates (By similarity).
Similarity
Belongs to the tollip family.
Mass
30.54 kDa
Sequence
MATTVSTQRGPVYVGELPQDFLRITPTQQQQQIQLDAQAAQQLQYGGPMSTVGRLSITVVQAKLAKNYGMTRMDPYCRIRLGYAVYETPTAHNGAKNPRWNKVIQCTVPPGVDSFYLEIFDERAFSMDDRIAWTHITIPESLKQGNVEDEWYSLSGRQGDDKEGMINLVMSYTSLPAAMMMQPQPVVLMPTVYQQGVGYVPIAGMPAVCNPDMVPVAIPPPAVNPQHLCNEEDLKSIQDMFPNMDREVIRSVLEAQRGNKNAAINSLLQMTEES

Gene
TOLLIP
Protein
Toll-interacting protein
Organism
Homo sapiens
Length
274 amino acids
Function
Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Recruits IRAK1 to the IL-1 receptor complex. Inhibits IRAK1 phosphorylation and kinase activity (PubMed:11751856). Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates. The TOLLIP-dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates (PubMed:25042851).
Similarity
Belongs to the tollip family.
Mass
30.282 kDa
Sequence
MATTVSTQRGPVYIGELPQDFLRITPTQQQRQVQLDAQAAQQLQYGGAVGTVGRLNITVVQAKLAKNYGMTRMDPYCRLRLGYAVYETPTAHNGAKNPRWNKVIHCTVPPGVDSFYLEIFDERAFSMDDRIAWTHITIPESLRQGKVEDKWYSLSGRQGDDKEGMINLVMSYALLPAAMVMPPQPVVLMPTVYQQGVGYVPITGMPAVCSPGMVPVALPPAAVNAQPRCSEEDLKAIQDMFPNMDQEVIRSVLEAQRGNKDAAINSLLQMGEEP

Gene
Tollip
Protein
Toll-interacting protein
Organism
Mus musculus
Length
274 amino acids
Function
Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Recruits IRAK1 to the IL-1 receptor complex. Inhibits IRAK1 phosphorylation and kinase activity. Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates. The TOLLIP-dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates (By similarity).
Similarity
Belongs to the tollip family.
Mass
30.345 kDa
Sequence
MATTVSTQRGPVYIGELPQDFLRITPTQQQQQIQLDAQAAQQLQYGGTVGTVGRLSITVVQAKLAKNYGMTRMDPYCRLRLGYAVYETPTAHNGAKNPRWNKVIQCTVPPGVDSFYLEIFDERAFSMDDRIAWTHITIPESLKQGQVEDEWYSLSGRQGDDKEGMINLVMSYTSLPAAMMMPPQPVVLMPTVYQQGVGYVPIAGMPAVCSPGMVPMAMPPPAVAPQPRCNEEDLKAIQDMFPNMDREVIRSVLEAQRGNKDAAINSLLQMGEES

Gene
Tollip
Protein
Toll-interacting protein
Organism
Rattus norvegicus
Length
274 amino acids
Function
Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Recruits IRAK1 to the IL-1 receptor complex. Inhibits IRAK1 phosphorylation and kinase activity. Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates. The TOLLIP-dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates (By similarity).
Similarity
Belongs to the tollip family.
Mass
30.315 kDa
Sequence
MATTVSTQRGPVYIGELPQDFLRITPTQQQQQIQLDAQAAQQLQYGGAVGTVGRLSITVVQAKLAKNYGMTRMDPYCRLRLGYAVYETPTAHNGAKNPRWNKVIQCTVPPGVDSFYLEIFDERAFSMDDRIAWTHITIPESLKQGQVEDEWYSLSGRQGDDKEGMINLVMSYTSLPAAMMMPPQPVVLMPTVYQQGVGYVPIAGMPAVCSPGMVPMAMPPPAVAPQPRCNEEDLKAIQDMFPNMDREVIRSVLEAQRGNKDAAINSLLQMGEES

Gene
TOLLIP
Protein
Toll-interacting protein
Organism
Bos taurus
Length
273 amino acids
Function
Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Recruits IRAK1 to the IL-1 receptor complex. Inhibits IRAK1 phosphorylation and kinase activity. Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates. The TOLLIP-dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates (By similarity).
Similarity
Belongs to the tollip family.
Mass
30.082 kDa
Sequence
MATTVSTQRGPVYIGELPQDFLRITPTQQQQQIQLDAQAAQQLQYGGALGTVGRLSVTVVQAKLAKNYGMTRMDPYCRLRLGYAVYETPTAHNGAKNPRWNKVIQCTVPPGVDSFYLEIFDERAFSMDDRIAWTHVTIPEALKQGKVVDEWYSLSGRQGDDKEGMINLVLSYTSLPAAMMMPPQPVVLMPTVYQQGVGYVPITGMPTVCSPGVVPVALPPAVSAQPRCSEEDLKAIQDMFPNMDREVIRSVLEAQRGSRDAAINSLLQMGEES

Gene
tollip
Protein
Toll-interacting protein
Organism
Xenopus tropicalis
Length
269 amino acids
Function
Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates. The TOLLIP-dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates (By similarity).
Similarity
Belongs to the tollip family.
Mass
30.069 kDa
Sequence
MATSISTQRGQVFIGELPQDFLRITPTQQQQQIQLDAQAAQQLQYSGVMGTMGRLSITVVQAKLAKNYGMTRMDPYCRIRLGYAVYETPTAHNGAKNPRWNKVIQCTIPPGVDSFYLEIFDERAFSMDDRIAWTHITIPETLKEGKHVDEWFSLSGRQGDDKEGMINLVMSYTSVPAMMPQQPVVLMPTVYQQGVGYVPIAGPIYNPGMPMAAPPPAVNPQHQTREEDIKFIKDMFPTMDPEVIRSVLEAQGGNRDAAVNSLLQMVEDS