Protein
Tumor necrosis factor alpha-induced protein 8-like protein 2
Organism
Rhinolophus ferrumequinum
Function
Acts as a negative regulator of innate and adaptive immunity by maintaining immune homeostasis. Negative regulator of Toll-like receptor and T-cell receptor function. Prevents hyperresponsiveness of the immune system and maintains immune homeostasis. Inhibits JUN/AP1 and NF-kappa-B activation. Promotes Fas-induced apoptosis (By similarity).
Similarity
Belongs to the TNFAIP8 family. TNFAIP8L2 subfamily.
Sequence
MEPFSSKSLALQAEKKLLSKMAGRSVAHLFIDETSSAVLDELYRVSKEYTHSRPQAQRVIKDLIKVAVKVAVLHRSGCFGPSELALAARFRQKLQQGAMTALSFGEVDFTFEAAVLAGLLTECRDMLLELVEHHLTPKSHNRIRHVFDHFSDPGLLTALYGPDFTQHLGKICDGLRKMLDEGKL