About Products Protein Database Contact

TNC

Gene
TNC
Protein
Tenascin
Organism
Homo sapiens
Length
2201 amino acids
Function
Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6. In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells (PubMed:19884327).
Similarity
Belongs to the tenascin family.
Mass
240.853 kDa
Sequence
MGAMTQLLAGVFLAFLALATEGGVLKKVIRHKRQSGVNATLPEENQPVVFNHVYNIKLPVGSQCSVDLESASGEKDLAPPSEPSESFQEHTVDGENQIVFTHRINIPRRACGCAAAPDVKELLSRLEELENLVSSLREQCTAGAGCCLQPATGRLDTRPFCSGRGNFSTEGCGCVCEPGWKGPNCSEPECPGNCHLRGRCIDGQCICDDGFTGEDCSQLACPSDCNDQGKCVNGVCICFEGYAGADCSREICPVPCSEEHGTCVDGLCVCHDGFAGDDCNKPLCLNNCYNRGRCVENECVCDEGFTGEDCSELICPNDCFDRGRCINGTCYCEEGFTGEDCGKPTCPHACHTQGRCEEGQCVCDEGFAGVDCSEKRCPADCHNRGRCVDGRCECDDGFTGADCGELKCPNGCSGHGRCVNGQCVCDEGYTGEDCSQLRCPNDCHSRGRCVEGKCVCEQGFKGYDCSDMSCPNDCHQHGRCVNGMCVCDDGYTGEDCRDRQCPRDCSNRGLCVDGQCVCEDGFTGPDCAELSCPNDCHGQGRCVNGQCVCHEGFMGKDCKEQRCPSDCHGQGRCVDGQCICHEGFTGLDCGQHSCPSDCNNLGQCVSGRCICNEGYSGEDCSEVSPPKDLVVTEVTEETVNLAWDNEMRVTEYLVVYTPTHEGGLEMQFRVPGDQTSTIIQELEPGVEYFIRVFAILENKKSIPVSARVATYLPAPEGLKFKSIKETSVEVEWDPLDIAFETWEIIFRNMNKEDEGEITKSLRRPETSYRQTGLAPGQEYEISLHIVKNNTRGPGLKRVTTTRLDAPSQIEVKDVTDTTALITWFKPLAEIDGIELTYGIKDVPGDRTTIDLTEDENQYSIGNLKPDTEYEVSLISRRGDMSSNPAKETFTTGLDAPRNLRRVSQTDNSITLEWRNGKAAIDSYRIKYAPISGGDHAEVDVPKSQQATTKTTLTGLRPGTEYGIGVSAVKEDKESNPATINAATELDTPKDLQVSETAETSLTLLWKTPLAKFDRYRLNYSLPTGQWVGVQLPRNTTSYVLRGLEPGQEYNVLLTAEKGRHKSKPARVKASTEQAPELENLTVTEVGWDGLRLNWTAADQAYEHFIIQVQEANKVEAARNLTVPGSLRAVDIPGLKAATPYTVSIYGVIQGYRTPVLSAEASTGETPNLGEVVVAEVGWDALKLNWTAPEGAYEYFFIQVQEADTVEAAQNLTVPGGLRSTDLPGLKAATHYTITIRGVTQDFSTTPLSVEVLTEEVPDMGNLTVTEVSWDALRLNWTTPDGTYDQFTIQVQEADQVEEAHNLTVPGSLRSMEIPGLRAGTPYTVTLHGEVRGHSTRPLAVEVVTEDLPQLGDLAVSEVGWDGLRLNWTAADNAYEHFVIQVQEVNKVEAAQNLTLPGSLRAVDIPGLEAATPYRVSIYGVIRGYRTPVLSAEASTAKEPEIGNLNVSDITPESFNLSWMATDGIFETFTIEIIDSNRLLETVEYNISGAERTAHISGLPPSTDFIVYLSGLAPSIRTKTISATATTEALPLLENLTISDINPYGFTVSWMASENAFDSFLVTVVDSGKLLDPQEFTLSGTQRKLELRGLITGIGYEVMVSGFTQGHQTKPLRAEIVTEAEPEVDNLLVSDATPDGFRLSWTADEGVFDNFVLKIRDTKKQSEPLEITLLAPERTRDITGLREATEYEIELYGISKGRRSQTVSAIATTAMGSPKEVIFSDITENSATVSWRAPTAQVESFRITYVPITGGTPSMVTVDGTKTQTRLVKLIPGVEYLVSIIAMKGFEESEPVSGSFTTALDGPSGLVTANITDSEALARWQPAIATVDSYVISYTGEKVPEITRTVSGNTVEYALTDLEPATEYTLRIFAEKGPQKSSTITAKFTTDLDSPRDLTATEVQSETALLTWRPPRASVTGYLLVYESVDGTVKEVIVGPDTTSYSLADLSPSTHYTAKIQALNGPLRSNMIQTIFTTIGLLYPFPKDCSQAMLNGDTTSGLYTIYLNGDKAEALEVFCDMTSDGGGWIVFLRRKNGRENFYQNWKAYAAGFGDRREEFWLGLDNLNKITAQGQYELRVDLRDHGETAFAVYDKFSVGDAKTRYKLKVEGYSGTAGDSMAYHNGRSFSTFDKDTDSAITNCALSYKGAFWYRNCHRVNLMGRYGDNNHSQGVNWFHWKGHEHSIQFAEMKLRPSNFRNLEGRRKRA

Gene
Tnc
Protein
Tenascin
Organism
Mus musculus
Length
2110 amino acids
Function
Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth when provided to neurons in culture. May play a role in supporting the growth of epithelial tumors. Ligand for integrins ITGA8:ITGB1, ITGA9:ITGB1, ITGAV:ITGB3 and ITGAV:ITGB6. In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells (By similarity).
Similarity
Belongs to the tenascin family.
Mass
231.807 kDa
Sequence
MGAVTWLLPGIFLALFALTPEGGVLKKIIRHKRESGLNMTLPEENQPVVFNHIYNIKLPMGSQCSVDLESASGEKDLTPTPESSGSFQEHTVDGENQIVFTHRINIPRRACGCAAAPDVKELLSRLEELELLVSSLREQCTMGTGCCLQPAEGRLDTRPFCSGRGNFSAEGCGCVCEPGWKGPNCSEPDCPGNCNLRGQCLDGQCICDEGFTGEDCSQLACPNDCNDQGRCVNGVCVCFEGYAGPDCGLEVCPVPCSEEHGMCVDGRCVCKDGFAGEDCNEPLCLNNCYNRGRCVENECVCDEGFTGEDCSELICPNDCFDRGRCINGTCYCEEGFTGEDCGELTCPNDCQGRGQCEEGQCVCNEGFAGADCSEKRCPADCHHRGRCLNGQCECDDGFTGADCGDLQCPNGCSGHGRCVNGQCVCDEGYTGEDCSQRRCPNDCHNRGLCVQGKCICEQGFKGFDCSEMSCPNDCHQHGRCVNGMCICDDDYTGEDCRDRRCPRDCSQRGRCVDGQCICEDGFTGPDCAELSCPSDCHGHGRCVNGQCICHEGFTGKDCKEQRCPSDCHGQGRCEDGQCICHEGFTGLDCGQRSCPNDCSNQGQCVSGRCICNEGYTGIDCSEVSPPKDLIVTEVTEETVNLAWDNEMRVTEYLIMYTPTHADGLEMQFRVPGDQTSTTIRELEPGVEYFIRVFAILENKRSIPVSARVATYLPAPEGLKFKSIKETSVEVEWDPLDIAFETWEIIFRNMNKEDEGEITKSLRRPETSYRQTGLAPGQEYEISLHIVKNNTRGPGLKKVTTTRLDAPSHIEVKDVTDTTALITWFKPLAEIDSIELSYGIKDVPGDRTTIDLTHEDNQYSIGNLRPDTEYEVSLISRRVDMASNPAKETFITGLDAPRNLRRVSQTDNSITLEWRNVKADIDSYRIKYAPISGGDHAEIDVPKSQQATTKTTLTGLRPGTEYGIGVSAVKGDKESDPATINAATEIDAPKDLRVSETTQDSLTFFWTTPLAKFDRYRLNYSLPTGQSMEVQLPKDATSHVLTDLEPGQEYTVLLIAEKGRHKSKPARVKASTEEVPSLENLTVTEAGWDGLRLNWTADDLAYEYFVIQVQEANNVETAHNFTVPGNLRAADIPGLKVATSYRVSIYGVARGYRTPVLSAETSTGTTPNLGEVTVAEVGWDALTLNWTAPEGAYKNFFIQVLEADTTQTVQNLTVPGGLRSVDLPGLKAATRYYITLRGVTQDFGTAPLSVEVLTEDLPQLGGLSVTEVSWDGLTLNWTTDDLAYKHFVVQVQEANNVEAAQNLTVPGSLRAVDIPGLKADTPYRVSIYGVIQGYRTPMLSTDVSTAREPEIGNLNVSDVTPKSFNLSWTATDGIFDMFTIEIIDSNRLLQTAEHNISGAERTAHISGLPPSTDFIVYLSGIAPSIRTKTISTTATTEALPLLENLTISDTNPYGFTVSWTASENAFDSFLVTVVDSGKLLDPQEFTLSGTQRKLELRGLITGIGYEVLVSGFTQGHQTKPLRAETITEAEPEVDNLLVSDATPDGFRLSWTADEGIFDSFVIRIRDTKKQSEPQEISLPSPERTRDITGLREATEYEIELYGISRGRRSQPVSAIATTAMGSPKEIMFSDITENAATVSWRAPTAQVESFRITYVPMTGGAPSMVTVDGTDTETRLVKLTPGVEYRVSVIAMKGFEESDPVSGTLITALDGPSGLLIANITDSEALAMWQPAIATVDSYVISYTGERVPEVTRTVSGNTVEYELHDLEPATEYILSIFAEKGQQKSSTIATKFTTDLDSPREFTATEVQSETALLTWRPPRASVTGYLLVYESVDGTVKEVIVGPDTTSYSLADLSPSTHYSARIQALSGSLRSKLIQTIFTTIGLLYPFPRDCSQAMLNGDTTSGLYTIYINGDKTQALEVYCDMTSDGGGWIVFLRRKNGREDFYRNWKAYAAGFGDRREEFWLGLDNLSKITAQGQYELRVDLQDHGESAYAVYDRFSVGDAKSRYKLKVEGYSGTAGDSMNYHNGRSFSTYDKDTDSAITNCALSYKGAFWYKNCHRVNLMGRYGDNNHSQGVNWFHWKGHEYSIQFAEMKLRPSNFRNLEGRRKRA

Gene
TNC
Protein
Tenascin
Organism
Gallus gallus
Length
1808 amino acids
Function
Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6.
Similarity
Belongs to the tenascin family.
Mass
198.859 kDa
Sequence
MGLPSQVLACAILGLLYQHASGGLIKRIIRQKRETGLNVTLPEDNQPVVFNHVYNIKLPVGSLCSVDLDTASGDADLKAEIEPVKNYEEHTVNEGNQIVFTHRINIPRRACGCAAAPDIKDLLSRLEELEGLVSSLREQCASGAGCCPNSQTAEGRLDTAPYCSGHGNYSTEICGCVCEPGWKGPNCSEPACPRNCLNRGLCVRGKCICEEGFTGEDCSQAACPSDCNDQGKCVDGVCVCFEGYTGPDCGEELCPHGCGIHGRCVGGRCVCHEGFTGEDCNEPLCPNNCHNRGRCVDNECVCDEGYTGEDCGELICPNDCFDRGRCINGTCFCEEGYTGEDCGELTCPNNCNGNGRCENGLCVCHEGFVGDDCSQKRCPKDCNNRGHCVDGRCVCHEGYLGEDCGELRCPNDCHNRGRCINGQCVCDEGFIGEDCGELRCPNDCHNRGRCVNGQCECHEGFIGEDCGELRCPNDCNSHGRCVNGQCVCDEGYTGEDCGELRCPNDCHNRGRCVEGRCVCDNGFMGEDCGELSCPNDCHQHGRCVDGRCVCHEGFTGEDCRERSCPNDCNNVGRCVEGRCVCEEGYMGIDCSDVSPPTELTVTNVTDKTVNLEWKHENLVNEYLVTYVPTSSGGLDLQFTVPGNQTSATIHELEPGVEYFIRVFAILKNKKSIPVSARVATYLPAPEGLKFKSVRETSVQVEWDPLSISFDGWELVFRNMQKKDDNGDITSSLKRPETSYMQPGLAPGQQYNVSLHIVKNNTRGPGLSRVITTKLDAPSQIEAKDVTDTTALITWSKPLAEIEGIELTYGPKDVPGDRTTIDLSEDENQYSIGNLRPHTEYEVTLISRRGDMESDPAKEVFVTDLDAPRNLKRVSQTDNSITLEWKNSHANIDNYRIKFAPISGGDHTELTVPKGNQATTRATLTGLRPGTEYGIGVTAVRQDRESAPATINAGTDLDNPKDLEVSDPTETTLSLRWRRPVAKFDRYRLTYVSPSGKKNEMEIPVDSTSFILRGLDAGTEYTISLVAEKGRHKSKPTTIKGSTEEEPELGNLSVSETGWDGFQLTWTAADGAYENFVIQVQQSDNPEETWNITVPGGQHSVNVTGLKANTPYNVTLYGVIRGYRTKPLYVETTTGAHPEVGELTVSDITPESFNLSWTTTNGDFDAFTIEIIDSNRLLEPMEFNISGNSRTAHISGLSPSTDFIVYLYGISHGFRTQAISAAATTEAEPEVDNLLVSDATPDGFRLSWTADDGVFDSFVLKIRDTKRKSDPLELIVPGHERTHDITGLKEGTEYEIELYGVSSGRRSQPINSVATTVVGSPKGISFSDITENSATVSWTPPRSRVDSYRVSYVPITGGTPNVVTVDGSKTRTKLVKLVPGVDYNVNIISVKGFEESEPISGILKTALDSPSGLVVMNITDSEALATWQPAIAAVDNYIVSYSSEDEPEVTQMVSGNTVEYDLNGLRPATEYTLRVHAVKDAQKSETLSTQFTTGLDAPKDLSATEVQSETAVITWRPPRAPVTDYLLTYESIDGRVKEVILDPETTSYTLTELSPSTQYTVKLQALSRSMRSKMIQTVFTTTGLLYPYPKDCSQALLNGEVTSGLYTIYLNGDRTQPLQVFCDMAEDGGGWIVFLRRQNGKEDFYRNWKNYVAGFGDPKDEFWIGLENLHKISSQGQYELRVDLRDRGETAYAVYDKFSVGDAKTRYRLRVDGYSGTAGDSMTYHNGRSFSTFDKDNDSAITNCALSYKGAFWYKNCHRVNLMGRYGDNNHSQGVNWFHWKGHEYSIQFAEMKLRPSSFRNLEGRRKRA

Gene
TNC
Protein
Tenascin
Organism
Sus scrofa
Length
1746 amino acids
Function
Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6. In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells (By similarity).
Similarity
Belongs to the tenascin family.
Mass
191.4 kDa
Sequence
MGVVTRLLVGTFLASLALPAQGGVLKKVIRHKRQTGVNVTLPEESQPVVFNHVYNIKLPVGSQCSVDLESASGDKDLAAPSEPSESVQEHTVDGENQIVFTHRINIPRRACGCAAAPDVKELLSRLEELENLVSSLREQCTSGAGCCLQPAEGRLDTRPFCSGRGNFSTEGCGCVCEPGWKGPNCSEPECPSNCHLRGQCVDGQCVCNEGFTGEDCSQLACPSDCNDQGKCVNGVCVCFEGYSGVDCSRETCPVPCSEEHGRCVDGRCVCQEGFAGEDCNEPLCLHNCHGRGRCVENECVCDEGFTGEDCGELICPKDCFDRGRCINGTCYCDEGFEGEDCGRLACPHGCRGRGRCEEGQCVCDEGFAGADCSERRCPSDCHNRGRCLDGRCECDDGFEGEDCGELRCPGGCSGHGRCVNGQCVCDEGRTGEDCSQLRCPNDCHGRGRCVQGRCECEHGFQGYDCSEMSCPHDCHQHGRCVNGMCVCDDGYTGEDCRELRCPGDCSQRGRCVDGRCVCEHGFAGPDCADLACPSDCHGRGRCVNGQCVCHEGFTGKDCGQRRCPGDCHGQGRCVDGQCVCHEGFTGLDCGQRSCPNDCSNWGQCVSGRCICNEGYSGEDCSQVSPPKDLIVTEVTEETVNLAWDNEMRVTEYLIVYTPTHEDGLEMQFRVPGDQTSTTIRELEPGVEYFIRVFAILENKKSIPVSARVATYLPTPEGLKFKSIKETSVEVEWDPLDIAFETWEIIFRNMNKEDEGEITKSLRRPETTYRQTGLAPGQEYEISLHIVKNNTRGPGLKRVTTTRLDAPSQIEAKDVTDTTALITWFKPLAEIDGIELTYGIKDVPGDRTTIDLTHEENQYSIGNLKPDTEYEVSLISRRADMSSNPAKETFTTGLDAPRNLRRISQTDNSITLEWRNGKAAADTYRIKYAPISGGDHAEVEVPRSPQTTTKATLTGLRPGTEYGIGVSAVKGDKESDPATINAATDLDPPKDFRVSELKESSLTLLWRTPLAKFDRYRLNYGLPSGQPVEVQLPRNATSYILRGLEPGQEYTILLTAEKGRHKSKPARVKASTAGEPEIGNLSVSDITPESFSLSWTATEGAFETFTIEIIDSNRFLETMEYNISGAERTAHISGLRPGNDFIVYLSGLAPGIQTKPISATATTEAEPEVDNLLVSDATPDGFRLSWTADEGVFDSFVLKIRDTKKQSEPLEITLLASERTRDITGLREATEYEIELYGISSGKRSQPVSAIATTAMGSPKEITFSDITENSATVSWMVPTAQVESFRITYVPITGGAPSVVTVDGTKTQTRLLRLLPGVEYLVSVIAVKGFEESEPVSGTLTTALDGPSGLVTANITDSEALAMWQPAIAPVDHYVISYTGDRVPEITRTVSGNTVEYALTNLEPATEYTLRIFAEKGPQKSSTITTKFTTDLDSPRDLTATEVQSETALLTWRPPRASVTGYLLVYESVDGTLKEVVVGPETTSYSLSGLSPSTHYTARIQALNGPLRSKMSQTVFTTIGLLYPFPRDCSQAMLNGDTTSGLYTIYVNNDKAQKLEVFCDMTSDSGGWIVFLRRKNGREDFYRNWKAYAAGFGDLKEEFWLGLDALSKITAQGQYELRVDLRDHGETAYAVYDRFSVGDARTRYKLKVEGYSGTAGDSMAYHNGRSFSTFDKDTDSAITNCALSYKGAFWYKNCHRVNLMGRYGDNSHSQGVNWFHWKGHEYSIQFAEMKLRPSNFRNLEGRRKRA