About Products Protein Database Contact

TMEM175

Gene
tmem175
Protein
Endosomal/lysosomal potassium channel TMEM175
Organism
Danio rerio
Length
520 amino acids
Function
Organelle-specific potassium channel specifically responsible for potassium conductance in endosomes and lysosomes. Forms a potassium-permeable leak-like channel.
Similarity
Belongs to the TMEM175 family.
Mass
59.013 kDa
Sequence
MGENDESEIIEHHDDEEMEKRRPPRTHAQSFLESVASSVKEGHSSTQSSHRLLAYSDALISIIATVMILPVAHTKIQEDEELKQSIQALLTTKIAVYLMTFLIVTVAWAAHIRLFQVIERIDDTLALLNLACMMLITFLPYTFSLMATFPNNILGILLFCACVMVIGLIQALIVLYGFSHPFLLNDQIQMSENQAYYKQHILKVIMRVPIMCLFASIFSFIFFQLSYVLLAIVIFLPYISQCLKWIRSKAIGGQTDESPDSMPFYTYHPSEPLSKERVEAFSDGVFAIVATLLILDICEGNVPDPSVVKKKFDNSLIAALQEYGPEYLAYFGSFVTVGLLWFVHHSLFLHVTKATRLMGLFNTFSLAFVGGLPLAYQLTHESPRGSRNELEAVQISCVIIFFASLFQLAIWVTALFTERETLHPYVRYGGREHTFMLAKLSLYPCVALGTFFITCILSRFSAPIFHMMEICIPFAFLLLRLLVRVALALLRWLFCSARNDLERIPVEEEESRLPINDIVT
Protein
Endosomal/lysosomal potassium channel TMEM175: tmem175

Gene
TMEM175
Protein
Endosomal/lysosomal potassium channel TMEM175
Organism
Homo sapiens
Length
504 amino acids
Function
Organelle-specific potassium channel specifically responsible for potassium conductance in endosomes and lysosomes. Forms a potassium-permeable leak-like channel, which regulates lumenal pH stability and is required for autophagosome-lysosome fusion. Constitutes the major lysosomal potassium channel.
Similarity
Belongs to the TMEM175 family.
Mass
55.615 kDa
Sequence
MSQPRTPEQALDTPGDCPPGRRDEDAGEGIQCSQRMLSFSDALLSIIATVMILPVTHTEISPEQQFDRSVQRLLATRIAVYLMTFLIVTVAWAAHTRLFQVVGKTDDTLALLNLACMMTITFLPYTFSLMVTFPDVPLGIFLFCVCVIAIGVVQALIVGYAFHFPHLLSPQIQRSAHRALYRRHVLGIVLQGPALCFAAAIFSLFFVPLSYLLMVTVILLPYVSKVTGWCRDRLLGHREPSAHPVEVFSFDLHEPLSKERVEAFSDGVYAIVATLLILDICEDNVPDPKDVKERFSGSLVAALSATGPRFLAYFGSFATVGLLWFAHHSLFLHVRKATRAMGLLNTLSLAFVGGLPLAYQQTSAFARQPRDELERVRVSCTIIFLASIFQLAMWTTALLHQAETLQPSVWFGGREHVLMFAKLALYPCASLLAFASTCLLSRFSVGIFHLMQIAVPCAFLLLRLLVGLALATLRVLRGLARPEHPPPAPTGQDDPQSQLLPAPC
Protein
Endosomal/lysosomal potassium channel TMEM175: TMEM175

Gene
TMEM175
Protein
Endosomal/lysosomal potassium channel TMEM175
Organism
Gallus gallus
Length
501 amino acids
Function
Organelle-specific potassium channel specifically responsible for potassium conductance in endosomes and lysosomes. Forms a potassium-permeable leak-like channel.
Similarity
Belongs to the TMEM175 family.
Mass
56.098 kDa
Sequence
MAAPRAATPGPGGGARKPELDLELGSSTQTSHRLLAYSDALLSIIATVMILPVAHTKIHPDQKLGESVQQLLLTKIAVYLMTFLIVTVAWAAHVRLFQVIELIDDVLALLNLACMMIITFLPYTFSLMASFPGVPFGIFLFSVCAVVIGLIQAVIVVYGFYHPHLLNQQIQVSENQNFYKRHILKIILRGPALCFLAAIFSFFFIPLSYLLLGLVIVFPHLSRFITWCKTKIVGHRDEEEASYSLETFSFYLSEPLSKERVEAFSDGVYAIVATLLILDICEDNVPDPREVGEKFHGSLLEALSEYGPNYLAYFGSFVTIGLLWFVHHSLFLYVTKATRLMGLLNILSLAFIGGLPLAYQLTSEFAEKSHNEIEAIQVSCVITFFASIFQFAIWTTALLHERETLHPFARYGGKEHAFMFAKLALYPCVSLGAFFLTCLLSEFSTEIFHLMQIVIPFAFLALRIFVRISLTVIKSVMSLSRRKVVLLEEEEACLSPTETHS
Protein
Endosomal/lysosomal potassium channel TMEM175: TMEM175

Gene
Tmem175
Protein
Endosomal/lysosomal potassium channel TMEM175
Organism
Mus musculus
Length
499 amino acids
Function
Organelle-specific potassium channel specifically responsible for potassium conductance in endosomes and lysosomes. Forms a potassium-permeable leak-like channel, which regulates lumenal pH stability and is required for autophagosome-lysosome fusion. Constitutes the major lysosomal potassium channel.
Similarity
Belongs to the TMEM175 family.
Mass
55.578 kDa
Sequence
MSRLQTEEQAVDSEGDSSLHRRNEEGTQSSHRMLGFSDALLSIIATVMILPVTHTEISPEQQFDKSIQKLLATRIAVYLMTFLIVTVAWTAHTRLFQVVGKIDDTLALLNLACMMTITLLPYTFSLMVTFPDVPLGIFLFCVCVIAIGSVQAMIVGYAFHFPHLLNPQIQCSTHRDLSRRHILHLVLRGPALCFVAAVFSLFFFPLSYLLMVTVIFLPHISKATTWCKDKLMGQRESPAHDMEPFSIDLHAPLSKERVEAFSDGVYAIVATLLILDICEDNVPDPKDVQEKFSGSLVAALGAYGPQFLAYFGSFATVGLLWFAHHSLFLHVRKATQTMGLLNILSLAFVGGLPLAYQQTSAFARQPHDELERVRVSCAIIFFASIFQFAIWTTALLHQTETLQPAVQFGGQEHAFMFAKLALYPCASLLAFAATCLLSRFSTAIFHLMQISVPFAFLLLRLLVRLALAGLQVLRGLWPHHPQQDQSEPEAQSQLLPDPC
Protein
Endosomal/lysosomal potassium channel TMEM175: Tmem175

Gene
Tmem175
Protein
Endosomal/lysosomal potassium channel TMEM175
Organism
Rattus norvegicus
Length
499 amino acids
Function
Organelle-specific potassium channel specifically responsible for potassium conductance in endosomes and lysosomes. Forms a potassium-permeable leak-like channel, which regulates lumenal pH stability and is required for autophagosome-lysosome fusion. Constitutes the major lysosomal potassium channel.
Similarity
Belongs to the TMEM175 family.
Mass
55.706 kDa
Sequence
MSRLQVQEQAVDSEGDSSLYRRDEEGTQSSHRMLGFSDALLSIIATVMILPVTHTEISPEQQFDKSIQKLLATRIAVYLMTFLIVTVAWAAHTRLFQVVGKIDDTLALLNLACMMTITLLPYTFSLMVTFPDVPLGIFLFCMCVIAIGSVQAMIVGYAFHFPHLLNPQIQCSTHRALSRRHILHLVLRGPALCFVAAVFSLFFFPLSYLLMVTVIFLPHISKATTWCKDKFMGHRESPAHNVEPFSIDLHAPLSKERVEAFSDGVYAIVATLLILDICEDNVPDPKDVQQKFSGSLVAALGAYGPQFLAYFGSFATVGLLWFAHHSLFLHVRKATQTMGLFNILSLAFVGGLPLAYQQTSAFARQPRDELERVRVSCAIIFFASIFQFAIWTTALLHQRETLQPAVQFGGQEHAFMFAKLALYPCASLLAFAATCLLSRFSTAIFHLMQIAVPFAFLLLRLLVRLALAGLQVLWDLWPERPQQDQGEPETQSQLLPASC
Protein
Endosomal/lysosomal potassium channel TMEM175: Tmem175

Gene
TMEM175
Protein
Endosomal/lysosomal potassium channel TMEM175
Organism
Bos taurus
Length
479 amino acids
Function
Organelle-specific potassium channel specifically responsible for potassium conductance in endosomes and lysosomes. Forms a potassium-permeable leak-like channel, which regulates lumenal pH stability and is required for autophagosome-lysosome fusion. Constitutes the major lysosomal potassium channel.
Similarity
Belongs to the TMEM175 family.
Mass
51.966 kDa
Sequence
MSGPQAPEPTLEGQADASAGSPDEDAAEGIQHSHRMLSFSDALLSIIATVMEFDKSVQRLLATRIAVYLMTFLIVTVAWAAHTRLFQVVGKIDDTLALLNLFSLMVTFPEVPLGIFLFCMCVIAIGAVQALIVLYAFHFPHLLSPQIERSAHRGLYRQRVLGIIVRGPALCLAAAGFSLFFYPASYLLMAMVIVLPHVSKAAGWCRAQLVGPREPPAHSVEVFTFDLHEPLSKERVEAFSDGVYAIVATLLILDICEDNVPDAKDVKEKFQGSLVAALGESGPHFLAYFGSFATVGLLWFAHHSLFLHIRRATQPMGLLNTLSLAFVGGLPLAYQQTSAFTKQPRDELESVRISCAIIFLASIFQFAIWTTALLQEGETLQPSARFGGREHAFMFAKLALYPCASLLAFACTCVLSSFSTAIFHAMQIAVPFAFLLLRLLVRLALAGLRALRGLVGPVLARPAPGAADEAQSPLLPAPC
Protein
Endosomal/lysosomal potassium channel TMEM175: TMEM175