TMEM131L

Gene

TMEM131L

Protein

Transmembrane protein 131-like

Organism

Homo sapiens

Length

1609 amino acids

Function

Isoform 1: Membrane-associated form that antagonizes canonical Wnt signaling by triggering lysosome-dependent degradation of Wnt-activated LRP6. Regulates thymocyte proliferation.

Similarity

Belongs to the TMEM131 family.

Mass

179.339 kDa

Sequence

MAGLRRPQPGCYCRTAAAVNLLLGVFQVLLPCCRPGGAQGQAIEPLPNVVELWQAEEGELLLPTQGDSEEGLEEPSQEQSFSDKLFSGKGLHFQPSVLDFGIQFLGHPVAKILHAYNPSRDSEVVVNSVFAAAGHFHVPPVPCRVIPAMGKTSFRIIFLPTEEGSIESSLFINTSSYGVLSYHVSGIGTRRISTEGSAKQLPNAYFLLPKVQSIQLSQMQAETTNTSLLQVQLECSLHNKVCQQLKGCYLESDDVLRLQMSIMVTMENFSKEFEENTQHLLDHLSIVYVATDESETSDDSAVNMYILHSGNSLIWIQDIRHFSQRDALSLQFEPVLLPTSTTNFTKIASFTCKATSCDSGIIEDVKKTTHTPTLKACLFSSVAQGYFRMDSSATQFHIETHENTSGLWSIWYRNHFDRSVVLNDVFLSKETKHMLKILNFTGPLFLPPGCWNIFSLKLAVKDIAINLFTNVFLTTNIGAIFAIPLQIYSAPTKEGSLGFEVIAHCGMHYFMGKSKAGNPNWNGSLSLDQSTWNVDSELANKLYERWKKYKNGDVCKRNVLGTTRFAHLKKSKESESFVFFLPRLIAEPGLMLNFSATALRSRMIKYFVVQNPSSWPVSLQLLPLSLYPKPEALVHLLHRWFGTDMQMINFTTGEFQLTEACPYLGTHSEESRFGILHLHLQPLEMKRVGVVFTPADYGKVTSLILIRNNLTVIDMIGVEGFGARELLKVGGRLPGAGGSLRFKVPESTLMDCRRQLKDSKQILSITKNFKVENIGPLPITVSSLKINGYNCQGYGFEVLDCHQFSLDPNTSRDISIVFTPDFTSSWVIRDLSLVTAADLEFRFTLNVTLPHHLLPLCADVVPGPSWEESFWRLTVFFVSLSLLGVILIAFQQAQYILMEFMKTRQRQNASSSSQQNNGPMDVISPHSYKSNCKNFLDTYGPSDKGRGKNCLPVNTPQSRIQNAAKRSPATYGHSQKKHKCSVYYSKHKTSTAAASSTSTTTEEKQTSPLGSSLPAAKEDICTDAMRENWISLRYASGINVNLQKNLTLPKNLLNKEENTLKNTIVFSNPSSECSMKEGIQTCMFPKETDIKTSENTAEFKERELCPLKTSKKLPENHLPRNSPQYHQPDLPEISRKNNGNNQQVPVKNEVDHCENLKKVDTKPSSEKKIHKTSREDMFSEKQDIPFVEQEDPYRKKKLQEKREGNLQNLNWSKSRTCRKNKKRGVAPVSRPPEQSDLKLVCSDFERSELSSDINVRSWCIQESTREVCKADAEIASSLPAAQREAEGYYQKPEKKCVDKFCSDSSSDCGSSSGSVRASRGSWGSWSSTSSSDGDKKPMVDAQHFLPAGDSVSQNDFPSEAPISLNLSHNICNPMTVNSLPQYAEPSCPSLPAGPTGVEEDKGLYSPGDLWPTPPVCVTSSLNCTLENGVPCVIQESAPVHNSFIDWSATCEGQFSSAYCPLELNDYNAFPEENMNYANGFPCPADVQTDFIDHNSQSTWNTPPNMPAAWGHASFISSPPYLTSTRSLSPMSGLFGSIWAPQSDVYENCCPINPTTEHSTHMENQAVVCKEYYPGFNPFRAYMNLDIWTTTANRNANFPLSRDSSYCGNV

Protein

Transmembrane protein 131-like: TMEM131L

Gene

TMEM131L

Protein

Transmembrane protein 131-like

Organism

Bos taurus

Length

1598 amino acids

Similarity

Belongs to the TMEM131 family.

Mass

174.577 kDa

Sequence

MAGPRRPQPGCYRRTAAAVNLLLGVFHVLLPCGRPGGAQGQAIEPMPNVVELWQAEEGELLLPTQGDSEDDTEEQSQEQSFSDKLFSGKGLHFQPSVLDFGVQFLGQPAAKILYAYNPSRESEVVVNSVFTAARHFHVPPVHCRVIPAMGKTSFRIIFLPTEEGSIESSLFINTSSHGVLSYHVSGFGTRVMSAKGSAEQLPNAYFLLPQVQTVQLSQTQAETTNSSLLQVQLECSLHNKVCQRLKSCYVESDDVLRLQMSIIVTMENTSKEFEENTQDLLDHLSIIYVATDKSESSDDSAVNMYILHSGNSLIWIQDVRHFSQRDVLSLQFEPVLLPTSTTNFTKIASFTCKAPSCESGAREDGKKKDTPTLKACLSSPVVQGYFRMDPSATQFHIENHENTSGLWSLWYLNHFDHGVVLNDVFVSKETKHVLKILNFTGPLFLPPGCWKIFSLKLAVKDIAINVFTHVFLTTNIGAVFAIPLQIYSAPTKEGSLGFEVIAHCGMHYFMGKSKAENPDWEGSLSLDPSTWDVDSELANTLYERWKKLKHGDVCKRTVLGVTRFAHSKKSKESEPFAVFLPRLVPEPGLVLNFSATALRNSMVKYFVVKNPSSWPVSLQLLPVSLYPKPEAAARLLHKWFGTDMQMINLTTSEFQLTKACPYLGVRSEGSRFGILHLHLQPLERKRVGVVFTPADYGKVSSLILIRNNLTVIDMIGVEGFGARELLKVGGRLPGTGGSLRFKVPESTLMDCRRQLKDSKQILSITKNFKVENIGPLPITVTSLKINGYNCQGYGFEVLDCHQFSLGPNTSRDISIVFTPDFTSSWVIRELTLVTAADLEFRFTLNVTLPHHLLPLCADVVPGPSWEESFWRLTVFFVSLSLLGVILIAFQQAQYILMEFMKTRQRQNASSSSQQSTAPVDVISAHSHKSNCKNFLDAYAPSDKGRGKSCLPVSSPQSRTQNATKRSPATCGHSQKKHKCSVYYGRHRGAAVASSAGAPSEDRPAPAKAGGCPAGAGEAWVGLRCAGGLSANLQKSLALPRSFLGKDENTLKSAVAASSPSSECHVKEGAQTCVFPKETDFQVSESVAELKEREVCPMKTPKKLPENHLPRSSPQCQSDLPDISRKNNGNNQQVPVKNEVDNCESLKKVDTKSSSEKKIHKAAKEDGCSEKQDIPSIEQEDPYRKKALQEKKEGNVQNLNWNKNRMCRKNKKRGAAQVLRPSDQSELKLVCSEFERSELSSDINVRNWRIQENPGEACKAGASSGSSLPATQGEAEGYFQKPGKKGAEKSCSDSGSDCGSSSGSVRASRGSWGSWSSASSSDGDRKPAVGPPRCLLPGDSVSQNDFSSEAPISLNLSRNICNPTDVSGLPAPADAPCPSLPAGPAAAEEQGLCAPGDLWPAQPVCVTGGFGCALESGGPAALPPPAAVPSSSFIDWNATCEGQFPSVYCPLELNDYNAFPEEGMNYPSGFPCPAEVQTDFIDHSSPSAWGSPPSVPTAWGHASLISSPPYLTSTRSLSPMSGLFGSIWAPQSDVYENCCAINPTTEHSAHMENQAVMCKEYYPGFNPFRAYMDLDIWTSTANRNANFPLSRDSSYCGNV

Protein

Transmembrane protein 131-like: TMEM131L

Gene

Tmem131l

Protein

Transmembrane protein 131-like

Organism

Mus musculus

Length

1597 amino acids

Function

In its membrane-associated form, antagonizes canonical Wnt signaling by triggering lysosome-dependent degradation of Wnt-activated LRP6. Regulates thymocyte proliferation.

Similarity

Belongs to the TMEM131 family.

Mass

175.772 kDa

Sequence

MAGLRRPQSGAYRRTAAAVNLLLGVFQVLLSCCRPGGAQGQAFEPLPNVVELWQAEEGELLLPTQGDSEEDMEEPSQEQSFSDKLFIGKGLHFQPSVLDFGIQFLGHPAAKLLYAYNPSRESEVVVNSVFTAARHFHVPPVHCRVIPAMGKASFRVIFLPTEEGSIESSLFINTSSHGVFSYHVSGVGTRRVSTEGSAEQLPNAYFLLPQVQSIQLSQTQAETTNTSLLRVQLECSLHNKVCQQLKSCSLGSDDALHLEMNIIVAVENSSKQPEENTQALLDHLSIVYVATDESDTSDESAVNMYVLHSGNSLIWIQDIHHFSQKNVLSLQFEPVLLSTSTTNFTKIASFTCKAGTSCDSGIMGLRKKKASPAMQACLSSPVVQGYFRTDASTAQFHIESHETATGVWSIWYRSHFDQSIVLKDVFVSKETKHILKVLSFRGPLFLPPGCWNIFSLKLAVKGIVLNLFTNVFLTTNTGAIFAIPLQIFSAPTKEGSLGFEVLAHCGMHYFMGKSKTENPNWERSLSLDRSTWDMDSELANKLYERWKKYKSGDACRRNVLGMSQFAFTKKSKETEPFVSFLPRVVPEPNLVLNFSATALRNSAVKYFVVRNPTPQPVSLQLLPLSLYPRPEAAVRLLHKWFGTDMQMVNLSTGEFQLTQACPYQGEPSEESSLGALHVHLQALETRRVGVVFTPADYGKVTSLILIRNNLTVVDMVGVEGFGAQELLKVGGRLPGAGGSLRFKVPESTLMDCHRQLKDSKQILSITKNFKVENIGPLPITVTSLKINGYNCQGYGFEVLDCHPFSLSPNTSRDISIVFTPDFTSSWVIRELTLVTAADLEFHFTLNVTLPHHMLPLCAEVVPGPSWEESFWRLTVFFVSLSLLGVILIAFQQAQYILMEFMKTRQRQNGSSSSQQNGDPVAMISSHPHKSTCKNFLDTYSPSDKGRGKSCLPVGPSLSRLQNAAKRSPATYGHSQKKHKCSFYYSKQKPSASAASSANVTTEEKQTVTLASSLSVAKEDICTNVLSENWVSLRYASGINGSLQKNLTLPKNVLHKEESSLKNTVVTNTPSECSMKEGVHTYMFPKETDSKISENVAELKEQEPCPQKTSKKPPESTLPKTPPQYLQSDLPEVSRKHGNKQQAPVRSEVDSFEPVRAADAEPSSVRKTQGASPEDTCSEKQDTPSAEQEDPSRKRKLQERREGSTQALNWNKTRPCRRNKKRASAQASSSPRPSEQSEQRLVCSDVRSWCAQDGAGEKCKAGTEVSGSSPERREEDSYYQKSEKKCADKFCSDSSSDCGSSSGSVRASRGSWGSWSSSSSDCDRRPVVDIQHFLPPGDGVSPQNFPSEASVPLSLPQHVCSSTDVSVLPEFTESPCPGLPATPAGAGEEKGLYPPGGLWPSQPVCLTSSFNCPVENGAPGVSQEPTSIPDSSFIDWSASCEGQFPSVYCPLELNDYNAFPEENMNYTNGFPCSSKVQTDFIGHSTPSTWNTPASMPAAWGHASLVNSPSYLTSTRSLSPMSGLFGSIWAPQSEVYETCCPISPATEHATHMENQVMCKEYYLGFNPFRAYMNLDIWTSTANRNANFPLSRDSSYCGNM

Protein

Transmembrane protein 131-like: Tmem131l