TMC2

Gene

TMC2

Protein

Transmembrane channel-like protein 2

Organism

Homo sapiens

Length

906 amino acids

Function

Probable ion channel required for the normal function of cochlear hair cells (PubMed:11850618). Component of the hair cell's mechanotransduction (MET) machinery. Involved in mechanosensitive responses of the hair cells (By similarity).

Similarity

Belongs to the TMC family.

Mass

102.61 kDa

Sequence

MSHQVKGLKEEARGGVKGRVKSGSPHTGDRLGRRSSSKRALKAEGTPGRRGAQRSQKERAGGSPSPGSPRRKQTGRRRHREELGEQERGEAERTCEGRRKRDERASFQERTAAPKREKEIPRREEKSKRQKKPRSSSLASSASGGESLSEEELAQILEQVEEKKKLIATMRSKPWPMAKKLTELREAQEFVEKYEGALGKGKGKQLYAYKMLMAKKWVKFKRDFDNFKTQCIPWEMKIKDIESHFGSSVASYFIFLRWMYGVNLVLFGLIFGLVIIPEVLMGMPYGSIPRKTVPRAEEEKAMDFSVLWDFEGYIKYSALFYGYYNNQRTIGWLRYRLPMAYFMVGVSVFGYSLIIVIRSMASNTQGSTGEGESDNFTFSFKMFTSWDYLIGNSETADNKYASITTSFKESIVDEQESNKEENIHLTRFLRVLANFLIICCLCGSGYLIYFVVKRSQQFSKMQNVSWYERNEVEIVMSLLGMFCPPLFETIAALENYHPRTGLKWQLGRIFALFLGNLYTFLLALMDDVHLKLANEETIKNITHWTLFNYYNSSGWNESVPRPPLHPADVPRGSCWETAVGIEFMRLTVSDMLVTYITILLGDFLRACFVRFMNYCWCWDLEAGFPSYAEFDISGNVLGLIFNQGMIWMGSFYAPGLVGINVLRLLTSMYFQCWAVMSSNVPHERVFKASRSNNFYMGLLLLVLFLSLLPVAYTIMSLPPSFDCGPFSGKNRMYDVLQETIENDFPTFLGKIFAFLANPGLIIPAILLMFLAIYYLNSVSKSLSRANAQLRKKIQVLREVEKSHKSVKGKATARDSEDTPKSSSKNATQLQLTKEETTPPSASQSQAMDKKAQGPGTSNSASRTTLPASGHLPISRPPGIGPDSGHAPSQTHPWRSASGKSAQRPPH

Protein

Transmembrane channel-like protein 2: TMC2

Gene

Tmc2

Protein

Transmembrane channel-like protein 2

Organism

Mus musculus

Length

888 amino acids

Function

Probable ion channel required for the normal function of cochlear hair cells (By similarity). Component of the hair cell's mechanotransduction (MET) machinery. Involved in mechanosensitive responses of the hair cells (By similarity).

Similarity

Belongs to the TMC family.

Mass

101.134 kDa

Sequence

MSPQLKSLDEEGDKSARRPTRKQTSRAACPQDGHRAQSSRKDPAKGSPRPGSSRKKQMEHGSYHKGLQGQKPRKVERSLQGRKKDRRTSLKEQRASPKKEREALRKEAGKQLRKPRSTSLGSSVSTGDSLSEEELAQILEQVEEKKKLITTVRNKPWPMAKKLRELREAQAFVEKYEGALGKGKGKHLYAYRMMMAKKWVKFKRDFDNFKTQCIPWEMKIKDIESHFGSSVASYFIFLRWMYGVNLVLFGLIFGLVIIPEVLMGMPYGSIPRKTVPRAEEERAMDFSVLWDFEGYIKYSALFYGYYNNQRTIGWLRYRLPMAYFMVGVSVFGYSLMIVIRSMASNTQGSTSEGDSDSFTFSFKMFTSWDYLIGNSETADNKYVSITTSFKESIVDEQESNKEGNIHLTRFLRVLANFLILCCLCGSGYLIYFVVKRSQEFSKMQNVSWYERNEVEIVMSLLGMFCPPLFETIAALENYHPRTGLKWQLGRIFALFLGNLYTFLLALMDDVHLKLSNEEKIKNITHWTLFNYYNSSGGNESVPRPPPHPADVPRGSCWETAVGIEFMRLTVSDMLVTYLTILVGDFLRACFVRFMNHCWCWDLEAGFPSYAEFDISGNVLGLIFNQGMIWMGSFYAPGLVGINVLRLLTSMYFQCWAVMSSNVPHERVFKASRSNNFYMGLLLLVLFLSLLPVAYTVMSLPPSFDCGPFSGKNRMYDVLHETIENDFPKFLGKIFAFLANPGLIIPAILLMFLAIYYLNSVSKSLSRANAQLRKKIQALREVEKNHKSIKGKAIVTYSEDTIKNSSKNATQIHLTKEEPTSHSSSQIQTLDKKAQGPHTSSTEGGASPSTSWHHVGSQPPRGRRDSGQPQSQTYTGRSPSGKRTQRPHN

Protein

Transmembrane channel-like protein 2: Tmc2