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TIMP4

Gene
TIMP4
Protein
Metalloproteinase inhibitor 4
Organism
Bos taurus
Length
224 amino acids
Function
Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor.
Similarity
Belongs to the protease inhibitor I35 (TIMP) family.
Mass
25.593 kDa
Sequence
MPQSPRPVPSWALLLRLLALLRPPGLGEACSCAPAHPQQHVCHSALAIRAKISSEKVVPASTDPADPQKMIRYEIKQIKMFKGFEKVNDIQYIYTPFDSSLCGVKLEANSQKRYLLTGQILSDGKVFVHLCNYIEPWENLSFLQRESLNHHYHLNCGCQITTCYAVPCTISAPNECLWTDWLLERKLYGYQAQHYVCMKHVDGSCSWYQGRLPLRKEFVDIIQP

Gene
TIMP4
Protein
Metalloproteinase inhibitor 4
Organism
Homo sapiens
Length
224 amino acids
Function
Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7 and MMP-9.
Similarity
Belongs to the protease inhibitor I35 (TIMP) family.
Mass
25.503 kDa
Sequence
MPGSPRPAPSWVLLLRLLALLRPPGLGEACSCAPAHPQQHICHSALVIRAKISSEKVVPASADPADTEKMLRYEIKQIKMFKGFEKVKDVQYIYTPFDSSLCGVKLEANSQKQYLLTGQVLSDGKVFIHLCNYIEPWEDLSLVQRESLNHHYHLNCGCQITTCYTVPCTISAPNECLWTDWLLERKLYGYQAQHYVCMKHVDGTCSWYRGHLPLRKEFVDIVQP

Gene
Timp4
Protein
Metalloproteinase inhibitor 4
Organism
Mus musculus
Length
224 amino acids
Function
Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor.
Similarity
Belongs to the protease inhibitor I35 (TIMP) family.
Mass
25.774 kDa
Sequence
MPWSPLAALSWALVLRLLALLWPPGRGEACSCAPAHPQQHFCHSALVIRAKISSEKVVPASKDPADTQKLIRYEIKQIKMFKGFEKAKDIQYVYTPFDSSLCGVKLETNSHKQYLLTGQILSDGKVFIHLCNYIEPWEDLSLVQRESLNHHYHQNCGCQITTCYAVPCTISAPNECLWTDWLLERKLYGYQAQHYVCMKHVDGICSWYRGHLHLRKEYVDIIQP

Gene
Timp4
Protein
Metalloproteinase inhibitor 4
Organism
Rattus norvegicus
Length
224 amino acids
Function
Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor.
Similarity
Belongs to the protease inhibitor I35 (TIMP) family.
Mass
25.723 kDa
Sequence
MPWSPLAALSWALVLRLLALLWPPGRGEACSCAPAHPQQHVCHSALVIRAKISSEKVVPASEDPADTQKMIRYEIKQIKMFKGFEKAKDIQYVYTPFDSSLCGVKLETNSQKQYLLTGQILSDGKVFIHLCNYIEPWEDLSLVQRESLNHHYHQNCGCQITTCYAVPCTISAPDECLWTDWLLERKLYGYQAQHYVCMKHVDGICSWYRGHLHLRKEYVDIVQP

Gene
TIMP4
Protein
Metalloproteinase inhibitor 4
Organism
Oryctolagus cuniculus
Length
170 amino acids
Function
Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor.
Similarity
Belongs to the protease inhibitor I35 (TIMP) family.
Mass
19.811 kDa
Fragment
single
Sequence
ISSEKVVPASADPADTQRMIRYEIKQIKMFKGFEKIKDVQYIYTPFDSSLCGVKLEANSQKQYLLTGQVLSDGKVFIHLCNYIEPWEDLSLVQRESLNHHYHLNCVCQITTCYTVPCTISAPNECLWTDWLLERKLYGYQAQHYVCMKHADGTCSWYQGRLPLRKEFVDI