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THPO

Gene
Thpo
Protein
Thrombopoietin
Organism
Mus musculus
Length
356 amino acids
Function
Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets.
Similarity
Belongs to the EPO/TPO family.
Mass
37.836 kDa
Sequence
MELTDLLLAAMLLAVARLTLSSPVAPACDPRLLNKLLRDSHLLHSRLSQCPDVDPLSIPVLLPAVDFSLGEWKTQTEQSKAQDILGAVSLLLEGVMAARGQLEPSCLSSLLGQLSGQVRLLLGALQGLLGTQLPLQGRTTAHKDPNALFLSLQQLLRGKVRFLLLVEGPTLCVRRTLPTTAVPSSTSQLLTLNKFPNRTSGLLETNFSVTARTAGPGLLSRLQGFRVKITPGQLNQTSRSPVQISGYLNRTHGPVNGTHGLFAGTSLQTLEASDISPGAFNKGSLAFNLQGGLPPSPSLAPDGHTPFPPSPALPTTHGSPPQLHPLFPDPSTTMPNSTAPHPVTMYPHPRNLSQET

Gene
THPO
Protein
Thrombopoietin
Organism
Homo sapiens
Length
353 amino acids
Function
Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets.
Similarity
Belongs to the EPO/TPO family.
Mass
37.823 kDa
Sequence
MELTELLLVVMLLLTARLTLSSPAPPACDLRVLSKLLRDSHVLHSRLSQCPEVHPLPTPVLLPAVDFSLGEWKTQMEETKAQDILGAVTLLLEGVMAARGQLGPTCLSSLLGQLSGQVRLLLGALQSLLGTQLPPQGRTTAHKDPNAIFLSFQHLLRGKVRFLMLVGGSTLCVRRAPPTTAVPSRTSLVLTLNELPNRTSGLLETNFTASARTTGSGLLKWQQGFRAKIPGLLNQTSRSLDQIPGYLNRIHELLNGTRGLFPGPSRRTLGAPDISSGTSDTGSLPPNLQPGYSPSPTHPPTGQYTLFPLPPTLPTPVVQLHPLLPDPSAPTPTPTSPLLNTSYTHSQNLSQEG

Gene
THPO
Protein
Thrombopoietin
Organism
Canis lupus familiaris
Length
352 amino acids
Function
Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets.
Similarity
Belongs to the EPO/TPO family.
Mass
37.642 kDa
Sequence
MELTELLLVVMLLLTARLDPCLPAPPACDPRLLNKMLRDSHVLHSRLSQCPDIYPLSTPVLLPAVDFSLGEWKTQKEQTKAQDVWGAVALLLDGVLAARGQLGPSCLSSLLGQLSGQVRLLLGALQGLLGTQLPPQGRTTTHKDPNAIFLSFQQLLRGKVRFLLLVAGPTLCAKQSQPTTAVPTNTSLFLTLRKLPNRTSGLLETNSSISARTTGSGLLKRLQGFRAKIPGLLNQTSRSLNQTPGHLSRTHGPLNGTHGLLPGLSLTALGAPDIPPGTSDMDALPPNLWPRYSPSPIHPPPGQYTLFSPLPTSPTPQNPLQPPPPDPSATANSTSPLLIAAHPHFQNLSQEE

Gene
Thpo
Protein
Thrombopoietin
Organism
Rattus norvegicus
Length
326 amino acids
Function
Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets.
Similarity
Belongs to the EPO/TPO family.
Mass
34.556 kDa
Sequence
MELTDLLLVAILLLTARLTLSSPVPPACDPRLLNKLLRDSYLLHSRLSQCPDVNPLSIPVLLPAVDFSLGEWKTQTEQSKAQDILGAVSLLLEGVMAARGQLEPSCLSSLLGQLSGQVRLLLGALQGLLGTQLPPQGRTTAHKDPSALFLSLQQLLRGKVRFLLLVEGPALCVRRTLPTTAVPSRTSQLLTLNKFPNRTSGLLETNFSVVARTAGPGLLNRLQGFRAKIIPGQLNQTSGSLDQIPGYLNGTHEPVNGTHGLFAGTSLQTLEAPDVVPGAFNKGSLPLNLQSGLPPIPSLAADGYTLFPPSPTFPTPGSPPQLPPVS

Gene
THPO
Protein
Thrombopoietin
Organism
Sus scrofa
Length
26 amino acids
Function
Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets.
Similarity
Belongs to the EPO/TPO family.
Mass
2.904 kDa
Fragment
single
Sequence
SPAPPACDPRLLNKLLRDDHVLHGRL