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THI1-4

Gene
THI1-4
Protein
Thiamine thiazole synthase 4, chloroplastic
Organism
Physcomitrella patens subsp. patens
Length
343 amino acids
Function
Involved in biosynthesis of the thiamine precursor thiazole. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid (ADT), an adenylated thiazole intermediate. The reaction includes an iron-dependent sulfide transfer from a conserved cysteine residue of the protein to a thiazole intermediate. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. May have additional roles in adaptation to various stress conditions and in DNA damage tolerance.
Similarity
Belongs to the THI4 family.
Mass
36.632 kDa
Sequence
MSSQAGNVGSSSSSLAGVRMVVSPKAQLRHARLPAASASMYSDAKYDLNNYKFEPIKESIVAREMTRRYMTEMITHADTDVVVVGAGSAGLSCAYELSKNPNVKVAIIEQSVSPGGGAWLGGQLFSAMVVRKPAHRFLDEIEVPYEELENYVVIKHAALFTSTIMSKLLARPNVKLFNAVAAEDLIIRGDRVSGVVTNWALVAQNHNTQSCMDPNVMEAKVVVSSCGHDGPFGATGVKRLRSIGMIESVPGMKCLDMNAAEDAIVKHTREVVPGMIVTGMEVAEIDGSPRMGPTFGAMMISGQKAAHLALKALGLPNELDGNYKLNVHPELVLASTDDETASA