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THEYE_A0977

Gene
THEYE_A0977
Protein
Probable S-methyl-5'-thioinosine phosphorylase
Organism
Thermodesulfovibrio yellowstonii (strain ATCC 51303 / DSM 11347 / YP87)
Length
265 amino acids
Function
Catalyzes the reversible phosphorylation of S-methyl-5'-thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine.
Similarity
Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
Mass
29.62 kDa
Sequence
MHNKQQVKIGIIGGSGLSESEAKKEIITIKTPYGEPSCPYEIEKIDDIEVLFLRRHGQKHSIPPHKVNYRANIYGFKNFGIERIFGVFATGSLTENIPPGSIVIPNQIIDFTQGMRANTFYEEKKVVHIDFTEPFCSEIRHYLLETARKIGINVISHATYICVNGPRLETAAEIKFFKNIGADIIGMTIMPEASLAREVEICYAAVAVVANYAAGISKFPLTVKEVIETMEDSLDAVGFLIKETIKKLPEERKCLCKHALKNASF