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THEM4

Gene
THEM4
Protein
Acyl-coenzyme A thioesterase THEM4
Organism
Homo sapiens
Length
240 amino acids
Function
Has acyl-CoA thioesterase activity towards medium and long-chain (C14 to C18) fatty acyl-CoA substrates, and probably plays a role in mitochondrial fatty acid metabolism. Plays a role in the apoptotic process, possibly via its regulation of AKT1 activity. According to PubMed:11598301, inhibits AKT1 phosphorylation and activity. According to PubMed:17615157, enhances AKT1 activity by favoring its phosphorylation and translocation to plasma membrane.
Similarity
Belongs to the THEM4/THEM5 thioesterase family.
Mass
27.13 kDa
Sequence
MLRSCAARLRTLGALCLPPVGRRLPGSEPRPELRSFSSEEVILKDCSVPNPSWNKDLRLLFDQFMKKCEDGSWKRLPSYKRTPTEWIQDFKTHFLDPKLMKEEQMSQAQLFTRSFDDGLGFEYVMFYNDIEKRMVCLFQGGPYLEGPPGFIHGGAIATMIDATVGMCAMMAGGIVMTANLNINYKRPIPLCSVVMINSQLDKVEGRKFFVSCNVQSVDEKTLYSEATSLFIKLNPAKSLT

Gene
THEM4
Protein
Acyl-coenzyme A thioesterase THEM4
Organism
Bos taurus
Length
237 amino acids
Function
Has acyl-CoA thioesterase activity towards medium and long-chain (C14 to C18) fatty acyl-CoA substrates, and probably plays a role in mitochondrial fatty acid metabolism (By similarity). Plays a role in the apoptotic process, possibly via its regulation of AKT1 activity (By similarity).
Similarity
Belongs to the THEM4/THEM5 thioesterase family.
Mass
26.812 kDa
Sequence
MLRSCTAGLRSIWALRGRREGAPRLSMDLQPARRLFSTEKVIHKDWALPNPSWSKDLKLLFDQFMKKCEDGSWERLPSYKRRSTQESEDFKTYFLDPKLVEEERLSQAQLFTRGFEDGLGFEYVIFKNNDEKRTVCLFQGGPYLQGVPGLLHGGAMATMIDIALGSCTGGAVMTANLNINFKRPVPLCSVVVINSQLDKLEGRKLFLSCNVRSVDEKTLYSEATGLFIKLDPEKSST

Gene
Them4
Protein
Acyl-coenzyme A thioesterase THEM4
Organism
Mus musculus
Length
230 amino acids
Function
Has acyl-CoA thioesterase activity towards medium and long-chain (C14 to C18) fatty acyl-CoA substrates, and probably plays a role in mitochondrial fatty acid metabolism (By similarity). Plays a role in the apoptotic process, possibly via its regulation of AKT1 activity (PubMed:19421406).
Similarity
Belongs to the THEM4/THEM5 thioesterase family.
Mass
26.031 kDa
Sequence
MLRNCAMRLRTLGATPARRPGAARRLFSSEKVIRKDYALPNPSWTKDLRLLFDQFMKKCEDGSWKRMPSHRQNPTRAIQEFQTLFVDSKFKKEEQMSKAQQFTRSFEEGLGFEYAMFYNKVEKRTVSLFQGGLHLQGVPGFVHGGAIATIIDVTTGTCAISEGVAMTANLNITYKKPIPLLSVVVVNSQLQKIEGRKLFVSCTIQSIDEKTLYTEATALFIKLDPEKPLT

Gene
Them4
Protein
Acyl-coenzyme A thioesterase THEM4
Organism
Rattus norvegicus
Length
230 amino acids
Function
Has acyl-CoA thioesterase activity towards medium and long-chain (C14 to C18) fatty acyl-CoA substrates, and probably plays a role in mitochondrial fatty acid metabolism (By similarity). Plays a role in the apoptotic process, possibly via its regulation of AKT1 activity (By similarity).
Similarity
Belongs to the THEM4/THEM5 thioesterase family.
Mass
26.089 kDa
Sequence
MLRSCAMRLRTLGATPARRPEATRRLFSSEEVVCKDYALPNPSWTKDLRLLFDQFMKKCEDGSWKRLPSYRQNPPQALQEFQTHFVDSKFKKEEQMSKAQQFTRSLEEGLGFEYAMFYNKAEKRIVCLFQGGLHLQGMPGFVHGGAIATIIDITAGMCAFSEGIVMTANLNIDYKKPIPLLSVVVVNSQLQKIEGRKLFVSCTIQSTDEKTLHTQATALFIKLDPDKPLT

Gene
them4
Protein
Acyl-coenzyme A thioesterase THEM4
Organism
Xenopus laevis
Length
222 amino acids
Function
Has acyl-CoA thioesterase activity towards medium and long-chain (C14 to C18) fatty acyl-CoA substrates, and probably plays a role in mitochondrial fatty acid metabolism.
Similarity
Belongs to the THEM4/THEM5 thioesterase family.
Mass
24.981 kDa
Sequence
MLRSCARLIYKGITLPRQQQNLHSLPCSYTAPKFYSQEAPRDYGVPNTTWSKNLLDLYNKYMEGSKSGTWKRIPSYNATVHYIKGVPPVRNREKRLFTRNLDQDGVGFEYCMFYNKAERRMVCLFQPGPYLEGPPGFTHGGCIATMIDSTTGAGAVYLCGGVMTANLTVDYKNPIPLGCVVIIDSKVEKIEGRKVFTSCQIRSHDDSMLHTEATALFIKLCP