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THAP1

Gene
thap1
Protein
THAP domain-containing protein 1
Organism
Salmo salar
Length
233 amino acids
Function
DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes (By similarity).
Similarity
Belongs to the THAP1 family.
Mass
27.018 kDa
Sequence
MVQSCSAYGCKNRYHKDKNISFHKFPLARPDVCGKWVAAMRRNNFKPTRYSNICSQHFTKDCFKPECNNRVLKENAVPSLFCFSKLQIKAESLADPFPPEMDFPLTLPSLPLSDTEETQQEIQTETHHTVDPLPLVENLPHSMSISCDHNYTVEDTVQQKKRIEQLEEQLDKLRKKLKTVQQKCRRQERQLKRFKAIGEFQRVNRDPALGEGYVILPKQLYDALKGIEPVEGP

Gene
thap1
Protein
THAP domain-containing protein 1
Organism
Danio rerio
Length
225 amino acids
Function
DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes (By similarity).
Similarity
Belongs to the THAP1 family.
Mass
25.707 kDa
Sequence
MVQSCSAYGCKNRYQKDRNISFHKFPLARPEVCVQWVSAMSRRNFKPTKYSNICSQHFTSDCFKQECNNRVLKDNAVPSLFTLQTQDPFSADVCFPLNVCATAEPLSECFPEQCGLPDGQEAGAVSCPEQCVPPGGQEAGAVSCDHNYTLEDCVQQKRRVQRLQEQMEKLRRRMKTLQQKCRRQERQLERLRANRGPAPLGDRYVILPRELYEELQGVETIGAVH

Gene
thap1
Protein
THAP domain-containing protein 1
Organism
Xenopus tropicalis
Length
225 amino acids
Function
DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes (By similarity).
Similarity
Belongs to the THAP1 family.
Mass
26.168 kDa
Sequence
MVQSCSAYGCKNRYDKDKPISFHKFPLKRPLLCRKWEAAVRRADFKPTKYSSICSDHFTADCFKRECNNKLLKDNAVPTIFAHTEIKKKSGKAVKKEQLPAEPEPVPSVPEVDPAIGLLLPPLYTPSHIAVICDHNYTVEDTVHQRRRIQQLEEQVDKLRKKLKIANQKCRRQERSLEKLEREVSEYREAKGSGYVIFPGNYYEVLNENEYKELAPEITYKEIIL

Gene
THAP1
Protein
THAP domain-containing protein 1
Organism
Bos taurus
Length
213 amino acids
Function
DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes, including RRM1. May also have pro-apoptopic activity by potentiating both serum-withdrawal and TNF-induced apoptosis (By similarity).
Similarity
Belongs to the THAP1 family.
Mass
24.876 kDa
Sequence
MVQSCSAYGCKNRYDKDKPVSFHKFPLTRPSLCKKWEAAVRRKNFKPTKYSSICSEHFTPDCFKRECNNKLLKEDAVPTIFLCTEPHDKKEDLLEPQEQPPPPPLTPPISQVDAAIGLLMPPLQTPDNLSVFCDHNYTVEDTMHQRKRIHQLEQQVEKLRKKLKTAQQRCRRQERQLEKLKEVVHFQKEKDGASERGYVILPNDYFEIVEVPA

Gene
THAP1
Protein
THAP domain-containing protein 1
Organism
Homo sapiens
Length
213 amino acids
Function
DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes, including RRM1. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. May also have pro-apoptopic activity by potentiating both serum-withdrawal and TNF-induced apoptosis.
Similarity
Belongs to the THAP1 family.
Mass
24.944 kDa
Sequence
MVQSCSAYGCKNRYDKDKPVSFHKFPLTRPSLCKEWEAAVRRKNFKPTKYSSICSEHFTPDCFKRECNNKLLKENAVPTIFLCTEPHDKKEDLLEPQEQLPPPPLPPPVSQVDAAIGLLMPPLQTPVNLSVFCDHNYTVEDTMHQRKRIHQLEQQVEKLRKKLKTAQQRCRRQERQLEKLKEVVHFQKEKDDVSERGYVILPNDYFEIVEVPA

Gene
THAP1
Protein
THAP domain-containing protein 1
Organism
Pongo abelii
Length
213 amino acids
Function
DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes, including RRM1. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. May also have pro-apoptopic activity by potentiating both serum-withdrawal and TNF-induced apoptosis (By similarity).
Similarity
Belongs to the THAP1 family.
Mass
24.944 kDa
Sequence
MVQSCSAYGCKNRYDKDKPVSFHKFPLTRPSLCKEWEAAVRRKNFKPTKYSSICSEHFTPDCFKRECNNKLLKENAVPTIFLCTEPHDKKEDLLEPQEQLPPPPLPPPVSQVDAAIGLLMPPLQTPVNLSVFCDHNYTVEDTMHQRKRIHQLEQQVEKLRKKLKTAQQRCRRQERQLEKLKEVVHFQKEKDDVSERGYVILPNDYFEIVEVPA

Gene
THAP1
Protein
THAP domain-containing protein 1
Organism
Macaca fascicularis
Length
212 amino acids
Function
DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes, including RRM1. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. May also have pro-apoptopic activity by potentiating both serum-withdrawal and TNF-induced apoptosis (By similarity).
Similarity
Belongs to the THAP1 family.
Mass
24.84 kDa
Sequence
MVQPCSAYGCKNRYDKDKPVSFHKFPLTRPSLCKEWEAAVRRKNFKPTKYSSICSEHFTPDCFKRECNNKLLKENAVPTIFLCTEPHDKKEDLEPQEQLPPPPLPPPVSQVDAAIGLLMPPLQTPVNLSVFCDHNYTVEDTMHQRKRIHQLEQQVEKLRKKLKTAQQRCRRQERQLEKLKEVVHFQKEKDNVSERGYVILPNDYFEIVEVPA

Gene
Thap1
Protein
THAP domain-containing protein 1
Organism
Mus musculus
Length
210 amino acids
Function
DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes, including RRM1. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. May also have pro-apoptopic activity by potentiating both serum-withdrawal and TNF-induced apoptosis (By similarity).
Similarity
Belongs to the THAP1 family.
Mass
24.611 kDa
Sequence
MVQSCSAYGCKNRYDKDKPVSFHKFPLTRPSLCKQWEAAVKRKNFKPTKYSSICSEHFTPDCFKRECNNKLLKENAVPTIFLYIEPHEKKEDLESQEQLPSPSPPASQVDAAIGLLMPPLQTPDNLSVFCDHNYTVEDTMHQRKRILQLEQQVEKLRKKLKTAQQRCRRQERQLEKLKEVVHFQREKDDASERGYVILPNDYFEIVEVPA

Gene
Thap1
Protein
THAP domain-containing protein 1
Organism
Rattus norvegicus
Length
210 amino acids
Function
DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes, including RRM1. May also have pro-apoptopic activity by potentiating both serum-withdrawal and TNF-induced apoptosis (By similarity).
Similarity
Belongs to the THAP1 family.
Mass
24.688 kDa
Sequence
MVQSCSAYGCKNRYDKDKPVSFHKFPLTRPSLCKQWEAAVRRKNFKPTKYSSICSEHFTPDCFKRECNNKLLKENAVPTIFLYIEPHEKKEELEPQEQLPSPSPPTSQVDAAVGLLMPPLQTPDNLSVFCDHNYTVEDTMHQRKRILHLEQQVEKLRKKLKTAQQRCRRQERQLEKLKEVVHFQREKDDASERGYVILPNDYFEIVEVPA