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TGFB1I1

Gene
tgfb1i1
Protein
Transforming growth factor beta-1-induced transcript 1 protein
Organism
Xenopus laevis
Length
506 amino acids
Function
Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. May regulate both Wnt and steroid signaling pathways and play a role in the processes of cell growth, proliferation, migration, differentiation and senescence. May have a zinc-dependent DNA-binding activity.
Similarity
Belongs to the paxillin family.
Mass
56.001 kDa
Sequence
MEDLDALLADLQITTPPRCPVLLTDSPEKPQPTETRPPPPPYDPKTAMSNKTSDHETFPVDKDHLYSTVQKYPLPSVSPALGGGLCELDRLLNELNATQFNITDEIMSQFPTRDPSEQKAEAQKEAEKRALSASSATLELDRLMASLSDFHKQNTVSQEVEAPGAYKGSEEVSRPGDTEDLSSPRSTACVPKDLEDAPTPKSFKVVSAPGHLEVKTNQVNSDEVTASRVPDSVSGSKVPEATSVPRSDLDSMLVKLQSGLKQQGIETYSKGLCESCQRPIAGQVVTALGHTWHPEHFVCAHCHTLIGTSNFFEKDGRPYCEKDYFMLYAPRCALCELPIVQNMVTALGCTWHPEHFCCKVCKKPIGEEGFHEKDGEQYCSDDYFRLFGAVCAGCTEAVKESYISALGGLWHPQCFVCHVCHTPFINGSFFEHEGLPLCETHYHSRRGSLCAGCEQPITGRCVTAMGKKFHPQHLNCTFCLRQLNKGTFREHDEKPYCQACYARLYG

Gene
TGFB1I1
Protein
Transforming growth factor beta-1-induced transcript 1 protein
Organism
Homo sapiens
Length
461 amino acids
Function
Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. May also regulate SLC6A3 and SLC6A4 targeting to the plasma membrane hence regulating their activity. In the nucleus, functions as a nuclear receptor coactivator regulating glucocorticoid, androgen, mineralocorticoid and progesterone receptor transcriptional activity. May play a role in the processes of cell growth, proliferation, migration, differentiation and senescence. May have a zinc-dependent DNA-binding activity.
Similarity
Belongs to the paxillin family.
Mass
49.814 kDa
Sequence
MEDLDALLSDLETTTSHMPRSGAPKERPAEPLTPPPSYGHQPQTGSGESSGASGDKDHLYSTVCKPRSPKPAAPAAPPFSSSSGVLGTGLCELDRLLQELNATQFNITDEIMSQFPSSKVASGEQKEDQSEDKKRPSLPSSPSPGLPKASATSATLELDRLMASLSDFRVQNHLPASGPTQPPVVSSTNEGSPSPPEPTGKGSLDTMLGLLQSDLSRRGVPTQAKGLCGSCNKPIAGQVVTALGRAWHPEHFVCGGCSTALGGSSFFEKDGAPFCPECYFERFSPRCGFCNQPIRHKMVTALGTHWHPEHFCCVSCGEPFGDEGFHEREGRPYCRRDFLQLFAPRCQGCQGPILDNYISALSALWHPDCFVCRECFAPFSGGSFFEHEGRPLCENHFHARRGSLCATCGLPVTGRCVSALGRRFHPDHFTCTFCLRPLTKGSFQERAGKPYCQPCFLKLFG

Gene
Tgfb1i1
Protein
Transforming growth factor beta-1-induced transcript 1 protein
Organism
Mus musculus
Length
461 amino acids
Function
Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. May also regulate SLC6A3 and SLC6A4 targeting to the plasma membrane hence regulating their activity. In the nucleus, functions as a nuclear receptor coactivator regulating glucocorticoid, androgen, mineralocorticoid and progesterone receptor transcriptional activity. May play a role in the processes of cell growth, proliferation, migration, differentiation and senescence. May have a zinc-dependent DNA-binding activity.
Similarity
Belongs to the paxillin family.
Mass
50.101 kDa
Sequence
MEDLDALLSDLETTTSHMSRLGAPKERPPETLTPPPPYGHQPQTGSGESSGTTGDKDHLYSTVCKPRSPKPVAPVAPPFSSSSGVLGNGLCELDRLLQELNATQFNITDEIMSQFPSSKMAEGEEKEDQSEDKSSPTVPPSPFPAPSKPSATSATQELDRLMASLSDFRVQNHLPASGPPQPPAASPTREGCPSPPGQTSKGSLDTMLGLLQSDLSRRGVPTQAKGLCGSCNKPIAGQVVTALGRAWHPEHFLCSGCSTTLGGSSFFEKDGAPFCPECYFERFSPRCGFCNQPIRHKMVTALGTHWHPEHFCCVSCGEPFGEEGFHEREGRPYCRRDFLQLFAPRCQGCQGPILDNYISALSALWHPDCFVCRECLAPFSGGSFFEHEGRPLCENHFHAQRGSLCATCGLPVTGRCVSALGRRFHPDHFTCTFCLRPLTKGSFQERASKPYCQPCFLKLFG

Gene
Tgfb1i1
Protein
Transforming growth factor beta-1-induced transcript 1 protein
Organism
Rattus norvegicus
Length
461 amino acids
Function
Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. May also regulate SLC6A3 and SLC6A4 targeting to the plasma membrane hence regulating their activity. In the nucleus, functions as a nuclear receptor coactivator regulating glucocorticoid, androgen, mineralocorticoid and progesterone receptor transcriptional activity. May play a role in the processes of cell growth, proliferation, migration, differentiation and senescence. May have a zinc-dependent DNA-binding activity.
Similarity
Belongs to the paxillin family.
Mass
50.123 kDa
Sequence
MEDLDALLSDLETTTSHMSRLGAPKERPPETLTPPPPYGHQPQTGSGESSGASGDKDHLYSTVCKPRSPKSVAPVAPPFSSSSGVLGNGLCELDRLLQELNATQFNITDEIMSQFPSSKMAEGEGKEDQSEDKSITTVPSSTFPAPSKPSATSATQELDRLMASLSDFRVQNHLPASGPPQPPAVSPTREGCPSPPGQTNKGSLDTMLGLLQSDLSRRGVPTQAKGLCGSCNKPIAGQVVTALGRAWHPEHFLCRGCSTTLGGSSFFEKDGAPFCPECYFERFSPRCGFCNQPIRHKMVTALGTHWHPEHFCCVSCGEPFGEEGFHEREGRPYCRRDFLQLFAPRCQGCQGPILDNYISALSALWHPDCFVCRECLAPFSGGSFFEHEGRPLCENHFHAQRGSLCATCGLPVTGRCVSALGRRFHPDHFTCTFCLRPLTKGSFQERASKPYCQPCFLKLFG

Gene
TGFB1I1
Protein
Transforming growth factor beta-1-induced transcript 1 protein
Organism
Bos taurus
Length
456 amino acids
Function
Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. May also regulate SLC6A3 and SLC6A4 targeting to the plasma membrane hence regulating their activity. In the nucleus, functions as a nuclear receptor coactivator regulating glucocorticoid, androgen, mineralocorticoid and progesterone receptor transcriptional activity. May play a role in the processes of cell growth, proliferation, migration, differentiation and senescence. May have a zinc-dependent DNA-binding activity.
Similarity
Belongs to the paxillin family.
Mass
49.452 kDa
Sequence
MEDLDALLSDLETTTSHMPRSGALKERPPEPLTSPLTQMGPGESSGASGDKDHLYSTVCKPRSPKPAAPATPPFSSSCGVLGTGLCELDRLLQELNATQFNITDEIMSQFPSSKETAGEQKEDQSEDKKRPSPPPSPSPVLPKPSATSATLELDRLMASLSDFRVQNHLPASGPTPPPVPSSMSEDTPSPPGPTSKGSLDTMLGLLQSDLSRRGVPTQAKGLCGSCNKPIAGQVVTALGRAWHPEHFVCGGCSTALGGSSFFEKDGAPFCPECYFERFSPRCGLCNQPIRHKMVTALGTHWHPEHFCCVSCGEPFGDEGFHEREGRPYCRRDFLQLFAPRCQGCQGPILDNYISALSALWHPDCFVCRECFAPFSGGSFFEHEGRPLCENHFHARRGSLCATCGLPVTGRCVSALGRRFHPDHFTCTFCLRPLTKGSFQERAGKPYCQPCFLKLFG