Tfb2m

Dimethyladenosine transferase 2, mitochondrial

397 amino acids

S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity (By similarity).

Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. KsgA subfamily.

46.021 kDa

MRGLAMRLPPRLALSVLAGRGPSCILGSGAATRKDWQERNRRSFSDLYTQPLPDCDFEESSSWTHKSRSEPTRHIACKKSARNLVRDLLEHQNPSHQLILECNPGPGILTGALLKAGARVVAFESEKMFIPHLESLRKNADGELQVVHCDFFKIDPRYQELVRPDVNSHTIFQNLGIKAVPWSAGVPIKVFGILPNKHERRLLWKILFDLYSCESIYRYGRVELNMFISEKEFRKLIATPKRPDLYQVLGVLWQVACEIKFLHMEPWSSFSVHAENGHLEKSKHSESLNLLKQNLYLVRMTPRRTLFTENLSPLNYDMFFHLVKHCFGKRNAPIIHHLRSLSTVDPINILRQIRKRPGDTAAKMYPHDFKRLFETIERSEDSVFKWIYDYCSDDSEL

TFB2M

Dimethyladenosine transferase 2, mitochondrial

396 amino acids

S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity. Compared to TFB1M, it activates transcription of mitochondrial DNA more efficiently, while it has less methyltransferase activity.

Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. KsgA subfamily.

45.349 kDa

MWIPVVGLPRRLRLSALAGAGRFCILGSEAATRKHLPARNHCGLSDSSPQLWPEPDFRNPPRKASKASLDFKRYVTDRRLAETLAQIYLGKPSRPPHLLLECNPGPGILTQALLEAGAKVVALESDKTFIPHLESLGKNLDGKLRVIHCDFFKLDPRSGGVIKPPAMSSRGLFKNLGIEAVPWTADIPLKVVGMFPSRGEKRALWKLAYDLYSCTSIYKFGRIEVNMFIGEKEFQKLMADPGNPDLYHVLSVIWQLACEIKVLHMEPWSSFDIYTRKGPLENPKRRELLDQLQQKLYLIQMIPRQNLFTKNLTPMNYNIFFHLLKHCFGRRSATVIDHLRSLTPLDARDILMQIGKQEDEKVVNMHPQDFKTLFETIERSKDCAYKWLYDETLEDR

Tfb2m

Dimethyladenosine transferase 2, mitochondrial

396 amino acids

S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity.

Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. KsgA subfamily.

45.864 kDa

MRGPAMRLPPRIALSALARGPSCILGSGAATRKDWQTRNRRGFSDFNIEPLPDSDLEESSPWTSRNRSEPTRHIACKKAARNLVRDLLEHQNPSRQIILECNPGPGILTGALLKAGARVVAFESEKTFIPHLEPLQRNMDGELQVVHCDFFKMDPRYQEVVRPDVSSQAIFQNLGIKAVPWSAGVPIKVFGILPYKHERRILWKILFDLYSCESIYRYGRVELNMFVSEKEFRKLIATPKRPDLYQVMAVLWQVACDVKFLHMEPWSSFSVHTENGHLEKSKHGESVNLLKQNLYLVRMTPRRTLFTENLSPLNYDIFFHLVKHCFGKRNAPIIRHLRSLSTVDPINILRQIRKNPGDTAARMYPHDFKKLFETIEQSEDSVFKWIYDYCPEDMEF

TFB2M

Dimethyladenosine transferase 2, mitochondrial

394 amino acids

S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity (By similarity).

Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. KsgA subfamily.

44.952 kDa

MWVPGAGIPSRLTLSAFTRAARFCVLNSGVARWKDVPAENCRGLYDFHTQLKPDVEFGKLSSRLYKSRSETKRYVTSPRVAETVVRVLRGKRKAGQLILECNPGPGVLTRALLESGARVIALESDKNFIPELKSLGNSVNGRLEVIYCDFFKLDPRNHGMVTPPVMTSDMLFQYLGVKAHPWKKGFPLKVVGILPAKTERNTLWKILHDLYSCSSVYKYGRAELNLFISEKECRKLTANPQTPALYQSLSVLGQTACGIKVLCTEPSSLFDTYAIKGELEKQRHRESLEQNLCFVQLTPHRNLFTGTLTPFNYDVFFHMLRQCFMKRNAKLIDHLPSLSPIDAVHILKQIKKKKDVRVVDMYPKDFLRLFETIECSKDDTCKWLYDEFMEDALS