Protein
Trichosetin biosynthesis cluster transcription factor TF23
Organism
Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)
Function
Transcription factor that regulates the expression of the gene cluster that mediates the biosynthesis of trichosetin, a trans-fused decalin-containing tetramic acid with antimicrobial activity (PubMed:28379186). Plays a specific role in the induction of the cluster-specific MFS transporter MFS-T and thus regulates the detoxification of the toxic trichosetin in Gibberella fujikuroi cells (PubMed:28379186).
Sequence
MEWGPGKTAQGRARLPSSRPREKPQLSCNLCGDAAHQPRVTTQDRIRHLESLVFDLMQQSSVTQGQHGGGTPFSPVGSARFPVNTAVATTGTDSGSMRSTGGGANYVVSSHWAAVLDGIAELKDHLDSEDEAVHSDVHGVESPTAEITGPQLLYGCPKPASKDEILASILSLSRPVVDRLVSRYFNSFEMSPAVLHSVEFLKEYEEFWDDPSSVSPLWLGLLFTIMCLATQFEKFRLDPGVQSPAALSMERDLQKMADAYKLRIGQCLVLGNYTKGGPYVLETLMLYIAAEVFSSTDAEIDIWILTGNTVQIALHMGYHRDPKHFKGMSSFAAEMRRRVWATLIEMDLGLSAQMGLPRMIKQWQTDTQEPSNLQDSDFDKATVEMPPSRPETELTPILYRLVKARLMTTVGYIWDFAADVRPYTYTEVERMDSKLDEARKSIPDCLKWHSFARCITDSPQIIMQKVVLETLVYRAKIILHRKFMLGPPENSADSKRIVLESALKLLDYQHMLQEESQPFCQLYQERWRVSSLVNHDFLLATSILCYYLQNTKREGMPVSESTPMDETIMVSLRRSYDIWLQSSDSSKEARKVVKALNVVLGVSNTSGTDSGLDSSMSSSVPSGCASSTINDYQSGVEIPAGLGSQFPVLDGAMMPNWATFADDLLAAPMATPSNEWQAMDAAETVDTMGSLAWPWNLQCHALAEKVNDESLD