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TES1

Gene
TES1
Protein
Cytochrome P450 monooxygenase TES1
Organism
Alternaria alternata
Length
506 amino acids
Function
Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of the phytotoxin tentoxin, an inhibitor the F1-ATPase activity of chloroplasts, resulting in chlorosis in sensitive plants (PubMed:27490569, PubMed:7881545). Tentoxin is a cyclic tetrapeptide that consists of four amino acid residues: glycine (Gly), alanine (Ala), leucine (Leu), and dehydrophenylalanine (DPhe) (PubMed:27490569, PubMed:7881545). In addition, both the Ala and DPhe residues are N-methylated (PubMed:27490569, PubMed:7881545). The nonribosomal peptide synthetase TES assembles tentoxin from the four substrate amino acids (PubMed:27490569). The adenylation domains of each of the 4 modules are responsible for the activation of Gly, Ala, Leu and DPhe, respectively (PubMed:27490569). In addition, the N-methyltransferase domains in the second and fourth modules of TES could be responsible for N-methylation of Ala and DPhe residues (PubMed:27490569). Finally, the condensation domain located in the termination module probably catalyzes the formation of the intramolecular macrocyclization and then the release of tentoxin (PubMed:27490569). The cytochrome P450 monooxygenase TES1 is predicted to be involved in the formation of DPhe (PubMed:27490569).
Similarity
Belongs to the cytochrome P450 family.
Mass
58.103 kDa
Sequence
MEPEPLDPRAIGFMRRNLAMLRQTPMSVVLAGLILLASIYFPRFMFKSQMARFPLILEHLSSEQRRARFLVGAKALYKDGSQKFRGMAYRMQTLDEQQIVLPLSALTELRKAPEEVLSFYDMFSKVVDTIKRDLTPKLTKITSKICDEVDAALDTYLPSHGKWTEINVSKTALDIIAKVSAHLFIGGDVANDPGYLECTKNFTVHLGEATRAIKVTRVWLRPFLAPRLPEVKRLLETRTKLRSYVKRVIEEREAKIKNPDWVPPDDMMQWLLDRADRQKDTLEDCTAAQVLLILGTINASMQTLIAILHTLAVTPEYVEPLREEIRNTLNSDGSIPVSAMKEFGKMDSYFKEVGMHFPVIIEPYFRRVRKGFTLSNGQYLPPGVAIVIANPLVTDSKYDTFDGFRHYKLREASAQKDKPNHRWLIANETEFRWGYDNHVCPGRFYAHNLLKIIFARIVENYDIKMPGNVEGIEARYPMVEHGNVVMEPRDKPLLLRRVKSHQGHVD

Gene
TES1
Protein
Peroxisomal acyl-coenzyme A thioester hydrolase 1
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Length
349 amino acids
Function
Acyl-coenzyme A (acyl-CoA) thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Contributes to growth on fatty acids.
Similarity
Belongs to the C/M/P thioester hydrolase family.
Mass
40.26 kDa
Sequence
MSASKMAMSNLEKILELVPLSPTSFVTKYLPAAPVGSKGTFGGTLVSQSLLASLHTVPLNFFPTSLHSYFIKGGDPRTKITYHVQNLRNGRNFIHKQVSAYQHDKLIFTSMILFAVQRSKEHDSLQHWETIPGLQGKQPDPHRYEEATSLFQKEVLDPQKLSRYASLSDRFQDATSMSKYVDAFQYGVMEYQFPKDMFYSARHTDELDYFVKVRPPITTVEHAGDESSLHKHHPYRIPKSITPENDARYNYVAFAYLSDSYLLLTIPYFHNLPLYCHSFSVSLDHTIYFHQLPHVNNWIYLKISNPRSHWDKHLVQGKYFDTQSGRIMASVSQEGYVVYGSERDIRAKF