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TENT2

Gene
tent2
Protein
Poly(A) RNA polymerase GLD2
Organism
Xenopus tropicalis
Length
528 amino acids
Function
Cytoplasmic poly(A) RNA polymerase that adds successive AMP monomers to the 3'-end of specific RNAs, forming a poly(A) tail. In contrast to the canonical nuclear poly(A) RNA polymerase, it only adds poly(A) to selected cytoplasmic mRNAs during oocyte maturation. Plays a central role during oocyte maturation by mediating polyadenylation of dormant mRNAs, which contain 5'AAUAAA-3' sequence in their 3'-UTR. In immature oocytes, polyadenylation of poly(A) tails is counteracted by the ribonuclease parn. During maturation parn is excluded from the ribonucleoprotein complex, allowing poly(A) elongation and activation of mRNAs. May not play a role in replication-dependent histone mRNA degradation (By similarity).
Similarity
Belongs to the DNA polymerase type-B-like family. GLD2 subfamily.
Mass
60.54 kDa
Sequence
MYPNSPSQGRIPLPLPCEQQQPPLEQSQEQPLQPQPLQPQQASGYLSKLPVSVAPELLSPEQFIQASINLHNNVNFARMLMNANLLAVPPVSPPPWSYRDQSPLISPASPSSSFQNRKRRSDEGNIAYDVKRQKFQSPQEQTVNHQAVPLRGDLGCSYPGSPAFPLLQSPSPPVLKGHVPNSGECWLYDHVDTTLPVAKDKLSKQILELFQALQQQVCDLKKKDICRAELQREIQQIFPQSRLYLVGSSLNGFGTRSSDADLCLVLKDEPMNQHTEARHILSLLHKHFYTRLSYIERPQFIKAKVPIVKFRDKVSGAEFDLNVNNVVGIRNTFLLRTYAYIENRVRPLVLVIKMWANYHGLNDASRGTLSSYTLVLMALHYLQTLPEPIIPSLQKKYPECFDSTMQLHLVHHAPRNIPKYLSKNETPLGDLLLGFLKYFAIEFDWSKDIISVREAKALPRSDDYEWRNKFICVEEPYDRTNTARAVYERQKFDMIRAEFLRAWVALRDNRDLYSLLPWKGIMKKMNSL

Gene
tent2
Protein
Poly(A) RNA polymerase GLD2
Organism
Danio rerio
Length
489 amino acids
Function
Cytoplasmic poly(A) RNA polymerase that adds successive AMP monomers to the 3'-end of specific RNAs, forming a poly(A) tail. In contrast to the canonical nuclear poly(A) RNA polymerase, it only adds poly(A) to selected cytoplasmic mRNAs. May not play a role in replication-dependent histone mRNA degradation (By similarity).
Similarity
Belongs to the DNA polymerase type-B-like family. GLD2 subfamily.
Mass
55.562 kDa
Sequence
MLPRPYIFSHNDGPSSHLFQHVLPHNVSQQQRIEAHLNSTNNFIGPPMNAPRFIPTYQWTPVELSDVACSPNGPMGNNRKRRIQDNSDINLKRQRFSCPSPHNQSARNSNFTSQPVTRPVTGREVTCPTCSSATFIPGGCVPSLGETCHQNAFSPSSVKDKLSQQILNLFFACEQQSDDLEKKESCRAALQTDIQKIFPCAKVFLGGSSLNGFGSRSSDADLCLVIEEGPVNHRKDAVYVLSLVRKLLYKLSYIEKPQLIRAKVPIVKFRDRISGVEFDLNFNNTVGIRNTFLLRTYAFVEKRVRPLVLVIKKWANHHCINDASRGTLSSYTLVLMVLHYLQTLPEPVIPCLQRDYPTCFDPKMDIHLVPSGPSDIPAFVSRNQSSLGDLFLGFLRYYATVFKWDKQVISVRMARTLPKSNCKEWKDKFICVEEPFNRTNTARAVHERMKFEAIKAAFIESHRLLQLRKDLNFILPKSKQMARPQTAPR

Gene
TENT2
Protein
Poly(A) RNA polymerase GLD2
Organism
Bos taurus
Length
484 amino acids
Function
Cytoplasmic poly(A) RNA polymerase that adds successive AMP monomers to the 3'-end of specific RNAs, forming a poly(A) tail. In contrast to the canonical nuclear poly(A) RNA polymerase, it only adds poly(A) to selected cytoplasmic mRNAs. Does not play a role in replication-dependent histone mRNA degradation. Adds a single nucleotide to the 3' end of specific miRNAs, monoadenylation stabilizes and prolongs the activity of some but not all miRNAs.
Similarity
Belongs to the DNA polymerase type-B-like family. GLD2 subfamily.
Mass
56.051 kDa
Sequence
MFPNSILGRPPFTPNHQQHNNFFALSPSLYSHQQLIDAQFSFHNADLSRAVSLQQLTYGNVSPIQTSTSPLFRGRKRLSDEKNLPLDGKRQRFHSPHQEPTIVNHIVPLSDERRYSMSPLFHTHYVPDIVRCVPPFREISILEPREITLPEAKDKLSQQILELFEACQQQVSDLKKKELCRTELQREIQLLFPQSRLFLVGSSLNGFGTRSSDGDLCLVVKEEPCFFQVNQKTEARHILTLVHKHFCTRLSGYIERPQLIRAKVPIVKFRDKVSCVEFDLNVNNIVGIRNTFLLRTYAYLENRVRPLVLVIKKWASHHDINDASRGTLSSYSLVLMVLHYLQTLPEPILPSIQKIYPESFSPSIQLHLVHQAPCNVPPYLSKNESNLGDLLLGFLKYYATEFDWNSQMISVREAKAIPRPDGIEWRNKYICVEEPFDGTNTARAVHEKQKFDMIKDQFLKSWHRLKNRKDLNSILPLRAAILKR

Gene
TENT2
Protein
Poly(A) RNA polymerase GLD2
Organism
Homo sapiens
Length
484 amino acids
Function
Cytoplasmic poly(A) RNA polymerase that adds successive AMP monomers to the 3'-end of specific RNAs, forming a poly(A) tail. In contrast to the canonical nuclear poly(A) RNA polymerase, it only adds poly(A) to selected cytoplasmic mRNAs (PubMed:15070731). Does not play a role in replication-dependent histone mRNA degradation (PubMed:18172165). Adds a single nucleotide to the 3' end of specific miRNAs, monoadenylation stabilizes and prolongs the activity of some but not all miRNAs (PubMed:23200856).
Similarity
Belongs to the DNA polymerase type-B-like family. GLD2 subfamily.
Mass
56.028 kDa
Sequence
MFPNSILGRPPFTPNHQQHNNFFTLSPTVYSHQQLIDAQFNFQNADLSRAVSLQQLTYGNVSPIQTSASPLFRGRKRLSDEKNLPLDGKRQRFHSPHQEPTVVNQIVPLSGERRYSMPPLFHTHYVPDIVRCVPPFREIAFLEPREITLPEAKDKLSQQILELFETCQQQISDLKKKELCRTQLQREIQLLFPQSRLFLVGSSLNGFGTRSSDGDLCLVVKEEPCFFQVNQKTEARHILTLVHKHFCTRLSGYIERPQLIRAKVPIVKFRDKVSCVEFDLNVNNIVGIRNTFLLRTYAYLENRVRPLVLVIKKWASHHQINDASRGTLSSYSLVLMVLHYLQTLPEPILPSLQKIYPESFSPAIQLHLVHQAPCNVPPYLSKNESNLGDLLLGFLKYYATEFDWNSQMISVREAKAIPRPDGIEWRNKYICVEEPFDGTNTARAVHEKQKFDMIKDQFLKSWHRLKNKRDLNSILPVRAAVLKR

Gene
Tent2
Protein
Poly(A) RNA polymerase GLD2
Organism
Mus musculus
Length
484 amino acids
Function
Cytoplasmic poly(A) RNA polymerase that adds successive AMP monomers to the 3'-end of specific RNAs, forming a poly(A) tail. In contrast to the canonical nuclear poly(A) RNA polymerase, it only adds poly(A) to selected cytoplasmic mRNAs. Does not play a role in replication-dependent histone mRNA degradation (By similarity).
Similarity
Belongs to the DNA polymerase type-B-like family. GLD2 subfamily.
Mass
55.934 kDa
Sequence
MFPNSILGRPPFTPTHQQHNNFFALSPTLYSHQQLIDAQFNFQNVDLSRAVSLQPLTYGTVSPIQTSTSPLFRGRKRISDEKAFPLDGKRQRFHSPHQEPTIINQLVPLSGDRRYSMPPLFHTHYIPDIVRCVPPLREIPLLEPREITLPEAKDKLSQQILELFETCQQQASDLKKKELCRAQLQREIQLLFPQSRLFLVGSSLNGFGARSSDGDLCLVVKEEPCFFQVNQKTEARHILTLVHKHFCTRLSGYIERPQLIRAKVPIVKFRDKVSCVEFDLNVNNTVGIRNTFLLRTYAYLENRVRPLVLVIKKWASHHDINDASRGTLSSYSLVLMVLHYLQTLPEPILPSLQKIYPESFSTSVQLHLVHHAPCNVPPYLSKNESSLGDLLLGFLKYYATEFDWNTQMISVREAKAIPRPDDMEWRNKYICVEEPFDGTNTARAVHEKQKFDMIKDQFLKSWQRLKNKRDLNSVLPLRAATLKR

Gene
Tent2
Protein
Poly(A) RNA polymerase GLD2
Organism
Rattus norvegicus
Length
484 amino acids
Function
Cytoplasmic poly(A) RNA polymerase that adds successive AMP monomers to the 3'-end of specific RNAs, forming a poly(A) tail. In contrast to the canonical nuclear poly(A) RNA polymerase, it only adds poly(A) to selected cytoplasmic mRNAs. Does not play a role in replication-dependent histone mRNA degradation. Adds a single nucleotide to the 3' end of specific miRNAs, monoadenylation stabilizes and prolongs the activity of some but not all miRNAs.
Similarity
Belongs to the DNA polymerase type-B-like family. GLD2 subfamily.
Mass
56.007 kDa
Sequence
MFPNSILGRPPFTPTHQQHNNFFALSPTLYSHQQLIDAQFNFQNVDLSRAVSLQPLTYGTVSPIQTSTSPLFRGRKRISDEKAFRLDGKRQRFHSPHQEPTIINQLVPLSGDRRYSMPPLFHTHYVPEIVRCVPPLREIPLLEPREITLPEAKDKLSQQILELFETCQQQASDLKKKELCRAQLQREIQLLFPQSRLFLVGSSLNGFGARSSDGDLCLVVKEEPCFFQVNQKTEARHILTLVHKHFCTRLSGYIERPQLIRAKVPIVKFRDKVSCVEFDLNVNNTVGIRNTFLLRTYAYLENRVRPLVLVIKKWASHHEINDASRGTLSSYSLVLMVLHYLQTLPEPILPSLQKIYPESFSTSVQLHLVHHAPCNVPPYLSKNESSLGDLLLGFLKYYATEFDWNTQMISVREAKAIPRPDDMEWRNKYICVEEPFDGTNTARAVHEKQKFDMIKDQFLKSWQRLKNKRDLNSVLPLRAATLKR