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TDC2

Gene
TDC2
Protein
Tryptophan decarboxylase TDC2
Organism
Camptotheca acuminata
Length
498 amino acids
Function
Involved in the biosynthesis of tryptamine. Supplies tryptamine for the indole moiety of camptothecin (CPT), an anti-cancer monoterpene alkaloid. Represents a key step in monoterpene indole alkaloid biosynthesis. Is specific for tryptophan, and inactive against tyrosine, phenylalanine and 3,4-dihydroxyphenylalanine (dopa).
Similarity
Belongs to the group II decarboxylase family.
Mass
55.388 kDa
Sequence
MGSIDSNYDTESAGQCRPLEPEEFRKQAHQMVDFIADYYKNIESYPVLSQVEPGYLQSRLPETAPYRPEPFESILKDVHKDIIPGVTHWLSPNFFAYFPATVSSAAFVGEMLCTCFNAVGFNWLASPAELELEMVVMDWLASMLKLPNSFTFLGTGGGVIQGTTSEAILCTLIAARDRALESIGVDSIHKLVVYGSDQTHSTYAKACNLAGILPCNIRSIRTEAVANFSLSPDSLHREIEADVAAGMVPLYLCATVGTTSTTAIDSLSPLADVANDYGLWFHVDAAYAGSACICPEFRHYLDGIERADSLSLSPHKWLLSYLDCCCLWVKRPSVLVKALSTDPEYLKNKPSESNSVVDFKDWQVGTGRRFKALRLWFVMRSYGVANLQSHIRSDIQMAKMFEEFVNSDPRFEIVVPRVFSLVCFRLNPFSKSDPCNTELLNRKLLEWVNSTGQVYITHTKVGGVYMLRFAVGATLTEEHHVSAAWKLIREGADALLCS

Gene
TDC2
Protein
Tryptophan decarboxylase 2
Organism
Oryza sativa subsp. japonica
Length
497 amino acids
Function
Involved in serotonin biosynthesis. Catalyzes the decarboxylation of L-tryptophan to tryptamine, which is converted to serotonin by tryptamine 5-hydroxylase (PubMed:17763868). May play a minor role in serotonin biosynthetis during senescence. Accumulation of serotonin attenuates leaf senescence (PubMed:19439571).
Similarity
Belongs to the group II decarboxylase family.
Mass
55.162 kDa
Sequence
MEGVGGGGGGEEWLRPMDAEQLRECGHRMVDFVADYYKSIEAFPVLSQVQPGYLKEVLPDSAPRQPDTLDSLFDDIQQKIIPGVTHWQSPNYFAYYPSNSSTAGFLGEMLSAAFNIVGFSWITSPAATELEVIVLDWFAKMLQLPSQFLSTALGGGVIQGTASEAVLVALLAARDRALKKHGKHSLEKLVVYASDQTHSALQKACQIAGIFSENVRVVIADCNKNYAVAPEAVSEALSIDLSSGLIPFFICATVGTTSSSAVDPLPELGQIAKSNDMWFHIDAAYAGSACICPEYRHHLNGVEEADSFNMNAHKWFLTNFDCSLLWVKDRSFLIQSLSTNPEFLKNKASQANSVVDFKDWQIPLGRRFRSLKLWMVLRLYGVDNLQSYIRKHIHLAEHFEQLLLSDSRFEVVTPRTFSLVCFRLVPPTSDHENGRKLNYDMMDGVNSSGKIFLSHTVLSGKFVLRFAVGAPLTEERHVDAAWKLLRDEATKVLGKMV