TBF1

Transcription factor TBF1

886 amino acids

Essential transcriptional activator that binds the telomeric double-stranded TTAGGG repeat and negatively regulates telomere length. Involved in the regulation of gene expression. Bind both the promoters of ribosomal protein genes and the rDNA locus and activates transcription at these loci. Recruits FHL1 and IFH1 to promoters.

100.905 kDa

MSDQLEKDIEESIANLDYQQNQEHHETEQDKDKEHQDVEKQSSEEETKGIEHVTDSNTDVIGVTKSQDTEEVIENSPVDPQLKEQQESTTKMSLSERDLVDEIDELFTNSTKTVTENNQPSETNKRAYESVETPQELTPNDKRQKLDANTETSVPTELESVNNHNEQSQPIEPTQERQPSTTETTYSISVPVSTANEVERASSSINEQEDLEMIAKQYQQATNLEIERAMEGHGDGGQHFSTQENGQPSGSSLISSIVPSDSELLNTNQAYAAYTSLSSQLEQHTSASAMLSSATLSALPLSIIAPVYLPPRIQLLINTLPTLDNLATQLLRTVATSPYQKIIDLASNPDTSAGATYRDLTSLFEFTKRLYSEDDPFLTVEHIAPGMWKEGEETPSIFKPKQQSIESTLRKVNLATFLAATLGTMEIGFFYLNESFLDVFCPSNNLDPSNALSNLGGYQNGLQSTDSPVGARVGKLLKPQATLYLDLKTQAYISAIEAGERSKEEILEDILPDDLHVYLMSRRNAKLLSPTETDFVWRCKQRKELLLNYTEETPLSEQYDWFTFLRDLFDYVSKNIAYLIWGKMGKTMKNRREDTPHTQELLDNTTGSTQMPNQLSSSSGQASSTPSVVDPNKMLVSEMREANIAVPKPSQRRAWSREEEKALRHALELKGPHWATILELFGQGGKISEALKNRTQVQLKDKARNWKKFFLRSGLEIPSYLRGVTGGVDDGKRKKDNVTKKTAAAPVPNMSEQLQQQQQRQQEKQEKQQQEEQQAQQSEQQQEPQQEQQQEQQQEQQQEQQQEQQQEQQQEQQQEQQQEQQQEQREETQQTEQEQPDQPQEEQQQEKEQPDQQQQEKEQPDQQQPDQQHPDRQQQEQIQQPESSDK

TBF1

Protein TBF1

562 amino acids

Binds the telomeric double-stranded TTAGGG repeat and negatively regulates telomere length. Involved in the regulation of gene expression. 52 binding sites have been identified, distributed over 15 chromosomes. A member of the general regulatory factors (GRFs) which act as genome partitioners. Acts as a chromatin insulator which are known as STARs (Subtelomeric anti-silencing region). STARs prevent negative or positive transcription influence by extending across chromotin to a promoter.

62.824 kDa

MDSQVPNNNESLNRFNDIIQSLPARTRLTICSLCLLDNISTQLLRFLILNANSPNIIAVLTDQTAFLSSGETEIFQTLVKLFKQIRMIYHTRSPLLSVHDVAPGLWFPNSPPPLILRGHEAFIITAIRKANLLTFLLTSLNCLNYGFELLQSIFLDIFCPNTNTVGNNSLEQSGKFLKSQAILYLDLKTQAYIAGLKEFQDETNEISLEKKQELLDLIFPSNLADILVQRRTGDSGDITLLTPSEKDFVERCDRRRENLKIVQDFNSLTQSYEWAQFIRELLDYCNKNMGLIIWGRKGRGKSPLYDFDVNEFDPQVLFSTGTRTVEFMDDQNQPSSASAFLSTARPNHYSTHTPTTDVSSKNPAITQSIVDAAVAASMSNSSSGPHSSHNNSSNSNNNGSIGLRKPKAKRTWSKEEEEALVEGLKEVGPSWSKILDLYGPGGKITENLKNRTQVQLKDKARNWKLQYLKSGKPLPDYLIKVTGNLEKIYKAKKKFSQSPNSSTIMEQNLSQHPSSAASATEDTQTHQEDSHGQNSDNMPSNGLFGNSTSDNTGFDPHLEDGM