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TBC1D7

Gene
tbc1d7
Protein
TBC1 domain family member 7
Organism
Danio rerio
Length
294 amino acids
Function
Component of the TSC-TBC complex, that contains tbc1d7 in addition to the TSC1-TSC2 complex and consists of the functional complex possessing GTPase-activating protein (GAP) activity toward rheb in response to alterations in specific cellular growth conditions. The small GTPase rheb is a direct activator of the protein kinase activity of mTORC1 and the TSC-TBC complex acts as a negative regulator of mTORC1 signaling cascade by acting as a GAP for RHEB (By similarity).
Mass
33.989 kDa
Sequence
MADDPQRNFRSAYYEKVGFRGVEEKKSLEILLKDNPLDVEKLSTFSQRFPLPSMYRIHVWKVLLGILPPHSDSHALVRQYRVDQFEDVSCALTVMRFIHASTPQTEIYLRMFQLENHTLPRRTELRPPDAEDENFLAIARAMEEIVDDPVDCFWLVRCFINQFKHKFGDSIPHLPKSLEHFLSQEDVCLLSHLKASGALALLPYSLWFRRCFAGCLPESSLQRVWDKVISGSCKILVFVAVEILLSHKIVIMGMNQPDAIYHFLSNMPQENTDAIVTKAIDLWHKYCGTPMHSV

Gene
TBC1D7
Protein
TBC1 domain family member 7
Organism
Bos taurus
Length
293 amino acids
Function
Component of the TSC-TBC complex, that contains TBC1D7 in addition to the TSC1-TSC2 complex and consists of the functional complex possessing GTPase-activating protein (GAP) activity toward RHEB in response to alterations in specific cellular growth conditions. The small GTPase RHEB is a direct activator of the protein kinase activity of mTORC1 and the TSC-TBC complex acts as a negative regulator of mTORC1 signaling cascade by acting as a GAP for RHEB. Participates in the proper sensing of growth factors and glucose, but not amino acids, by mTORC1. It is unclear whether TBC1D7 acts as a GTPase-activating protein and additional studies are required to answer this question (By similarity).
Mass
33.904 kDa
Sequence
MTEDSQRNFRSVYYEKVGFRGVEEKKSLEILLKDDRLDIEKLCTFSQRFPLPSMYRALVWKVLLGILPPHHESHVQVMTYRKEQYSDVLHALKVIRFVSDATPQSEVYLYMHRLESGKLPRSPSFPLEPEDEVFLAIAKAMEEMVEDSVDCYWIMRCFVNQLNSKYRDTLPQLPKAFEQYLNLEDSRLLSHLKACCAVSTLPYELWFKKCFAGCLPESSLQRIWDKVVSGSCKILVFVAVEILLTFKIKVMALNSAEKITKFLENIPQDSSDAIVSKAIDLWHKHCGTPVHSA

Gene
TBC1D7
Protein
TBC1 domain family member 7
Organism
Homo sapiens
Length
293 amino acids
Function
Component of the TSC-TBC complex, that contains TBC1D7 in addition to the TSC1-TSC2 complex and consists of the functional complex possessing GTPase-activating protein (GAP) activity toward RHEB in response to alterations in specific cellular growth conditions. The small GTPase RHEB is a direct activator of the protein kinase activity of mTORC1 and the TSC-TBC complex acts as a negative regulator of mTORC1 signaling cascade by acting as a GAP for RHEB. Participates in the proper sensing of growth factors and glucose, but not amino acids, by mTORC1. It is unclear whether TBC1D7 acts as a GTPase-activating protein and additional studies are required to answer this question.
Mass
33.972 kDa
Sequence
MTEDSQRNFRSVYYEKVGFRGVEEKKSLEILLKDDRLDTEKLCTFSQRFPLPSMYRALVWKVLLGILPPHHESHAKVMMYRKEQYLDVLHALKVVRFVSDATPQAEVYLRMYQLESGKLPRSPSFPLEPDDEVFLAIAKAMEEMVEDSVDCYWITRRFVNQLNTKYRDSLPQLPKAFEQYLNLEDGRLLTHLRMCSAAPKLPYDLWFKRCFAGCLPESSLQRVWDKVVSGSCKILVFVAVEILLTFKIKVMALNSAEKITKFLENIPQDSSDAIVSKAIDLWHKHCGTPVHSS

Gene
Tbc1d7
Protein
TBC1 domain family member 7
Organism
Mus musculus
Length
293 amino acids
Function
Component of the TSC-TBC complex, that contains TBC1D7 in addition to the TSC1-TSC2 complex and consists of the functional complex possessing GTPase-activating protein (GAP) activity toward RHEB in response to alterations in specific cellular growth conditions. The small GTPase RHEB is a direct activator of the protein kinase activity of mTORC1 and the TSC-TBC complex acts as a negative regulator of mTORC1 signaling cascade by acting as a GAP for RHEB. Participates in the proper sensing of growth factors and glucose, but not amino acids, by mTORC1. It is unclear whether TBC1D7 acts as a GTPase-activating protein and additional studies are required to answer this question.
Mass
33.826 kDa
Sequence
MTDDSQRNFRSVYYEKVGFRGVEEKKSLEILLKDDRLDIEKLCTFSQRFPLPSMYRALVWKALLGILPPHHDTHSQVMAYRKDQYHDILHALTVVRFISDATPQAEVYLRMYQLESGKLPRSPSFPLEPEDEVFLAIAKAMEEMVEDSVDCYWISRCFVKQLNNKYRDALPQLPKAFEQYLNLEDSRLLSHLKTCSAVSKLPYDLWFQRCFAGCLPESSLQRVWDKVVSGSCKILVFVAVEILLTFKIKVMALNSAEKITKFLENIPQDSSDAIVSKAIDLWHKHCGTPVHSA

Gene
tbc1d7
Protein
TBC1 domain family member 7
Organism
Xenopus tropicalis
Length
293 amino acids
Function
Component of the TSC-TBC complex, that contains tbc1d7 in addition to the TSC1-TSC2 complex and consists of the functional complex possessing GTPase-activating protein (GAP) activity toward rheb in response to alterations in specific cellular growth conditions. The small GTPase rheb is a direct activator of the protein kinase activity of mTORC1 and the TSC-TBC complex acts as a negative regulator of mTORC1 signaling cascade by acting as a GAP for RHEB (By similarity).
Mass
34.283 kDa
Sequence
MSEDSQRNFRSVYYEKVGFRGVEEKKSLEILLKDDRLDIEKLCTFSQRFPLPSMYRILVWKVLLGILPHHQESHPMVMEYRREQYQDVYHALQVIHFISEATPKIEVFLYMYHLETGKLSQSQPYPMEPEDDIFLAIASTMEEMVDDDVDCYWLIRNFVNHFDSKFKDSKLQLHKAFEHYLNLEDSRLVAHLKASSALEKLPYDLWFKKCFAGCLSASSLQRVWDKLVSGSCKILVFVAVEILLTYKLKVTALNNAESINKFLEKIPEDNTDPIVSKAIDLWHKHCGIPAHSI