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TAS2R46

Gene
TAS2R46
Protein
Taste receptor type 2 member 46
Organism
Gorilla gorilla gorilla
Length
309 amino acids
Function
Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity). In airway epithelial cells, binding of bitter compounds increases the intracellular calcium ion concentration and stimulates ciliary beat frequency (By similarity).
Similarity
Belongs to the G-protein coupled receptor T2R family.
Mass
35.567 kDa
Sequence
MITFLPIIFSILIVVTFVIGNFANGFIALANSIEWFKRQKISFADQILTALAVSRVGLLWVLLLNWYATELNPAFYSIEVRITAYNVWAVISHFSNWLATSLSIFYLLKIANFSNLIFLRLKRRVKSVVLVILLGPLLFLVCHLFVINMNQIIWTKEYEGNMTWKIKLRSAMYLSDTTVTILANLVPFTLTLISFLLLICSLCKHLKKMQLHGKGSQDPSMKVHIKALQTVTSFLLLCAIYFLSVIMSVWSFESLENKPVFMFCEAITFSYPSTHPFILIWGNKKLKQTFLSVLWHVRYWVKGEKPSSS

Gene
TAS2R46
Protein
Taste receptor type 2 member 46
Organism
Homo sapiens
Length
309 amino acids
Function
Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity). In airway epithelial cells, binding of bitter compounds increases the intracellular calcium ion concentration and stimulates ciliary beat frequency (By similarity).
Similarity
Belongs to the G-protein coupled receptor T2R family.
Mass
35.523 kDa
Sequence
MITFLPIIFSILIVVTFVIGNFANGFIALVNSIEWFKRQKISFADQILTALAVSRVGLLWVLVLNWYATELNPAFNSIEVRITAYNVWAVINHFSNWLATSLSIFYLLKIANFSNLIFLHLKRRVKSVVLVILLGPLLFLVCHLFVINMNQIIWTKEYEGNMTWKIKLRSAMYLSNTTVTILANLVPFTLTLISFLLLICSLCKHLKKMQLHGKGSQDPSMKVHIKALQTVTSFLLLCAIYFLSIIMSVWSFESLENKPVFMFCEAIAFSYPSTHPFILIWGNKKLKQTFLSVLWHVRYWVKGEKPSSS

Gene
TAS2R46
Protein
Taste receptor type 2 member 46
Organism
Pan paniscus
Length
309 amino acids
Function
Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity). In airway epithelial cells, binding of bitter compounds increases the intracellular calcium ion concentration and stimulates ciliary beat frequency (By similarity).
Similarity
Belongs to the G-protein coupled receptor T2R family.
Mass
35.644 kDa
Sequence
MITFLPIIFSILIVVTFVIGNFANGFIALANSIEWFKRQKISFADQILTALAVSRVGLLWVLLLNWYATELNPAFYSIEVRITAYNLWAVINHFSNWLATSLSIFYLLKIANFSNLIFLRLKRRVKSVVLVILLGPLLFLVCHLFVINMNQIIWTKEYEGNMTWKIKLRSAMYLSNITVTILANLVPFTLTLISFLLLICSLCKHLKKMQLHGKGSQDPSMKVHIKALQTVTSFLLLCAIYFLSIIMSVWSFESLENKPVFMFCEAITFSYPSTHPFILIWGNKKLKQTFLSVLWHVRYWVKGEEPSSP

Gene
TAS2R46
Protein
Taste receptor type 2 member 46
Organism
Pan troglodytes
Length
309 amino acids
Function
Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity). In airway epithelial cells, binding of bitter compounds increases the intracellular calcium ion concentration and stimulates ciliary beat frequency (By similarity).
Similarity
Belongs to the G-protein coupled receptor T2R family.
Mass
35.603 kDa
Sequence
MITFLPIIFSILIVVTFVIGNFANGFIALANSIEWFKRQKISFADQILTALAVSRVGLLWVLLLNWYATELNPAFYSIEVRITAYNLWAVINHFSNWLATSLSIFYLLKIANFSNLIFLCLKRRVKSVVLVILLGPLLFLVCHLFVINMNQIIWTKEYEGNMTWKIKLRSAMYLSNTTVTILANLVPFTLTLISFLLLICSLCKHLEKMQLHGKGSQDPSMKVHIKALQTVTSFLLLCAIYFLSIIMSVWSFESLENKPVFMFCEAITFSYPSTHPFILIWGNKKLKQTFLSVLWHVRYWVKGEKPSXP

Gene
TAS2R46
Protein
Taste receptor type 2 member 46
Organism
Papio hamadryas
Length
309 amino acids
Function
Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity). In airway epithelial cells, binding of bitter compounds increases the intracellular calcium ion concentration and stimulates ciliary beat frequency (By similarity).
Similarity
Belongs to the G-protein coupled receptor T2R family.
Mass
35.35 kDa
Sequence
MITFLPITFSILIVVIFFIGNFANGFIALINSIEWVKRQKISFAGQILTALAVSRVGLLWVLSLHWYATEFNLAFHSVEVRSTAYNVWVVTNHFSNWLSTSLSMFYLLRIATFSNLIFLHLNRRVKSVILVTLLGPLLFLVCQLFVMNMNQIVRTKEYEGNMTWKIKLKSAMYLSNTTVAMLANFVPLTLTLISFLLLICSLCKHLKKMRVHGKGSQDPSTKVHTKALQIVTSFLLVCAIYFLSIILSVWNSGGLENKPFFMFCQAIKFSYPSTHPFILIWGNKTLKQTFLSVLRNVRYWVKGQKPSSP

Gene
TAS2R46
Protein
Taste receptor type 2 member 46
Organism
Macaca mulatta
Length
308 amino acids
Function
Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity). In airway epithelial cells, binding of bitter compounds increases the intracellular calcium ion concentration and stimulates ciliary beat frequency (By similarity).
Similarity
Belongs to the G-protein coupled receptor T2R family.
Mass
35.462 kDa
Sequence
MITFLSITFSILVGVIFVIGNFANGFIALVNSIEWVKRQKISFADQILTGLAVSRVGLLWVLLLHLYATEFNLAFYSVEVRITAYNVWIVTNHFSNWLSTSLSMFYLLKIATFSNLIFLHLKRKVKSVILVTLLGPLLFLVCHLFVMNMNHIVWRKEYEGNITWRIKLRSAMYLSNVTVTMLANLIPLTLTLMSFLLLICSLCKHLKKMQVHGKGSQDPSTKVHIKALQTVTSFLLLCAIYFLSMILSVWNFELEKKPVFMFCQAVIFSYPSTHPLILIWGNKKLKQIFLSVLWNVRYWVKGQKPSSP