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TAP2

Gene
Tap2
Protein
Antigen peptide transporter 2
Organism
Rattus norvegicus
Length
703 amino acids
Function
Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin (By similarity).
Similarity
Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3.A.1.209) subfamily.
Mass
77.713 kDa
Sequence
MALSHPRPWASLLLVDLALLGLLQSSLGTLLPPGLPGLWLEGTLRLGVLWGLLKVGGLLRLVGTFLPLLCLTNPLFFSLRALVGSTMSTSVVRVASASWGWLLADYGAVALSLAVWAVLSPAGAQEKEPGQENNRALMIRLLRLSKPDLPFLIVAFIFLAMAVWWEMFIPHYSGRVIDILGGDFDPDAFASAIFFMCLFSVGSSLSAGCRGGSFLFAESRINLRIREQLFSSLLRQDLAFFQETKTGELNSRLSSDTSLMSQWLSLNANILLRSLVKVVGLYYFMLQVSPRLTFLSLLDLPLTIAAEKVYNPRHQAVLKEIQDAVAKAGQVVREAVGGLQTVRSFGAEEQEVRRYKEALERCRQLWWRRDLEKSLYLVIQRVMALGMQVLILNVGVQQILAGEVTRGGLLSFLLYQEEVGHHVQNLVYMYGDMLSNVGAAEKVFSYLDRRPNLPNPGTLAPPRLEGRVEFQDVSFSYPSRPEKPVLQGLTFTLHPGKVTALVGPNGSGKSTVAALLQNLYQPTGGQLLLDGEPLVQYDHHYLHRQVVLVGQEPVLFSGSVKDNIAYGLRDCEDAQVMAAAQAACADDFIGEMTNGINTEIGEKGSQLAVGQKQRLAIARALVRNPRVLILDEATSALDAECEQALQTWRSQEDRTMLVIAHRLHTVQNADQVLVLKQGQLVEHDQLRDEQDVYAHLVQQRLEA

Gene
Tap2
Protein
Antigen peptide transporter 2
Organism
Mus musculus
Length
702 amino acids
Function
Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin (By similarity).
Similarity
Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3.A.1.209) subfamily.
Mass
77.445 kDa
Sequence
MALSYLRPWVSLLLADMALLGLLQGSLGNLLPQGLPGLWIEGTLRLGVLWGLLKVGELLGLVGTLLPLLCLATPLFFSLRALVGGTASTSVVRVASASWGWLLAGYGAVALSWAVWAVLSPAGVQEKEPGQENRTLMKRLLKLSRPDLPFLIAAFFFLVVAVWGETLIPRYSGRVIDILGGDFDPDAFASAIFFMCLFSVGSSFSAGCRGGSFLFTMSRINLRIREQLFSSLLRQDLGFFQETKTGELNSRLSSDTSLMSRWLPFNANILLRSLVKVVGLYFFMLQVSPRLTFLSLLDLPLTIAAEKVYNPRHQAVLKEIQDAVAKAGQVVREAVGGLQTVRSFGAEEQEVSHYKEALERCRQLWWRRDLEKDVYLVIRRVMALGMQVLILNCGVQQILAGEVTRGGLLSFLLYQEEVGQYVRNLVYMYGDMLSNVGAAEKVFSYLDRKPNLPQPGILAPPWLEGRVEFQDVSFSYPRRPEKPVLQGLTFTLHPGTVTALVGPNGSGKSTVAALLQNLYQPTGGQLLLDGEPLTEYDHHYLHRQVVLVGQEPVLFSGSVKDNIAYGLRDCEDAQVMAAAQAACADDFIGEMTNGINTEIGEKGGQLAVGQKQRLAIARALVRNPRVLILDEATSALDAQCEQALQNWRSQGDRTMLVIAHRLHTVQNADQVLVLKQGRLVEHDQLRDGQDVYAHLVQQRLEA

Gene
TAP2
Protein
Antigen peptide transporter 2
Organism
Homo sapiens
Length
686 amino acids
Function
Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. Inhibited by the covalent attachment of herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP. Inhibited by human cytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP1 and prevents the conformational rearrangement of TAP induced by peptide binding. Inhibited by human adenovirus E3-19K glycoprotein, which binds the TAP complex and acts as a tapasin inhibitor, preventing MHC class I/TAP association.
Similarity
Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3.A.1.209) subfamily.
Mass
75.664 kDa
Sequence
MRLPDLRPWTSLLLVDAALLWLLQGPLGTLLPQGLPGLWLEGTLRLGGLWGLLKLRGLLGFVGTLLLPLCLATPLTVSLRALVAGASRAPPARVASAPWSWLLVGYGAAGLSWSLWAVLSPPGAQEKEQDQVNNKVLMWRLLKLSRPDLPLLVAAFFFLVLAVLGETLIPHYSGRVIDILGGDFDPHAFASAIFFMCLFSFGSSLSAGCRGGCFTYTMSRINLRIREQLFSSLLRQDLGFFQETKTGELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYGFMLSISPRLTLLSLLHMPFTIAAEKVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTVRSFGAEEHEVCRYKEALEQCRQLYWRRDLERALYLLVRRVLHLGVQMLMLSCGLQQMQDGELTQGSLLSFMIYQESVGSYVQTLVYIYGDMLSNVGAAEKVFSYMDRQPNLPSPGTLAPTTLQGVVKFQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQVLLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCEDDKVMAAAQAAHADDFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDEATSALDVQCEQALQDWNSRGDRTVLVIAHRLQTVQRAHQILVLQEGKLQKLAQL

Gene
TAP2
Protein
Suberization-associated anionic peroxidase 2
Organism
Solanum lycopersicum
Length
363 amino acids
Function
Suggested to catalyze the deposition of the aromatic residues of suberin on the cell wall and thus play a role in cell-suberization.
Similarity
Belongs to the peroxidase family. Classical plant (class III) peroxidase subfamily.
Mass
38.547 kDa
Sequence
MGFRLSLLSLAVSLVALALAGVAIYRNTYEAMIMNNGSLLQNISPDIDSLESGEVSILILNDKKKNSDKYLSQQLTQESCVFSAVKGVVDSAIDNETRMGASLIRLHFHDCFVDGCDGGILLDDINGTFTGEQNSPPNNNSVRGFEVIAQAKQSVVDSCPNISVSCADILAIAARDSLAKLGGQTYTVALGRSDATTANFSGAINQLPAPSDNLTVQIQKFSDKNFTVREMVALAGAHTVGFARCSTVCTSGNVNPAAQLQCNCSATLTDSDLQQLDTTPAVFDKVYYDNLNNNQGIMFSDQVLTGNTTTAGFVTTYSNNVTVFLEDFAAAMIKMGNLPPSAGAQLEIRDVCSRVNPTSVASM

Gene
TAP2
Protein
Probable acetyltransferase TAP2
Organism
Glycine max
Length
248 amino acids
Function
May acetylate histones H2A and H3.
Similarity
Belongs to the acetyltransferase family.
Mass
27.554 kDa
Sequence
MLTFNLNAISSSFSVVPFHANYPLSTQTQLLVPSNLSYSFATTGTRKFKSFQLKAGFWESIKSGLMKNNSMQVIDPPSADEEDEEPLPQEFVLVEKTEPDGTIEQIIFSSGGDVDVYDLQALCDKGWPRRPLSKLAAALKNSYIVASLHSIRKSPGSEGNEQKRLIGMARATSDHAFNATIWDVLVDPGYQGQGLGKALIEKLIRTLLQRDIGNITLFADSQVVEFYRNLGFEADPEGIKGMFWYPNH

Gene
TAP2
Protein
Protein TAP2
Organism
Antirrhinum majus
Length
131 amino acids
Mass
14.402 kDa
Sequence
MAKSSPTYTVLFLLGLLALSTATTTFQNEGQRSLIGQFNSRGTFKKIKNHPSESVQRSNEDFAMHKTKLKHKFVARSGGETDVKKMEGSMPDQGKTAGRDQQVTVQNIKEASKENVGGNTNDIYKSGGMHH