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TAF8

Gene
TAF8
Protein
Transcription initiation factor TFIID subunit 8
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Length
510 amino acids
Function
Functions as a component of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription.
Similarity
Belongs to the TAF8 family.
Mass
57.986 kDa
Sequence
MTSKTSESGTGTQSTIVQLRNLPDLTEISHLEIDAPVVEILKKTVLFQLNSLNICISNFALDELVNLVTVQMDGMFRNLHNLTLLQRRSQASQADLKLLLREFNLDAPSLYQQFQASEFIKSKHSTEYEKLMSWSSLAALPHNEEDEEDELNNIEEQQNEINVLLPPSNPLEKQIPSWLPNFPPDHTYKFTPEFNHPITDLKTIKKEIVKESQESEKALLNLNKSLSHISSASNTPQPPGLDDEDAIEQQLEIWGNALEERKPTITEKSFNENNIEQYAKYRVELARERVTKFEVNQLKRTKNPFLKISETLYLPESPHQSHKTIQKTIELQFRKSMTLFMHNLPKVQKLKKEKIRMAKEERAKSLKRRQEELISQRTKREQDEGHDLELLLNNEHARDAADDTTTPNALNNSTIVINTNAEDEDDDINLFGILGSSEDENEMSSMPAENLVAESEPPTMTAQDTTNTTPVAHNTTNIDATTSHSPHSTPNENAPTSPPADIATDHDITM

Gene
TAF8
Protein
Transcription initiation factor TFIID subunit 8
Organism
Arabidopsis thaliana
Length
353 amino acids
Function
TAFs are components of the transcription factor IID (TFIID) complex that is essential for mediating regulation of RNA polymerase transcription.
Similarity
Belongs to the TAF8 family.
Mass
39.546 kDa
Sequence
MNTERAQEGDRNDAASSSGCSESYEFSHAAAKAAVAQVCESVGYENFKDPALESLSGFALQYILQLGKTATSFANLTGRSQCNVFDIILALDDLTDNNGEQGISSESCSLGRSIKLREIIDFVNSSEEVPFSQPLPSFPVAISDRSRKMIPSFVEIGETPPGKHIPLWLPAFPDPHTYKETPMWIERVSDPRGDKIEQARQRRKAERALLSLQRKLVCKISSRNPVWGDMDGVKEEMRDDESELRSVSSGEKVESLNRDGLSVIEAFAPAMEAARDGFSSEAHTEWKKNKPVALSKLRTEKKFLGQPLDLSLQMKGEDRPISFVREEDRDDKRRRAEFILRQCMENPVDLNQL

Gene
Taf8
Protein
Transcription initiation factor TFIID subunit 8
Organism
Drosophila melanogaster
Length
328 amino acids
Function
TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors.
Similarity
Belongs to the TAF8 family.
Mass
36.649 kDa
Sequence
MEKVEAVTVSNVDPYRRILNKVVSQLLLDKGAGQASNHSLETLTQMLQALIWEIGNSAHNYCELSGRTMPTVGDVSLALINMGISISNLDPYMRKETHVPIPLPPQQTQQRPLSLLQAGIKAPHPHYVPSYFPPMPDPHAYIRTPTHKQPVTEYEAIREKAACQKRDIEKALTKFLCKTTETNNLFPTEDNMFPLIACKPAFPPYAAALNPTDQVFDFEELEYHYLVANRTEDEPSKDDGEEGDSENEEMDGDKSKEEKPELDIKPNSNTNKAILENPNIDNPYLRAATLPKRSKNCPTPGTMPSRSLATTAPTIRTPSTLEITKTNL

Gene
TAF8
Protein
Transcription initiation factor TFIID subunit 8
Organism
Homo sapiens
Length
310 amino acids
Function
Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by RNA polymerase II. Mediates both basal and activator-dependent transcription. Plays a role in the differentiation of preadipocyte fibroblasts to adipocytes, however, does not seem to play a role in differentiation of myoblasts. Required for the integration of TAF10 in the TAF complex. May be important for survival of cells of the inner cell mass which constitute the pluripotent cell population of the early embryo (By similarity).
Similarity
Belongs to the TAF8 family.
Mass
34.262 kDa
Sequence
MADAAATAGAGGSGTRSGSKQSTNPADNYHLARRRTLQVVVSSLLTEAGFESAEKASVETLTEMLQSYISEIGRSAKSYCEHTARTQPTLSDIVVTLVEMGFNVDTLPAYAKRSQRMVITAPPVTNQPVTPKALTAGQNRPHPPHIPSHFPEFPDPHTYIKTPTYREPVSDYQVLREKAASQRRDVERALTRFMAKTGETQSLFKDDVSTFPLIAARPFTIPYLTALLPSELEMQQMEETDSSEQDEQTDTENLALHISMEDSGAEKENTSVLQQNPSLSGSRNGEENIIDNPYLRPVKKPKIRRKKSLS

Gene
TAF8
Protein
Transcription initiation factor TFIID subunit 8
Organism
Bos taurus
Length
310 amino acids
Function
Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by RNA polymerase II. Mediates both basal and activator-dependent transcription. Plays a role in the differentiation of preadipocyte fibroblasts to adipocytes, however, does not seem to play a role in differentiation of myoblasts. Required for the integration of TAF10 in the TAF complex. May be important for survival of cells of the inner cell mass which constitute the pluripotent cell population of the early embryo (By similarity).
Similarity
Belongs to the TAF8 family.
Mass
34.227 kDa
Sequence
MADAAATAGAAGSGTRSGSKQSTNPADNYHLARRRTLQVVVSSLLTEAGFESAEKASVETLTEMLQSYISEIGRSAKSYCEHTARTQPTLSDIVVTLVEMGFNVDTLPAYAKRSQRMVITAPPVTNQPVTPKALTAGQNRPHPPHIPSHFPEFPDPHTYIKTPTYREPVSDYQVLREKAASQRRDVERALTRFMAKTGETQSLFKDDVSTFPLIAARPFTIPYLTALLPSELEMQQMEETDSSEQDEQTDTENLPLHISPDDSGAEKENTSVLQQNPSLSGSRNGEESIIDNPYLRPVKKPKIRRKKSLS

Gene
Taf8
Protein
Transcription initiation factor TFIID subunit 8
Organism
Mus musculus
Length
308 amino acids
Function
Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by RNA polymerase II. Mediates both basal and activator-dependent transcription. Plays a role in the differentiation of preadipocyte fibroblasts to adipocytes, however does not seem to play a role in differentiation of myoblasts. Required for the integration of TAF10 in the TAF complex (By similarity). May be important for survival of cells of the inner cell mass which constitute the pluripotent cell population of the early embryo.
Similarity
Belongs to the TAF8 family.
Mass
33.988 kDa
Sequence
MADTAAGPGGSGTRPGSKQSTNPADNYHLARRRTLQVVVSSLLTEAGFESAEKASVETLTEMLQSYISEIGRSAKSYCEHTARTQPTLSDIVVTLVEMGFNVDTLPAYAKRSQRMVITAPPVTNQPVTPKALTAGQNRPHPPHIPSHFPEFPDPHTYIKTPTYREPVSDYQILREKAASQRRDVERALTRFMAKTGETQSLFKDDVSTFPLIAARPFTIPYLTALLPSELEIQQMEETDSSEQEEQTDTENNALHISTDDSGAEKESASVLQQSSSLSGSRNGEESVIDNPYLRPVKKPKIRRKKSLS

Gene
taf8
Protein
Transcription initiation factor TFIID subunit 8
Organism
Danio rerio
Length
308 amino acids
Function
Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by RNA polymerase II. Mediates both basal and activator-dependent transcription (By similarity).
Similarity
Belongs to the TAF8 family.
Mass
33.912 kDa
Sequence
MADSVMMGSGSLNSGSRSGSSKTCTSPTENYQLARRRTLQVVVSALLTECGFDSAEKAVVETLTEMMQSYITEVGRCAKANCEHTARSTPTLSDVVITLVEMGFNVDTLPVYAKRSQRMVITAPPITNAPVVPKSLTAGQKRTHPAHIPSHFPDFPDPHTYIRTPTFREPVSDYQVVREKAASQRRDVERALTRFMAKTGETQSLFKDDISAFPLIAAKPSPIPYLSALLPSELELQSLEETDSSEQDDQMDNDNNTSHIMQDDSGADKENEVLPPGGVVPSGKANEENMIDNPYLRPVKKPKVRRKK

Gene
taf8
Protein
Transcription initiation factor TFIID subunit 8
Organism
Xenopus laevis
Length
293 amino acids
Function
Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by RNA polymerase II. Mediates both basal and activator-dependent transcription (By similarity).
Similarity
Belongs to the TAF8 family.
Mass
32.733 kDa
Sequence
MFPTIRSCARGTSTPADNYMLARRRTLQVVVSSLLTEAGFDSAEKAAVESLTEMLQSYLSEIGRSAKSYCEHTARTQPTLPDIVVTLIEMGFNVDSLPAYAKRSQRMVITAPPVTNNPVVPKALSAGDNKPHPAHIPSHFPEFPDPHTYIKTPTYREPVCDYQVLREKAASQRRDVERALTRFMAKTGETQSLFKDDTSTFPLIAARPLSIPYLNALLPSELELQQVDETDSSEQDDQTDTENLSLHLQGDEVGMEKENASVLQQNSMKGGEETLIDNPYLRPVKKPKLRRKK

Gene
taf8
Protein
Transcription initiation factor TFIID subunit 8
Organism
Xenopus tropicalis
Length
293 amino acids
Function
Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by RNA polymerase II. Mediates both basal and activator-dependent transcription (By similarity).
Similarity
Belongs to the TAF8 family.
Mass
32.823 kDa
Sequence
MFPTIRSCARGTSTPADNYMLARRRTLQVVVSSLLTEAGFESAEKAAVESLTEMLQSYLSEIGRSAKSYCEHTARTQPTLPDIVVTLIEMGFNVESLPAYAKRSQRMVITAPPVTNNPVVPKALSAGQNKQHPAHIPSHFPEFPDPHTYIKTPTYREPVCDYQVLREKAASQRRDVERALTRFMAKTGETQSLFKDDTSTFPLIAARPLSIPYLNALLPSELELQQVEETDSSEQDDQTDAENLSMHLQGDEVGMEKENSSVLQQNSMKGGEETLIDNPYLRPVKKPKLRRKK

Gene
TAF8
Protein
Transcription initiation factor TFIID subunit 8
Organism
Gallus gallus
Length
244 amino acids
Function
Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by RNA polymerase II. Mediates both basal and activator-dependent transcription (By similarity).
Similarity
Belongs to the TAF8 family.
Mass
27.511 kDa
Sequence
MLQSYISEIGRSAKSYCEHTARTQPTLSDIVVTLVEMGFNVETLPAYAKRSQRMVITAPPVTNQPVTPKALTAGQNKPHPSHIPGYFPEFPDPHTYIKTPTYREPVSDYQVLREKAASQRRDVERALTRFMAKTGETQSLFKDDVSTFPLIAARPFTVPYLTALLPSELEMQQMEETDSSEQDDQTDTENLPLHISTDDSGPEKENASVLQQNTSLSGSRNGEENMIDNPYLRPVKKPKIRRKK

Gene
taf8
Protein
Transcription initiation factor TFIID subunit 8
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Length
222 amino acids
Function
Functions as a component of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification, facilitation of DNA opening and initiation of transcription (By similarity).
Similarity
Belongs to the TAF8 family.
Mass
25.004 kDa
Sequence
MEAVIANILQQLGFDSMTKAAEASFVEAVDKYLRNSFRELALHTQLSKHTIPTTKDVALWLNLLNIPMSSLQTELEKYLKPLPPAINDELDRLANESQDIPSKFKSSLDSKMVSQLLGSLAVSQNRPAYVVNHLPPFPASHTYMATPVYPVRPTSPKQIRELATQESRLAEHALRKILNVNQPRSADSPRHASFEKACSELNLDVSSFHLVNWESQKWSSQR