Taf6

Transcription initiation factor TFIID subunit 6

678 amino acids

TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TIIFD is multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors (By similarity).

Belongs to the TAF6 family.

72.673 kDa

MAEEKKLKLSNTVLPSESMKVVAESMGIAQIQEETCQLLTDEVSYRIKEIAQDALKFMHMGKRQKLTTSDIDYALKLKNVEPLYGFHAQEFIPFRFASGGGRELYFYEEKEVDLSDIINTPLPRVPLDVCLKAHWLSIEGCQPAIPENPPPAPKEQQKAEATEPLKSAKPGQEEDGPLKGKGQGAAAADGKGKEKKAPPLLEGAPFRLKPRSIHELSVEQQLYYKEITEACVGSCEAKRAEALQSIATDPGLYQMLPRFSTFISEGVRVNVVQNNLALLIYLMRMVKALMDNPTLYLEKYVHELIPAVMTCIVSRQLCLRPDVDNHWALRDFAARLVAQICKHFSTTTNNIQSRITKTFTKSWVDEKTPWTTRYGSIAGLAELGHDVIKTLILPRLQQEGERIRSVLDGPVLSNIDRIGADHVQSLLLKHCAPVLAKLRPPPDNQDAYRGEFGSLGPLLCSHVVKARAQAALQAQQVNRTTLTITQPRPTLTLSQAPQPGPRTPGLLKVPGSIALPVQTLVSARAAAPPQPSPPPTKFIVMSSSSSASSTQQVLSLSTSAPGSGSTTTSPVTTTVPSVQPIVKLVSTATTAPPSTAPAGSGSVQKYIVVSLPPTGEGKGGPPSHPSPVPPSSSSPSPLGGSTLCGGKQEAGDSPPPAPGTPKANGSQPTGPGSPQPAL

Taf6

Transcription initiation factor TFIID subunit 6

678 amino acids

TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TIIFD is multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors (By similarity).

Belongs to the TAF6 family.

72.713 kDa

MAEEKKLKLSNTVLPSESMKVVAESMGIAQIQEETCQLLTDEVSYRIKEIAQDALKFMHMGKRQKLTTSDIDYALKLKNVEPLYGFHAQEFIPFRFASGGGRELYFYEEKEVDLSDIINTPLPRVPLDVCLKAHWLSIEGCQPAIPENPPPAPKEQQKAEATEPLKSAKPGQEEDGPLKGKGQGAAAADGKGKEKKAPPLLEGAPFRLKPRSIHELSVEQQLYYKEITEACVGSCEAKRAEALQSIATDPGLYQMLPRFSTFISEGVRVNVVQNNLALLIYLMRMVKALMDNPTLYLEKYVHELIPAVMTCIVSRQLCLRPDVDNHWALRDFAARLVAQICKHFSTTTNNIQSRITKTFTKSWVDEKTPWTTRYGSIAGLAELGHDVIKTLILPRLQQEGERIRSVLDGPVLSNIDRIGADHVQSLLLKHCAPVLAKLRPPPDNQDAYRGEFGSLGPLLCSHVVKARAQAALQAQQVNRTTLTITQPRPTLTLSQAPQPGPRTPGLLKVPGSIALPVQTLVSARAAAPPQPSPPPTKFIVMSSSSSASSTQQVLSLSTSAPGSGSTTTSPVTTTVPSVQPIVKLVSTATTAPPSTAPAGPGSVQKYIVVSLPPTGEGKGGPPSHPSPVPPSSSSPSPLGGSALCGGKQETGDSPPPAPGTPKANGSQPTGPSSPQPAL

TAF6

Transcription initiation factor TFIID subunit 6

677 amino acids

Isoform 4: Transcriptional regulator which acts primarily as a positive regulator of transcription (PubMed:20096117, PubMed:29358700). Recruited to the promoters of a number of genes including GADD45A and CDKN1A/p21, leading to transcriptional up-regulation and subsequent induction of apoptosis (PubMed:11583621). Also up-regulates expression of other genes including GCNA/ACRC, HES1 and IFFO1 (PubMed:18628956). In contrast, down-regulates transcription of MDM2 (PubMed:11583621). Acts as a transcriptional coactivator to enhance transcription of TP53/p53-responsive genes such as DUSP1 (PubMed:20096117). Can also activate transcription and apoptosis independently of TP53 (PubMed:18628956). Drives apoptosis via the intrinsic apoptotic pathway by up-regulating apoptosis effectors such as BCL2L11/BIM and PMAIP1/NOXA (PubMed:29358700).

Belongs to the TAF6 family.

72.668 kDa

MAEEKKLKLSNTVLPSESMKVVAESMGIAQIQEETCQLLTDEVSYRIKEIAQDALKFMHMGKRQKLTTSDIDYALKLKNVEPLYGFHAQEFIPFRFASGGGRELYFYEEKEVDLSDIINTPLPRVPLDVCLKAHWLSIEGCQPAIPENPPPAPKEQQKAEATEPLKSAKPGQEEDGPLKGKGQGATTADGKGKEKKAPPLLEGAPLRLKPRSIHELSVEQQLYYKEITEACVGSCEAKRAEALQSIATDPGLYQMLPRFSTFISEGVRVNVVQNNLALLIYLMRMVKALMDNPTLYLEKYVHELIPAVMTCIVSRQLCLRPDVDNHWALRDFAARLVAQICKHFSTTTNNIQSRITKTFTKSWVDEKTPWTTRYGSIAGLAELGHDVIKTLILPRLQQEGERIRSVLDGPVLSNIDRIGADHVQSLLLKHCAPVLAKLRPPPDNQDAYRAEFGSLGPLLCSQVVKARAQAALQAQQVNRTTLTITQPRPTLTLSQAPQPGPRTPGLLKVPGSIALPVQTLVSARAAAPPQPSPPPTKFIVMSSSSSAPSTQQVLSLSTSAPGSGSTTTSPVTTTVPSVQPIVKLVSTATTAPPSTAPSGPGSVQKYIVVSLPPTGEGKGGPTSHPSPVPPPASSPSPLSGSALCGGKQEAGDSPPPAPGTPKANGSQPNSGSPQPAP

taf6

Transcription initiation factor TFIID subunit 6

618 amino acids

TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Binds tightly to TAFII-250 and also directly interacts with TAFII-40 (By similarity).

Belongs to the TAF6 family.

66.858 kDa

MAEGKKIGNTLLPSESMKVISESVGISQMSEETCQLLAQEVSFRIKEVTQDALKFMHVGKRQKLTPSDIDAALKLKNVEPIYGFHPKEFLPFRYASGGGRELHFYEEKETDLSDIISTPLPRVPLDVSLKAHWLSIEGVQPAIPENPPPVPKEQQKTEATEPLKVAKPGQEEGLPGKGQGSGEGKGKEKKTAILEGAPLKLKPRSIHELSVEQQLYYKEITEACVGSCEAKRAEALQSIATDPGLYQMLPRFSTFISEGVRVNVVQNNLALLIYLMRMVKALMDNPTLYLEKYLHELIPAVMTCIVSRQLCLRPDVDNHWALRDFAARLIAQICKNFSTTTNNIQSRITKTFTKTWVDDRTPWTTRYGSIAGLAELGPDVVKTLIVPRLTVEGERLRSVLDGPVISNIDKIGADHVQSLLLKHSAPVLVKLRSPPDSPDAYRADYGYLGPTLCTHVLKARAQSALQGPQVNRTTLTVTQPRPTLTLSQPSGSLTPSPRTPSIIKVPSSLTLPVQTLMSARPATPTQPSPPPTKYIVVSSAGSSGTQVLTTSSGPSPSTPGVQPIVKLVSGGQSSGVGGSMTGTGGGMQKYIVVSLPPAGESKTPQPSPPPPTTETSTL

Taf6

Transcription initiation factor TFIID subunit 6

606 amino acids

TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors.

Belongs to the TAF6 family.

65.654 kDa

MSGKPSKPSSPSSSMLYGSSISAESMKVIAESIGVGSLSDDAAKELAEDVSIKLKRIVQDAAKFMNHAKRQKLSVRDIDMSLKVRNVEPQYGFVAKDFIPFRFASGGGRELHFTEDKEIDLGEITSTNSVKIPLDLTLRSHWFVVEGVQPTVPENPPPLSKDSQLLDSVNPVIKMDQGLNKDAAGKPTTGKIHKLKNVETIHVKQLATHELSVEQQLYYKEITEACVGSDEPRRGEALQSLGSDPGLHEMLPRMCTFIAEGVKVNVVQNNLALLIYLMRMVRALLDNPSLFLEKYLHELIPSVMTCIVSKQLCMRPELDNHWALRDFASRLMAQICKNFNTLTNNLQTRVTRIFSKALQNDKTHLSSLYGSIAGLSELGGEVIKVFIIPRLKFISERIEPHLLGTSISNTDKTAAGHIRAMLQKCCPPILRQMRSAPDTAEDYKNDFGFLGPSLCQAVVKVRNAPASSIVTLSSNTINTAPITSAAQTATTIGRVSMPTTQRQGSPGVSSLPQIRAIQANQPAQKFVIVTQNSPQQGQAKVVRRGSSPHSVVLSAASNAASASNSNSSSSGSLLAAAQRSSDNVCVIAGSEAPAVDGITVQSFRAS

TAF6

Transcription initiation factor TFIID subunit 6

549 amino acids

TAFs are components of the transcription factor IID (TFIID) complex that is essential for mediating regulation of RNA polymerase transcription. Required for proper pollen function. May stabilize the interaction of TFIID with selected promoters. Not redundant with TAF6B.

Belongs to the TAF6 family.

61.365 kDa

MSIVPKETVEVIAQSIGITNLLPEAALMLAPDVEYRVREIMQEAIKCMRHSKRTTLTASDVDGALNLRNVEPIYGFASGGPFRFRKAIGHRDLFYTDDREVDFKDVIEAPLPKAPLDTEIVCHWLAIEGVQPAIPENAPLEVIRAPAETKIHEQKDGPLIDVRLPVKHVLSRELQLYFQKIAELAMSKSNPPLYKEALVSLASDSGLHPLVPYFTNFIADEVSNGLNDFRLLFNLMHIVRSLLQNPHIHIEPYLHQLMPSVVTCLVSRKLGNRFADNHWELRDFAANLVSLICKRYGTVYITLQSRLTRTLVNALLDPKKALTQHYGAIQGLAALGHTVVRLLILSNLEPYLSLLEPELNAEKQKNQMKIYEAWRVYGALLRAAGLCIHGRLKIFPPLPSPSPSFLHKGKGKGKIISTDPHKRKLSVDSSENQSPQKRLITMDGPDGVHSQDQSGSAPMQVDNPVENDNPPQNSVQPSSSEQASDANESESRNGKVKESGRSRAITMKAILDQIWKDDLDSGRLLVKLHELYGDRILPFIPSTEMSVFL

TAF6

Transcription initiation factor TFIID subunit 6

516 amino acids

Functions as a component of the DNA-binding general transcription factor complex TFIID and the regulatory transcription regulatory histone acetylation (HAT) complexes SAGA, SALSA and SLIK. Binding of TFIID to a promoter (with or without TATA element) is the initial step in preinitiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription. SAGA is involved in RNA polymerase II-dependent transcriptional regulation of approximately 10% of yeast genes. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction (SPT3, SPT8 and SPT20) and promoter selectivity, interaction with transcription activators (GCN5, ADA2, ADA3 and TRA1), and chromatin modification through histone acetylation (GCN5) and deubiquitination (UBP8). SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac). SAGA interacts with DNA via upstream activating sequences (UASs). SALSA, an altered form of SAGA, may be involved in positive transcriptional regulation. SLIK is proposed to have partly overlapping functions with SAGA. It preferentially acetylates methylated histone H3, at least after activation at the GAL1-10 locus.

Belongs to the TAF6 family.

57.902 kDa

MSTQQQSYTIWSPQDTVKDVAESLGLENINDDVLKALAMDVEYRILEIIEQAVKFKRHSKRDVLTTDDVSKALRVLNVEPLYGYYDGSEVNKAVSFSKVNTSGGQSVYYLDEEEVDFDRLINEPLPQVPRLPTFTTHWLAVEGVQPAIIQNPNLNDIRVSQPPFIRGAIVTALNDNSLQTPVTSTTASASVTDTGASQHLSNVKPGQNTEVKPLVKHVLSKELQIYFNKVISTLTAKSQADEAAQHMKQAALTSLRTDSGLHQLVPYFIQFIAEQITQNLSDLQLLTTILEMIYSLLSNTSIFLDPYIHSLMPSILTLLLAKKLGGSPKDDSPQEIHEFLERTNALRDFAASLLDYVLKKFPQAYKSLKPRVTRTLLKTFLDINRVFGTYYGCLKGVSVLEGESIRFFLGNLNNWARLVFNESGITLDNIEEHLNDDSNPTRTKFTKEETQILVDTVISALLVLKKDLPDLYEGKGEKVTDEDKEKLLERCGVTIGFHILKRDDAKELISAIFFGE

taf6

Transcription initiation factor TFIID subunit 6

452 amino acids

TAFs are components of the transcription factor IID (TFIID) complex that are essential for mediating regulation of RNA polymerase transcription.

Belongs to the TAF6 family.

50.273 kDa

MSLTVWNIESIKDVAEMLGIGNLADEPAAAIAMDLEYRIHQVVQEATKFMVHSKRTVLTSADISSALRTLNVEPLYGFNNSRPLEFHEAAVGAGQNSLYYLDDEEVDFEKIINAPLPKVPRNISYSAHWLAIEGVQPAIPQNPTPSDHTVGEWASKGTSGVMPGASTAAKEARNGVTSMDNVEIKPLVRHVLSKELQLYFERITSALLDETNVELRDAALSSLRDDPGLHQLLPYFIMFLSDSVTRNLGNLVVLTTLMHMAWALLDNPNLFVEPYVQQLMPSILTCLVAKRLGSDPNNHEHYALRDLAAFLLGIVCDRFGNVYYTLKPRVTRTALKAFLDNTKPYSTHYGAIKGLKTMGKEAIRVLVVPNIKVYEVLVRKTLEKGNEEEIYEANKCMDALYDALLLLRDDQLPNQRTLPPNASGLLEKNVGSLMAEKIMKENDTSLLLGLLE