Su(var)3-9

Histone-lysine N-methyltransferase Su(var)3-9

635 amino acids

Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting Su(var)205/HP1 to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric regions. Involved in heterochromatic gene silencing including the modification of position-effect-variegation.

Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.

71.904 kDa

MATAEAQIGVNRNLQKQDLSNLDVSKLTPLSPEVISRQATINIGTIGHVAHGKSTVVKAISGVQTVRFKNELERNITIKLERLSEKKIKNLLTSKQQRQQYEIKQRSMLRHLAELRRHSRFRRLCTKPASSSMPASTSSVDRRTTRRSTSQTSLSPSNSSGYGSVFGCEEHDVDKIPSLNGFAKLKRRRSSCVGAPTPNSKRSKNNMGVIAKRPPKGEYVVERIECVEMDQYQPVFFVKWLGYHDSENTWESLANVADCAEMEKFVERHQQLYETYIAKITTELEKQLEALPLMENITVAEVDAYEPLNLQIDLILLAQYRAAGSRSQREPQKIGERALKSMQIKRAQFVRRKQLADLALFEKRMNHVEKPSPPIRVENNIDLDTIDSNFMYIHDNIIGKDVPKPEAGIVGCKCTEDTEECTASTKCCARFAGELFAYERSTRRLRLRPGSAIYECNSRCSCDSSCSNRLVQHGRQVPLVLFKTANGSGWGVRAATALRKGEFVCEYIGEIITSDEANERGKAYDDNGRTYLFDLDYNTAQDSEYTIDAANYGNISHFINHSCDPNLAVFPCWIEHLNVALPHLVFFTLRPIKAGEELSFDYIRADNEDVPYENLSTAVRVECRCGRDNCRKVLF

Su(var)3-9

Histone-lysine N-methyltransferase Su(var)3-9

633 amino acids

Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting Su(var)205/HP1 to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric regions. Involved in heterochromatic gene silencing including the modification of position-effect-variegation (By similarity).

Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.

71.612 kDa

MATAEAQVNVNRNLQKQDLRNLEVSNLTPLSPEVISRQATINIGTIGHVAHGKSTVVKAISGVQTVRFKNELERNITIKLERLSEKKIKLLLKSKHQRHKYDIQQQKLLRILAERRKARAMTPLAPASVLAPSMETARPRLRSTSLNSLSPSNSSGYGSILGCDDSDQSSQLVLKPNVLKRRRSNCVQIPTPAAKRSRKNDGTTVKRRPKGEYIVEKIESVEVVQFQPVFFVKWLGYDVSANTWESYVNLSDCAEMEKFVERHLQLHQHYIAQITGELDTQLSDIPQTEDLKTISIAEIDAYDPLELQIDFILLAQYRAAASRSQREPERIGARALHRMQVRRSHFARRKQLIDLLLFEHRMNRVELPSPPIRVENNWDLDTIDSGFKYIQKNIIGEGVPKPQAGLVGCMCRHQSGEQCTASSMCCGRMAGEIFAYDRTTGRLRLRPGSAIYECNSRCSCDESCTNRVVQNGRKHPLVLFKTSNGSGWGVRTPQPLKKGVFVCEYIGEIITCEEANERGKAYDDNGRTYLFDLDYNTSRDSEYTVDAANFGNISHFINHSCDPNLAVFPCWIEHLNTALPHLVFFTIRPIKAGEELSFDYIRADNEEVPYENLSTAARVQCRCGAANCRKVLF