Ssrp

FACT complex subunit Ssrp1

727 amino acids

Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. Binds specifically to single-stranded DNA and RNA with highest affinity for nucleotides G and U. The FACT complex is required for expression of Hox genes (By similarity).

Belongs to the SSRP1 family.

81.769 kDa

MTDSLEYNDINAEVRGVLSSGRLKLTDQNIIFKNNKTGKVEQISVDDIDLINSQKFVGTWGLRVFTKSGALHRFTGFRDSEHEKLGKFIKDAYSQEMVEKEMCVKGWNWGTARFMGSVLSFDKDSKTIFEVPLSHVSQCVTGKNEVTLEYHQNDDAPVGLLEMRFHIPAVESADDDPVEKFHQNVMSKASVISASGESIAIFREIQILTPRGRYDIKIFSTFFQLHGKTFDYKIPMDSVLRLFMLPHKDSRQMFFVLSLDPPIKQGQTRYHYLVLLFAPDEETTIELPFSEAELRDKYEGKLEKELSGPVYEVMGKVMKVLIGRKITGPGNFIGHSGTAAVGCSFKAAAGYLYPLERGFIYIHKPPLHIRFEEISSVNFARSGGSTRSFDFEVTLKNGTVHIFSSIEKEEYAKLFDFITQKKLHVSNMGKDKSGYKDVDFGDSDNENEPDAYLARLKAEAREKEEEDDDGDDSDEESTDEDFKPNENESDVAEEYDSNVEDDSDDDSDASGGGGDGGTDGSTKKKHKEKKNEKKEKTHKEKEKIKKPTKKKDTGKPKRGTSAFMLWLNDTRESIKRENPGIKVTEIAKKGGEMWKELKDKSKWEEAANKDKIRYQEEMRNYKSGAGGGSEDEKGGTSKATKKRKSEPSPSKKANTSGSGFKSKEYISDDESTSDDQEKVKEIPKKKNKSTAEDKDKNSKKSESEGGDSDDASNASEDDDEEEDEGSD

Ssrp

FACT complex subunit Ssrp1

723 amino acids

Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. Binds specifically to single-stranded DNA and RNA with highest affinity for nucleotides G and U. The FACT complex is required for expression of Hox genes.

Belongs to the SSRP1 family.

81.533 kDa

MTDSLEYNDINAEVRGVLCSGRLKMTEQNIIFKNTKTGKVEQISAEDIDLINSQKFVGTWGLRVFTKGGVLHRFTGFRDSEHEKLGKFIKAAYSQEMVEKEMCVKGWNWGTARFMGSVLSFDKESKTIFEVPLSHVSQCVTGKNEVTLEFHQNDDAPVGLLEMRFHIPAVESAEEDPVDKFHQNVMSKASVISASGESIAIFREIQILTPRGRYDIKIFSTFFQLHGKTFDYKIPMDSVLRLFMLPHKDSRQMFFVLSLDPPIKQGQTRYHYLVLLFAPDEETTIELPFSEAELRDKYEGKLEKEISGPVYEVMGKVMKVLIGRKITGPGNFIGHSGTAAVGCSFKAAAGYLYPLERGFIYIHKPPLHIRFEEISSVNFARSGGSTRSFDFEVTLKNGTVHIFSSIEKEEYAKLFDYITQKKLHVSNMGKDKSGYKDVDFGDSDNENEPDAYLARLKAEAREKEEDDDDGDSDEESTDEDFKPNENESDVAEEYDSNVESDSDDDSDASGGGGDSDGAKKKKEKKSEKKEKKEKKHKEKERTKKPSKKKKDSGKPKRATTAFMLWLNDTRESIKRENPGIKVTEIAKKGGEMWKELKDKSKWEDAAAKDKQRYHDEMRNYKPEAGGDSDNEKGGKSSKKRKTEPSPSKKANTSGSGFKSKEYISDDDSTSSDDEKDNEPAKKKSKPPSDGDAKKKKAKSESEPEESEEDSNASDEDEEDEASD