Protein
Serine protease inhibitor 88Ea
Organism
Drosophila melanogaster
Function
Serine protease inhibitor with activity toward trypsin (PubMed:18956323). Negatively regulates the Toll signaling pathway and suppresses the expression of the antifungal peptide drosomycin (PubMed:19581577). Its negative regulation of the Toll signaling pathway also results in the inhibition of the melanization immune response via the phenoloxidase (PPO1) cascade (PubMed:19581577). Essential for unfolding and expansion of the wings after emergence from the pupal case (PubMed:18956323). May regulate the Toll pathway by blocking the proteolysis of the Toll ligand spz (PubMed:19581577).
Similarity
Belongs to the serpin family.
Sequence
MHILSISLMAVLPAIALAGLCGVEPDAGLLDQRLNLYKGQQNFAVSMLNVIRQSTPNENVFFSPYSTYHALLLAYFGSSGDTEKELAKVLHLDWADSKEVVRSAYILEKMNRKERQSKMPLEFSSADRIFFANDLHVTECARNRLAEEVQQIDFKSQTEESRKQINDWIAKQTHDQIRNMLSADEITPRTRLVLANAAYLKGQWLSQFKTEKTVPMPFYTSPSNYSLVSMMQQKGTFLLNVDEQLRAHVLQLPYRTVFESQEKEDSSPDENSDISMVLILPPFNSNSLEDVLSRLNADSLDDSLKQAMPREIEVSLPKFEFEQRLELNPILAKMGVSKMFDESVATFDDLTSETISIGDSKHVAKIKVDEEGSTAAAATVLFTYRSARPVEPAKFECNHPFLFVIYDRTSRSILFTGIYRDPKTIKQ