sin1

Target of rapamycin complex 2 subunit sin1

665 amino acids

Component of TORC2, which regulates multiple cellular processes to control cell growth in response to environmental signals. TORC2 is required for cell survival under various stress conditions. TORC2 positively controls G1 cell-cycle arrest, sexual development and amino acid uptake. Positively regulates amino acid uptake through the control of expression of amino acid permeases.

Belongs to the SIN1 family.

74.079 kDa

MELTREKVLLLTFLRMQYSHILPDSIENRVISTEAPEWELDKSLQDLLIHDYDYSKTSFSSSPPIVANDTVSNVRKPSDTKQVNGAGGQVNHSRAEDSDYATSDLSESSDVGDDDNSCIFSFSKVPMQKDVASIKEEERLDPKISTLNNIDAIANLKLTNMVESSQAVNLTSSKQSSINQQSSVSTDYDDLRSISEESFHLSQGEIPLTFPMNSSLTDTEADAVVAVDALFPGKQRGTHNTVNKARSVSNAKAPTSALRALLEHKENSSQNGPLAENFATFSGHAESNALRLNIYFPSSESPSKPLFVELRKNVLVSEAIGYILLQYVNQQLVPPIEDEAQNPNYWNLRIVEDDGELDEDFPALDRVGPLSKFGFDAFALVKATPAQIKENQAAYPFKSKHPTSIPEANNKTHIRHTSSTSSQSQKQAQDVKDTLNTSHVVQVRLPPYGDNARFCNIEISKTTRLAMVLNQVCWMKQLERFKYTLRVAGSDTVLPLDKTFSSLDGNPTLELVKKKVRDKKGSTQQLPTSSPQNSVYGSIKKDAQSSTYNATDIMSSNTYQEFLVWKRQPVSFMGRHERLLAIDGEYVHIMPSESKNIFETPKTSSIHAGSIILCKQSKKSPCNFKMIVSKNRETKRYDFEVLSALEAAIIVSRIRALMNTVKKIN

Sin1

Stress-activated map kinase-interacting protein 1

578 amino acids

Component of a multiprotein complex that phosphorylates Akt1, a protein that regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes.

Belongs to the SIN1 family.

65.402 kDa

MATYSNQHWLLSHIRNSFISTDDTGMCETVMLSDDMPKHYLRKFNSSAGVESHRRRPLKPPLASALPDRNTRHPDAPMQEVDFMCYPGLDLSDDEEDMSTHSFDIQMYPEVGAHRFRSNTAQKLEKLDIAKRRAARIKSINYNEEVQPPEDKDFFMRKEIPNIKPTIPKEKKANDDELSDEGVQSMLTEQLAKSPKQTQNKFIEFARFDGTSQVGMQTKRINVYLNMLPEPDRNYPLKVCVLSTAKIQEVIGFVCYKTSLQYPDVPLKSLQHYGLYMTEDNDDMEDFPPLDNREPCSKFGFSHLTLAERRPLAPVTRVDYPGQLGNKSMTSEDDKATLADAALRALKNITLNGGAADPGGGAVGGGEGDGDGDDSPHDNVKEYEKRLLNHNDMLEAPMHRSFRLNIIDKRFFKSDVTLGISGERIEIDQYKNAKFWPQKKPVSTPIDLVAHCEIVERRHLKALLRIWLKSNSSSSSLPSGCTSAPINASVTTLNTGTGSSSAGIAHSPSSPGNSFGFFMTSNIRFKHYDFDTDTHTAEQINSKLNCILEMRSSELRREFLQQRERKQERQQVKKQLKL

Sin1

Stress-activated map kinase-interacting protein 1

569 amino acids

Component of a multiprotein complex that phosphorylates Akt1, a protein that regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes.

Belongs to the SIN1 family.

64.239 kDa

MATYSNQHWLLSHIRNSFISTDDTGMCETVMLSDDMPKHYLRKFGNSGAGGDHYHWRRAHKTPPTGGGTTPERNTRHPDAPLQEVDFICYPGLDLSDDEEDMSTHSFDIQMYPEVGAHRFRSNTAQKLEKLDIAKRRAARIKSVNYQEEVQPPESDDFFKRKELPLSKAERVKNEPKANDDDLSDEGVQSQLTEQLAKSPKQAQNRFIEFARFDGTSQVGMQTKRINVFLNMLPEPDRNYPLKICVVATAKIQEVIGFVCYRTSLQYPDVPLKSLQHYALYMTEDNDDMEDFPPLDNREPCSKFGFSQLTLAERRPLAPVTRVDYHSQLGSKSMTSVEDKTALSDAAVKALQNISLNGGTSDPGGGGGGGDSPHDNVKEYEKRLLNHNDMLEAPMHRTFRLNIIDKRFFKSDVTLGISGERIEIDQCKNAKFWPQKKPVSTPIDFVAHCEILERRHLKALLRIWLKSNSSSPSFSTGCTSAPINASVTTLNAGSGSGGIAHSPSSPGHSSGLFSSSNIRFKHYDFDTDTHTAEQIHNKLNCILEMRSSDLRREFLLQRDRKQEKRQLKL